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Article: Impact of thoracic cage dimension and geometry on cardiopulmonary function in patients with congenital scoliosis: a prospective study

TitleImpact of thoracic cage dimension and geometry on cardiopulmonary function in patients with congenital scoliosis: a prospective study
Authors
Keywordsexercise test
exercise tolerance
pulmonary ventilation
scoliosis
spirometry
Issue Date2019
PublisherLippincott, Williams & Wilkins. The Journal's web site is located at http://journals.lww.com/spinejournal/pages/default.aspx
Citation
Spine, 2019, v. 44 n. 20, p. 1441-1448 How to Cite?
AbstractStudy Design. A prospective study of cardiopulmonary function in patients with congenital scoliosis (CS). Objective. To investigate the relationship of thoracic cage deformity and exercise tolerance in CS patients. Summary of Background Data. Congenital thoracic scoliosis and chest deformity lead to restrictive pulmonary dysfunction and in some severe cases cause cardiopulmonary failure. However, it is still unknown the relationship between thoracic deformity and exercise performance. Methods. Patients with congenital thoracic spinal deformity were included and had radiological assessment of thoracic cage, pulmonary function testing, and cardiopulmonary exercise testing. Thoracic dimension including height, width, and depth were measured and geometry parameters were calculated. Two-tailed Pearson and Spearman correlation test and linear regression analysis were performed to investigate correlation of radiographic parameters, pulmonary function, and physical capacity. Results. Sixty patients (41 females and 19 males) were included, with an average age of 18.9 years. Patients with smaller thoracic height (P < 0.001) and width (P < 0.01) and larger depth (P < 0.05) had significantly worse static pulmonary function. In exercise testing, these patients showed significant tendency of ventilation insufficiency, including lower minute ventilation (P < 0.05), faster breathing frequency (P < 0.05), and smaller tidal volume (P < 0.01). Thoracic depth was negatively correlated to exercise capacity, reflected by work rate (P < 0.001), peak oxygen intake (P < 0.001), and heart rate (P = 0.043). Patients with abnormal thoracic geometry, especially a lower ratio of height to depth and a lower ratio of width to depth, have significantly worse static pulmonary function and exercise capacity (all P < 0.05). Conclusion. Decreasing thoracic height and width results in restrictive pulmonary dysfunction. Distortion and asymmetry of the thoracic cage are associated with abnormal breathing pattern and reduction of exercise capacity. Level of Evidence: 3
Persistent Identifierhttp://hdl.handle.net/10722/287689
ISSN
2023 Impact Factor: 2.6
2023 SCImago Journal Rankings: 1.221
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLIN, Y-
dc.contributor.authorTAN, H-
dc.contributor.authorRONG, T-
dc.contributor.authorCHEN, C-
dc.contributor.authorSHEN, J-
dc.contributor.authorLIU, S-
dc.contributor.authorYUAN, W-
dc.contributor.authorCONG, H-
dc.contributor.authorCHEN, L-
dc.contributor.authorLUO, J-
dc.contributor.authorKwan, KYH-
dc.date.accessioned2020-10-05T12:01:48Z-
dc.date.available2020-10-05T12:01:48Z-
dc.date.issued2019-
dc.identifier.citationSpine, 2019, v. 44 n. 20, p. 1441-1448-
dc.identifier.issn0362-2436-
dc.identifier.urihttp://hdl.handle.net/10722/287689-
dc.description.abstractStudy Design. A prospective study of cardiopulmonary function in patients with congenital scoliosis (CS). Objective. To investigate the relationship of thoracic cage deformity and exercise tolerance in CS patients. Summary of Background Data. Congenital thoracic scoliosis and chest deformity lead to restrictive pulmonary dysfunction and in some severe cases cause cardiopulmonary failure. However, it is still unknown the relationship between thoracic deformity and exercise performance. Methods. Patients with congenital thoracic spinal deformity were included and had radiological assessment of thoracic cage, pulmonary function testing, and cardiopulmonary exercise testing. Thoracic dimension including height, width, and depth were measured and geometry parameters were calculated. Two-tailed Pearson and Spearman correlation test and linear regression analysis were performed to investigate correlation of radiographic parameters, pulmonary function, and physical capacity. Results. Sixty patients (41 females and 19 males) were included, with an average age of 18.9 years. Patients with smaller thoracic height (P < 0.001) and width (P < 0.01) and larger depth (P < 0.05) had significantly worse static pulmonary function. In exercise testing, these patients showed significant tendency of ventilation insufficiency, including lower minute ventilation (P < 0.05), faster breathing frequency (P < 0.05), and smaller tidal volume (P < 0.01). Thoracic depth was negatively correlated to exercise capacity, reflected by work rate (P < 0.001), peak oxygen intake (P < 0.001), and heart rate (P = 0.043). Patients with abnormal thoracic geometry, especially a lower ratio of height to depth and a lower ratio of width to depth, have significantly worse static pulmonary function and exercise capacity (all P < 0.05). Conclusion. Decreasing thoracic height and width results in restrictive pulmonary dysfunction. Distortion and asymmetry of the thoracic cage are associated with abnormal breathing pattern and reduction of exercise capacity. Level of Evidence: 3-
dc.languageeng-
dc.publisherLippincott, Williams & Wilkins. The Journal's web site is located at http://journals.lww.com/spinejournal/pages/default.aspx-
dc.relation.ispartofSpine-
dc.rightsThis is a non-final version of an article published in final form in (provide complete journal citation)-
dc.subjectexercise test-
dc.subjectexercise tolerance-
dc.subjectpulmonary ventilation-
dc.subjectscoliosis-
dc.subjectspirometry-
dc.titleImpact of thoracic cage dimension and geometry on cardiopulmonary function in patients with congenital scoliosis: a prospective study-
dc.typeArticle-
dc.identifier.emailKwan, KYH: kyhkwan@hku.hk-
dc.identifier.authorityKwan, KYH=rp02014-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/BRS.0000000000003178-
dc.identifier.pmid31365514-
dc.identifier.scopuseid_2-s2.0-85072849142-
dc.identifier.hkuros315339-
dc.identifier.volume44-
dc.identifier.issue20-
dc.identifier.spage1441-
dc.identifier.epage1448-
dc.identifier.isiWOS:000507923100014-
dc.publisher.placeUnited States-
dc.identifier.issnl0362-2436-

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