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Conference Paper: Comparing Surgery Alone or Surgery plus Radiation Therapy in Craniopharyngioma Management

TitleComparing Surgery Alone or Surgery plus Radiation Therapy in Craniopharyngioma Management
Authors
Keywordssepsis
radiation therapy
craniopharyngioma
disease progression
fatal outcome
Issue Date2018
PublisherOxford University Press. The Journal's web site is located at http://neuro-oncology.dukejournals.org
Citation
The 18th International Symposium on Pediatric Neuro-Oncology (ISPNO 2018), Denver, Colorado, USA, 30 June – 3 July 2018. Abstracts in Neuro-Oncology, 2018, v. 20 n. Suppl. 2, p. i42, article no. CRAN-26 How to Cite?
AbstractBACKGROUND: The management approach for craniopharyngioma has not reach a consensus between neurosurgeons and radiation oncologists for the past decades. We reviewed our experience and assessed the outcome of these 2 approaches. METHOD: This is a retrospective review and children with oncological conditions were admitted to 5 public hospitals. Their data were collected prospectively by 2 full time data managers. Patients’ progress was updated annually and the data were crossed checked by the principle investigators. Survival data was analyzed by the Kaplan-Meier Analysis. RESULT: From Jan 1994 to Dec 2016 (13-yrs), 21 children (<18yrs) with craniopharyngioma was identified. The estimated incidence was 1.47/million children<15yrs/yr. M:F=10:9 and median age was 9.7yrs (range 2mons to 16.5yrs). 12/21 (57%) children were treated with surgery alone as primary approach. Even statistically insignificant, the 6yrs relapse-free-survival was 80% vs 50.3% between surgery+radiation therapy (RT) vs surgery alone. 8/13(61.5%) children in one hospital (HospA) were treated with surgery+RT as primary approach if there was residual lesion post-operatively, but other hospitals (Others) mainly adopted surgery alone as primary approach. The relapsed rate was only 1/13 (7.7%) from HospA. However, 6/8 (75%) patients in Others relapsed and 3 patients eventually died (2 disease progression; 1 sepsis). The overall incidence of hypopituitarism was lower in the HospA (72% vs 87.5%). No other radiation induced complication was noted. CONCLUSION: If with residue, surgery alone approach for craniopharyngioma is associated with a high risk of relapse. Despite being a benign tumor, patients with multiple relapses can have fatal outcome.
Persistent Identifierhttp://hdl.handle.net/10722/287601
ISSN
2019 Impact Factor: 10.247
2015 SCImago Journal Rankings: 3.196

 

DC FieldValueLanguage
dc.contributor.authorChan, GCF-
dc.contributor.authorKu, DTL-
dc.contributor.authorLuk, CW-
dc.contributor.authorLing, ASC-
dc.contributor.authorShing, MMK-
dc.contributor.authorLiu, APY-
dc.date.accessioned2020-10-05T12:00:28Z-
dc.date.available2020-10-05T12:00:28Z-
dc.date.issued2018-
dc.identifier.citationThe 18th International Symposium on Pediatric Neuro-Oncology (ISPNO 2018), Denver, Colorado, USA, 30 June – 3 July 2018. Abstracts in Neuro-Oncology, 2018, v. 20 n. Suppl. 2, p. i42, article no. CRAN-26-
dc.identifier.issn1522-8517-
dc.identifier.urihttp://hdl.handle.net/10722/287601-
dc.description.abstractBACKGROUND: The management approach for craniopharyngioma has not reach a consensus between neurosurgeons and radiation oncologists for the past decades. We reviewed our experience and assessed the outcome of these 2 approaches. METHOD: This is a retrospective review and children with oncological conditions were admitted to 5 public hospitals. Their data were collected prospectively by 2 full time data managers. Patients’ progress was updated annually and the data were crossed checked by the principle investigators. Survival data was analyzed by the Kaplan-Meier Analysis. RESULT: From Jan 1994 to Dec 2016 (13-yrs), 21 children (<18yrs) with craniopharyngioma was identified. The estimated incidence was 1.47/million children<15yrs/yr. M:F=10:9 and median age was 9.7yrs (range 2mons to 16.5yrs). 12/21 (57%) children were treated with surgery alone as primary approach. Even statistically insignificant, the 6yrs relapse-free-survival was 80% vs 50.3% between surgery+radiation therapy (RT) vs surgery alone. 8/13(61.5%) children in one hospital (HospA) were treated with surgery+RT as primary approach if there was residual lesion post-operatively, but other hospitals (Others) mainly adopted surgery alone as primary approach. The relapsed rate was only 1/13 (7.7%) from HospA. However, 6/8 (75%) patients in Others relapsed and 3 patients eventually died (2 disease progression; 1 sepsis). The overall incidence of hypopituitarism was lower in the HospA (72% vs 87.5%). No other radiation induced complication was noted. CONCLUSION: If with residue, surgery alone approach for craniopharyngioma is associated with a high risk of relapse. Despite being a benign tumor, patients with multiple relapses can have fatal outcome.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://neuro-oncology.dukejournals.org-
dc.relation.ispartofNeuro-Oncology-
dc.relation.ispartofThe 18th International Symposium on Pediatric Neuro-Oncology (ISPNO 2018)-
dc.subjectsepsis-
dc.subjectradiation therapy-
dc.subjectcraniopharyngioma-
dc.subjectdisease progression-
dc.subjectfatal outcome-
dc.titleComparing Surgery Alone or Surgery plus Radiation Therapy in Craniopharyngioma Management-
dc.typeConference_Paper-
dc.identifier.emailChan, GCF: gcfchan@hku.hk-
dc.identifier.emailLiu, APY: apyliu@hku.hk-
dc.identifier.authorityChan, GCF=rp00431-
dc.identifier.authorityLiu, APY=rp01357-
dc.description.natureabstract-
dc.identifier.doi10.1093/neuonc/noy059.062-
dc.identifier.hkuros315020-
dc.identifier.volume20-
dc.identifier.issueSuppl. 2-
dc.identifier.spagei42-
dc.identifier.epagei42-
dc.publisher.placeUnited States-

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