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Article: Elevated H3K27ac in aged skeletal muscle leads to increase in extracellular matrix and fibrogenic conversion of muscle satellite cells

TitleElevated H3K27ac in aged skeletal muscle leads to increase in extracellular matrix and fibrogenic conversion of muscle satellite cells
Authors
Keywordsaging
enhancer
extracellular matrix
H3K27ac
JQ1
Issue Date2019
PublisherWiley Open Access. The Journal's web site is located at https://onlinelibrary.wiley.com/journal/14749726
Citation
Aging Cell, 2019, v. 18 n. 5, p. article no. e12996 How to Cite?
AbstractEpigenetic alterations occur in various cells and tissues during aging, but it is not known if such alterations are also associated with aging in skeletal muscle. Here, we examined the changes of a panel of histone modifications and found H3K27ac (an active enhancer mark) is markedly increased in aged human skeletal muscle tissues. Further analyses uncovered that the H3K27ac increase and enhancer activation are associated with the up‐regulation of extracellular matrix (ECM) genes; this may result in alteration of the niche environment for skeletal muscle stem cells, also called satellite cells (SCs), which causes decreased myogenic potential and fibrogenic conversion of SCs. In mice, treatment of aging muscles with JQ1, an inhibitor of enhancer activation, inhibited the ECM up‐regulation and fibrogenic conversion of SCs and restored their myogenic differentiation potential. Altogether, our findings not only uncovered a novel aspect of skeletal muscle aging that is associated with enhancer remodeling but also implicated JQ1 as a potential treatment approach for restoring SC function in aging muscle.
Persistent Identifierhttp://hdl.handle.net/10722/287133
ISSN
2019 Impact Factor: 7.238
2015 SCImago Journal Rankings: 4.374
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, J-
dc.contributor.authorSo, KK-
dc.contributor.authorLi, Y-
dc.contributor.authorLi, Y-
dc.contributor.authorYuan, J-
dc.contributor.authorDing, Y-
dc.contributor.authorChen, F-
dc.contributor.authorHuang, Y-
dc.contributor.authorLiu, J-
dc.contributor.authorLee, W-
dc.contributor.authorLi, G-
dc.contributor.authorJu, Z-
dc.contributor.authorSun, H-
dc.contributor.authorWang, H-
dc.date.accessioned2020-09-22T02:56:16Z-
dc.date.available2020-09-22T02:56:16Z-
dc.date.issued2019-
dc.identifier.citationAging Cell, 2019, v. 18 n. 5, p. article no. e12996-
dc.identifier.issn1474-9718-
dc.identifier.urihttp://hdl.handle.net/10722/287133-
dc.description.abstractEpigenetic alterations occur in various cells and tissues during aging, but it is not known if such alterations are also associated with aging in skeletal muscle. Here, we examined the changes of a panel of histone modifications and found H3K27ac (an active enhancer mark) is markedly increased in aged human skeletal muscle tissues. Further analyses uncovered that the H3K27ac increase and enhancer activation are associated with the up‐regulation of extracellular matrix (ECM) genes; this may result in alteration of the niche environment for skeletal muscle stem cells, also called satellite cells (SCs), which causes decreased myogenic potential and fibrogenic conversion of SCs. In mice, treatment of aging muscles with JQ1, an inhibitor of enhancer activation, inhibited the ECM up‐regulation and fibrogenic conversion of SCs and restored their myogenic differentiation potential. Altogether, our findings not only uncovered a novel aspect of skeletal muscle aging that is associated with enhancer remodeling but also implicated JQ1 as a potential treatment approach for restoring SC function in aging muscle.-
dc.languageeng-
dc.publisherWiley Open Access. The Journal's web site is located at https://onlinelibrary.wiley.com/journal/14749726-
dc.relation.ispartofAging Cell-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectaging-
dc.subjectenhancer-
dc.subjectextracellular matrix-
dc.subjectH3K27ac-
dc.subjectJQ1-
dc.titleElevated H3K27ac in aged skeletal muscle leads to increase in extracellular matrix and fibrogenic conversion of muscle satellite cells-
dc.typeArticle-
dc.identifier.emailSo, KK: kkhso@hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1111/acel.12996-
dc.identifier.pmid31325224-
dc.identifier.pmcidPMC6718601-
dc.identifier.scopuseid_2-s2.0-85071691115-
dc.identifier.scopuseid_2-s2.0-85071691115-
dc.identifier.hkuros314156-
dc.identifier.volume18-
dc.identifier.issue5-
dc.identifier.spagearticle no. e12996-
dc.identifier.epagearticle no. e12996-
dc.publisher.placeUnited Kingdom-

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