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Conference Paper: Scaffold-based and Scaffold-free Strategies in Dental Pulp Regeneration
Title | Scaffold-based and Scaffold-free Strategies in Dental Pulp Regeneration |
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Authors | |
Keywords | Biomaterials cell spheroids dental pulp regeneration scaffolds scaffold free |
Issue Date | 2020 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.jendodon.com |
Citation | Pulp Biology and Regeneration Group Satellite Meeting: Bridging Basic and Translational Research in Pulp Biology – Developing Technologies for Regenerating Vital Dental Tissues, Portland, OR, 23-25 June 2019. In Journal of Endodontics, 2020, v. 46 n. 9, suppl., p. S81-S89 How to Cite? |
Abstract | Regenerative dentistry has come a long way from pulp capping to pulp regeneration research, which aims to regenerate the pulp-dentin complex and restore its functions compromised by pulp injury and/or inflammation. Because of unique anatomic limitations of the tooth structure, engineering a suitable microenvironment that facilitates angio/vasculogenesis and innervation is a challenging task. Cell-based tissue engineering approaches have shown great potential in achieving this goal. Biomedical approaches in creating a regenerative microenvironment are mainly represented by either scaffold-based or scaffold-free strategies. The scaffold-based strategy mainly relies on the use of biomaterials to create a structural base that supports cells throughout the process of tissue formation. The scaffold could be a classic 3-dimensional construct with interconnected pores, a hydrogel with cells embedded in it, or a combination of these 2. The scaffold-free approach has been considered a bottom-up strategy that uses cell sheets, spheroids, or tissue strands as building blocks. The outcome of this strategy relies on the capacity of these building blocks to secrete a favorable extracellular matrix and to fuse into larger tissue constructs. Both the scaffold-free and scaffold-based systems are required as complementary, rather than competing, approaches for pulp regeneration. A combined synergetic strategy, through which multicellular building blocks could be integrated with robust 3-dimensional scaffolds, might represent an optimal solution to circumvent some of the major drawbacks of the current methods in pulp regeneration while concurrently fostering their advantages. |
Persistent Identifier | http://hdl.handle.net/10722/287611 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 1.356 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Dissanayaka, WL | - |
dc.contributor.author | Zhang, C | - |
dc.date.accessioned | 2020-10-05T12:00:37Z | - |
dc.date.available | 2020-10-05T12:00:37Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Pulp Biology and Regeneration Group Satellite Meeting: Bridging Basic and Translational Research in Pulp Biology – Developing Technologies for Regenerating Vital Dental Tissues, Portland, OR, 23-25 June 2019. In Journal of Endodontics, 2020, v. 46 n. 9, suppl., p. S81-S89 | - |
dc.identifier.issn | 0099-2399 | - |
dc.identifier.uri | http://hdl.handle.net/10722/287611 | - |
dc.description.abstract | Regenerative dentistry has come a long way from pulp capping to pulp regeneration research, which aims to regenerate the pulp-dentin complex and restore its functions compromised by pulp injury and/or inflammation. Because of unique anatomic limitations of the tooth structure, engineering a suitable microenvironment that facilitates angio/vasculogenesis and innervation is a challenging task. Cell-based tissue engineering approaches have shown great potential in achieving this goal. Biomedical approaches in creating a regenerative microenvironment are mainly represented by either scaffold-based or scaffold-free strategies. The scaffold-based strategy mainly relies on the use of biomaterials to create a structural base that supports cells throughout the process of tissue formation. The scaffold could be a classic 3-dimensional construct with interconnected pores, a hydrogel with cells embedded in it, or a combination of these 2. The scaffold-free approach has been considered a bottom-up strategy that uses cell sheets, spheroids, or tissue strands as building blocks. The outcome of this strategy relies on the capacity of these building blocks to secrete a favorable extracellular matrix and to fuse into larger tissue constructs. Both the scaffold-free and scaffold-based systems are required as complementary, rather than competing, approaches for pulp regeneration. A combined synergetic strategy, through which multicellular building blocks could be integrated with robust 3-dimensional scaffolds, might represent an optimal solution to circumvent some of the major drawbacks of the current methods in pulp regeneration while concurrently fostering their advantages. | - |
dc.language | eng | - |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.jendodon.com | - |
dc.relation.ispartof | Journal of Endodontics | - |
dc.relation.ispartof | Pulp Biology and Regeneration Group Satellite Meeting | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Biomaterials | - |
dc.subject | cell spheroids | - |
dc.subject | dental pulp regeneration | - |
dc.subject | scaffolds | - |
dc.subject | scaffold free | - |
dc.title | Scaffold-based and Scaffold-free Strategies in Dental Pulp Regeneration | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Dissanayaka, WL: warunad@hku.hk | - |
dc.identifier.email | Zhang, C: zhangcf@hku.hk | - |
dc.identifier.authority | Dissanayaka, WL=rp02216 | - |
dc.identifier.authority | Zhang, C=rp01408 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1016/j.joen.2020.06.022 | - |
dc.identifier.pmid | 32950199 | - |
dc.identifier.scopus | eid_2-s2.0-85090965109 | - |
dc.identifier.hkuros | 314941 | - |
dc.identifier.volume | 46 | - |
dc.identifier.issue | 9, suppl. | - |
dc.identifier.spage | S81 | - |
dc.identifier.epage | S89 | - |
dc.identifier.isi | WOS:000573413200012 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0099-2399 | - |