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- Publisher Website: 10.1016/j.pharmthera.2019.107465
- Scopus: eid_2-s2.0-85076962259
- PMID: 31863819
- WOS: WOS:000520609600011
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Article: The past, present and future perspectives of matrix metalloproteinase inhibitors
Title | The past, present and future perspectives of matrix metalloproteinase inhibitors |
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Authors | |
Keywords | Matrix metalloproteinase MMP Inhibitor MMPI |
Issue Date | 2020 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmthera |
Citation | Pharmacology & Therapeutics, 2020, v. 207, article no. 107465 How to Cite? |
Abstract | Matrix metalloproteinases (MMPs) are a large family of enzymes that degrade the extracellular matrix (ECM). Under pathologic conditions, overexpression of MMPs or insufficient control by tissue inhibitors of MMPs (TIMPs) results in the dysregulation of tissue remodeling and causes a variety of diseases such as encephalomyelitis, rheumatoid arthritis, Alzheimer's disease and tumors. Therefore, the high affinity of MMPs for biomolecules renders them attractive targets for inhibition when homeostasis breaks down in the ECM. There are 4 generations of MMP inhibitors (MMPIs), ranging from small molecules or peptides to antibodies and protein-engineered inhibitors of metalloproteinase. Although a plethora of MMPIs has been synthesized, most of them have failed in clinical trials or are still in the laboratory stage of development. The present review summarizes the development of MMPIs, their associated problems and discusses future directions for the development of the future generations of MMPIs. |
Persistent Identifier | http://hdl.handle.net/10722/287140 |
ISSN | 2023 Impact Factor: 12.0 2023 SCImago Journal Rankings: 3.150 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, K | - |
dc.contributor.author | Tay, FR | - |
dc.contributor.author | Yiu, CKY | - |
dc.date.accessioned | 2020-09-22T02:56:23Z | - |
dc.date.available | 2020-09-22T02:56:23Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Pharmacology & Therapeutics, 2020, v. 207, article no. 107465 | - |
dc.identifier.issn | 0163-7258 | - |
dc.identifier.uri | http://hdl.handle.net/10722/287140 | - |
dc.description.abstract | Matrix metalloproteinases (MMPs) are a large family of enzymes that degrade the extracellular matrix (ECM). Under pathologic conditions, overexpression of MMPs or insufficient control by tissue inhibitors of MMPs (TIMPs) results in the dysregulation of tissue remodeling and causes a variety of diseases such as encephalomyelitis, rheumatoid arthritis, Alzheimer's disease and tumors. Therefore, the high affinity of MMPs for biomolecules renders them attractive targets for inhibition when homeostasis breaks down in the ECM. There are 4 generations of MMP inhibitors (MMPIs), ranging from small molecules or peptides to antibodies and protein-engineered inhibitors of metalloproteinase. Although a plethora of MMPIs has been synthesized, most of them have failed in clinical trials or are still in the laboratory stage of development. The present review summarizes the development of MMPIs, their associated problems and discusses future directions for the development of the future generations of MMPIs. | - |
dc.language | eng | - |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmthera | - |
dc.relation.ispartof | Pharmacology & Therapeutics | - |
dc.subject | Matrix metalloproteinase | - |
dc.subject | MMP | - |
dc.subject | Inhibitor | - |
dc.subject | MMPI | - |
dc.title | The past, present and future perspectives of matrix metalloproteinase inhibitors | - |
dc.type | Article | - |
dc.identifier.email | Tay, FR: franktay@hkucc.hku.hk | - |
dc.identifier.email | Yiu, CKY: ckyyiu@hkucc.hku.hk | - |
dc.identifier.authority | Yiu, CKY=rp00018 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.pharmthera.2019.107465 | - |
dc.identifier.pmid | 31863819 | - |
dc.identifier.scopus | eid_2-s2.0-85076962259 | - |
dc.identifier.hkuros | 314436 | - |
dc.identifier.volume | 207 | - |
dc.identifier.spage | article no. 107465 | - |
dc.identifier.epage | article no. 107465 | - |
dc.identifier.isi | WOS:000520609600011 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0163-7258 | - |