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Article: Development of magnet-driven and image-guided degradable microrobots for the precise delivery of engineered stem cells for cancer therapy

TitleDevelopment of magnet-driven and image-guided degradable microrobots for the precise delivery of engineered stem cells for cancer therapy
Authors
Keywordscell delivery
in vivo applications
magnet‐driven
microrobots
photoacoustic imaging
Issue Date2020
PublisherWiley - VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jabout/107640323/2421_info.html
Citation
Small, 2020, v. 16 n. 41, p. article no. e1906908 How to Cite?
AbstractPrecise delivery of therapeutic cells to the desired site in vivo is an emerging and promising cellular therapy in precision medicine. This paper presents the development of a magnet‐driven and image‐guided degradable microrobot that can precisely deliver engineered stem cells for orthotopic liver tumor treatment. The microrobot employs a burr‐like porous sphere structure and is made with a synthesized composite to fulfill degradability, mechanical strength, and magnetic actuation capability simultaneously. The cells can be spontaneously released from the microrobots on the basis of the optimized microrobot structure. The microrobot is actuated by a gradient magnetic field and guided by a unique photoacoustic imaging technology. In preclinical experiments on nude mice, microrobots carrying cells are injected via the portal vein and the released cells from the microrobots can inhibit the tumor growth greatly. This paper reveals for the first time of using degradable microrobots for precise delivery of therapeutic cells in vascular tissue and demonstrates its therapeutic effect in preclinical test.
Persistent Identifierhttp://hdl.handle.net/10722/287730
ISSN
2023 Impact Factor: 13.0
2023 SCImago Journal Rankings: 3.348
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWei, T-
dc.contributor.authorLiu, J-
dc.contributor.authorLi, D-
dc.contributor.authorChen, S-
dc.contributor.authorZhang, Y-
dc.contributor.authorLi, J-
dc.contributor.authorFan, L-
dc.contributor.authorGuan, Z-
dc.contributor.authorLo, CM-
dc.contributor.authorWang, L-
dc.contributor.authorMan, K-
dc.contributor.authorSun, D-
dc.date.accessioned2020-10-05T12:02:25Z-
dc.date.available2020-10-05T12:02:25Z-
dc.date.issued2020-
dc.identifier.citationSmall, 2020, v. 16 n. 41, p. article no. e1906908-
dc.identifier.issn1613-6810-
dc.identifier.urihttp://hdl.handle.net/10722/287730-
dc.description.abstractPrecise delivery of therapeutic cells to the desired site in vivo is an emerging and promising cellular therapy in precision medicine. This paper presents the development of a magnet‐driven and image‐guided degradable microrobot that can precisely deliver engineered stem cells for orthotopic liver tumor treatment. The microrobot employs a burr‐like porous sphere structure and is made with a synthesized composite to fulfill degradability, mechanical strength, and magnetic actuation capability simultaneously. The cells can be spontaneously released from the microrobots on the basis of the optimized microrobot structure. The microrobot is actuated by a gradient magnetic field and guided by a unique photoacoustic imaging technology. In preclinical experiments on nude mice, microrobots carrying cells are injected via the portal vein and the released cells from the microrobots can inhibit the tumor growth greatly. This paper reveals for the first time of using degradable microrobots for precise delivery of therapeutic cells in vascular tissue and demonstrates its therapeutic effect in preclinical test.-
dc.languageeng-
dc.publisherWiley - VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jabout/107640323/2421_info.html-
dc.relation.ispartofSmall-
dc.rightsThis is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectcell delivery-
dc.subjectin vivo applications-
dc.subjectmagnet‐driven-
dc.subjectmicrorobots-
dc.subjectphotoacoustic imaging-
dc.titleDevelopment of magnet-driven and image-guided degradable microrobots for the precise delivery of engineered stem cells for cancer therapy-
dc.typeArticle-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.emailMan, K: kwanman@hku.hk-
dc.identifier.authorityLo, CM=rp00412-
dc.identifier.authorityMan, K=rp00417-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/smll.201906908-
dc.identifier.pmid32954642-
dc.identifier.scopuseid_2-s2.0-85091184122-
dc.identifier.hkuros315040-
dc.identifier.volume16-
dc.identifier.issue41-
dc.identifier.spagearticle no. e1906908-
dc.identifier.epagearticle no. e1906908-
dc.identifier.eissn1613-6829-
dc.identifier.isiWOS:000571117400001-
dc.publisher.placeGermany-
dc.identifier.issnl1613-6810-

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