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Article: Endocrine characteristics, body mass index and metabolic syndrome in women with polycystic ovary syndrome

TitleEndocrine characteristics, body mass index and metabolic syndrome in women with polycystic ovary syndrome
Authors
KeywordsBody mass index
Metabolic syndrome
Polycystic ovary syndrome
Issue Date2019
PublisherElsevier Ltd. The Journal's web site is located at http://www.rbmojournal.com
Citation
Reproductive BioMedicine Online, 2019, v. 39 n. 5, p. 868-876 How to Cite?
AbstractResearch question: The study aimed to evaluate the associations of endocrine and ultrasound characteristics with metabolic syndrome in women with polycystic ovary syndrome (PCOS), and whether these associations were modified by body mass index (BMI). Design: The study was a secondary analysis of baseline data from a randomized controlled trial of induction of ovulation in women with PCOS. Results: Among 947 Chinese women with PCOS, 153 (16.2%) were diagnosed with metabolic syndrome. The prevalence of metabolic syndrome in women with normal (<24 kg/m 2) and high (≥24 kg/m 2) BMI was 3.6% and 30.5%, respectively. In all women, a high free androgen index (FAI ≥5%) was positively associated with metabolic syndrome (adjusted odds ratio [OR] 2.06, 95% confidence interval [CI] 1.11–3.82). High FAI was positively associated with metabolic syndrome among women with high BMI (adjusted OR 3.37, 95% CI 1.78–6.37), but the association was not significant in women with normal BMI (adjusted OR 1.27, 95% CI 0.34–4.70). The presence of polycystic ovary morphology was negatively associated with metabolic syndrome (adjusted OR 0.52, 95% CI 0.26–1.03) in all women (normal BMI adjusted OR 0.42, 95% CI 0.11–1.67; high BMI adjusted OR 0.54, 95% CI 0.23–1.28). LH, sex hormone-binding globulin (SHBG) and anti-Müllerian hormone (AMH) were negatively associated with metabolic syndrome. The associations of FAI, SHBG and AMH in relation to metabolic syndrome were significantly modified by BMI. Conclusion(s): The associations of endocrine characteristic with metabolic syndrome were modified by BMI in women with PCOS. Women with PCOS and normal BMI did not have an increased risk of metabolic syndrome.
Persistent Identifierhttp://hdl.handle.net/10722/287755
ISSN
2023 Impact Factor: 3.7
2023 SCImago Journal Rankings: 1.214
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, J-
dc.contributor.authorWu, Q-
dc.contributor.authorWang, CC-
dc.contributor.authorWang, R-
dc.contributor.authorNg, EHY-
dc.contributor.authorLiu, JP-
dc.contributor.authorMol, BWJ-
dc.contributor.authorWu, XK-
dc.contributor.authorLi, WT-
dc.contributor.authorPCOSAct Study Group-
dc.date.accessioned2020-10-05T12:02:48Z-
dc.date.available2020-10-05T12:02:48Z-
dc.date.issued2019-
dc.identifier.citationReproductive BioMedicine Online, 2019, v. 39 n. 5, p. 868-876-
dc.identifier.issn1472-6483-
dc.identifier.urihttp://hdl.handle.net/10722/287755-
dc.description.abstractResearch question: The study aimed to evaluate the associations of endocrine and ultrasound characteristics with metabolic syndrome in women with polycystic ovary syndrome (PCOS), and whether these associations were modified by body mass index (BMI). Design: The study was a secondary analysis of baseline data from a randomized controlled trial of induction of ovulation in women with PCOS. Results: Among 947 Chinese women with PCOS, 153 (16.2%) were diagnosed with metabolic syndrome. The prevalence of metabolic syndrome in women with normal (<24 kg/m 2) and high (≥24 kg/m 2) BMI was 3.6% and 30.5%, respectively. In all women, a high free androgen index (FAI ≥5%) was positively associated with metabolic syndrome (adjusted odds ratio [OR] 2.06, 95% confidence interval [CI] 1.11–3.82). High FAI was positively associated with metabolic syndrome among women with high BMI (adjusted OR 3.37, 95% CI 1.78–6.37), but the association was not significant in women with normal BMI (adjusted OR 1.27, 95% CI 0.34–4.70). The presence of polycystic ovary morphology was negatively associated with metabolic syndrome (adjusted OR 0.52, 95% CI 0.26–1.03) in all women (normal BMI adjusted OR 0.42, 95% CI 0.11–1.67; high BMI adjusted OR 0.54, 95% CI 0.23–1.28). LH, sex hormone-binding globulin (SHBG) and anti-Müllerian hormone (AMH) were negatively associated with metabolic syndrome. The associations of FAI, SHBG and AMH in relation to metabolic syndrome were significantly modified by BMI. Conclusion(s): The associations of endocrine characteristic with metabolic syndrome were modified by BMI in women with PCOS. Women with PCOS and normal BMI did not have an increased risk of metabolic syndrome.-
dc.languageeng-
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.rbmojournal.com-
dc.relation.ispartofReproductive BioMedicine Online-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License-
dc.subjectBody mass index-
dc.subjectMetabolic syndrome-
dc.subjectPolycystic ovary syndrome-
dc.titleEndocrine characteristics, body mass index and metabolic syndrome in women with polycystic ovary syndrome-
dc.typeArticle-
dc.identifier.emailNg, EHY: nghye@hku.hk-
dc.identifier.authorityNg, EHY=rp00426-
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.rbmo.2019.06.014-
dc.identifier.pmid31444050-
dc.identifier.scopuseid_2-s2.0-85070881267-
dc.identifier.hkuros314952-
dc.identifier.volume39-
dc.identifier.issue5-
dc.identifier.spage868-
dc.identifier.epage876-
dc.identifier.isiWOS:000496224700019-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1472-6483-

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