File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Characteristics and Management of Patients with Venous Thromboembolism: The GARFIELD-VTE Registry

TitleCharacteristics and Management of Patients with Venous Thromboembolism: The GARFIELD-VTE Registry
Authors
Keywordsvenous thromboembolism
registry
deep vein thrombosis
pulmonary embolism
anticoagulation
Issue Date2019
PublisherSchattauer GmbH. The Journal's web site is located at http://www.thrombosis-online.com
Citation
Thrombosis and Haemostasis, 2019, v. 119 n. 2, p. 319-327 How to Cite?
AbstractBackground Management of venous thromboembolism (VTE), encompassing both deep vein thrombosis (DVT) and pulmonary embolism (PE), varies worldwide. Methods The Global Anticoagulant Registry in the FIELD – Venous Thromboembolism (GARFIELD-VTE) is a prospective, observational study of 10,685 patients with objectively diagnosed VTE recruited from May 2014 to January 2017 at 417 sites in 28 countries. All patients are followed for at least 3 years. We describe the baseline characteristics of the study population and their management within 30 days of diagnosis. Results The median age was 60.2 years; 50.4% were male; 61.7% had DVT and 38.3% had PE ± DVT; and 32.3% were obese (body mass index ≥ 30 kg/m2). The most common risk factors were surgery (12.5%), hospitalization (12.0%) and trauma to the lower limbs (7.8%). At the time of VTE diagnosis, 10.1% had active cancer and 5.7% were chronically immobilized. Treatment for VTE was anticoagulant (AC) therapy alone in 90.9% of patients; 5.1% received thrombolytic and/or surgical/mechanical therapy ± AC and 4.0% received no therapy. Pre-diagnosis, 12.8% received AC therapy alone and 0.2% received thrombolytic and/or surgical/mechanical therapy ± AC. After diagnosis, parenteral AC therapy alone was administered in 17.6% of patients, and it was followed by a direct oral AC (DOAC) in 16.4% or a vitamin K antagonist (VKA) in 26.8%. DOACs alone were prescribed to 32.3% of patients, while 5.9% received VKA alone. Conclusion The initial findings from this global registry highlight the heterogeneity in characteristics and management of VTE patients. Prospective follow-up will reveal the impact of this heterogeneity on outcomes.
Persistent Identifierhttp://hdl.handle.net/10722/287377
ISSN
2023 Impact Factor: 5.0
2023 SCImago Journal Rankings: 1.248
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAgeno, W-
dc.contributor.authorHaas, S-
dc.contributor.authorWeitz, JI-
dc.contributor.authorGoldhaber, SZ-
dc.contributor.authorTurpie, AGG-
dc.contributor.authorGoto, S-
dc.contributor.authorAngchaisuksiri, P-
dc.contributor.authorNielsen, JD-
dc.contributor.authorKayani, G-
dc.contributor.authorPieper, KS-
dc.contributor.authorSchellong, S-
dc.contributor.authorBounameaux, H-
dc.contributor.authorMantovani, LG-
dc.contributor.authorPrandoni, P-
dc.contributor.authorKakkar, AK-
dc.contributor.authorYiu, KH-
dc.contributor.authorGARFIELD-VTE investigators-
dc.date.accessioned2020-09-22T03:00:08Z-
dc.date.available2020-09-22T03:00:08Z-
dc.date.issued2019-
dc.identifier.citationThrombosis and Haemostasis, 2019, v. 119 n. 2, p. 319-327-
dc.identifier.issn0340-6245-
dc.identifier.urihttp://hdl.handle.net/10722/287377-
dc.description.abstractBackground Management of venous thromboembolism (VTE), encompassing both deep vein thrombosis (DVT) and pulmonary embolism (PE), varies worldwide. Methods The Global Anticoagulant Registry in the FIELD – Venous Thromboembolism (GARFIELD-VTE) is a prospective, observational study of 10,685 patients with objectively diagnosed VTE recruited from May 2014 to January 2017 at 417 sites in 28 countries. All patients are followed for at least 3 years. We describe the baseline characteristics of the study population and their management within 30 days of diagnosis. Results The median age was 60.2 years; 50.4% were male; 61.7% had DVT and 38.3% had PE ± DVT; and 32.3% were obese (body mass index ≥ 30 kg/m2). The most common risk factors were surgery (12.5%), hospitalization (12.0%) and trauma to the lower limbs (7.8%). At the time of VTE diagnosis, 10.1% had active cancer and 5.7% were chronically immobilized. Treatment for VTE was anticoagulant (AC) therapy alone in 90.9% of patients; 5.1% received thrombolytic and/or surgical/mechanical therapy ± AC and 4.0% received no therapy. Pre-diagnosis, 12.8% received AC therapy alone and 0.2% received thrombolytic and/or surgical/mechanical therapy ± AC. After diagnosis, parenteral AC therapy alone was administered in 17.6% of patients, and it was followed by a direct oral AC (DOAC) in 16.4% or a vitamin K antagonist (VKA) in 26.8%. DOACs alone were prescribed to 32.3% of patients, while 5.9% received VKA alone. Conclusion The initial findings from this global registry highlight the heterogeneity in characteristics and management of VTE patients. Prospective follow-up will reveal the impact of this heterogeneity on outcomes.-
dc.languageeng-
dc.publisherSchattauer GmbH. The Journal's web site is located at http://www.thrombosis-online.com-
dc.relation.ispartofThrombosis and Haemostasis-
dc.subjectvenous thromboembolism-
dc.subjectregistry-
dc.subjectdeep vein thrombosis-
dc.subjectpulmonary embolism-
dc.subjectanticoagulation-
dc.titleCharacteristics and Management of Patients with Venous Thromboembolism: The GARFIELD-VTE Registry-
dc.typeArticle-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.authorityYiu, KH=rp01490-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1055/s-0038-1676611-
dc.identifier.pmid30593086-
dc.identifier.scopuseid_2-s2.0-85060367126-
dc.identifier.hkuros314362-
dc.identifier.volume119-
dc.identifier.issue2-
dc.identifier.spage319-
dc.identifier.epage327-
dc.identifier.isiWOS:000458811700015-
dc.publisher.placeGermany-
dc.identifier.issnl0340-6245-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats