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Article: Long-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection

TitleLong-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection
Authors
KeywordsValganciclovir
Anterior uveitis
Antiviral
Cytomegalovirus infection
Endotheliitis
Inflammation
Ocular hypertension
Issue Date2012
Citation
Clinical Ophthalmology, 2012, v. 6, n. 1, p. 595-600 How to Cite?
AbstractBackground: The purpose of this study was to assess the efficacy of oral valganciclovir in the treatment of anterior segment inflammation caused by cytomegalovirus (CMV) infection. Methods: Consecutive patients with anterior segment inflammation due to CMV causing anterior uveitis or corneal endotheliitis treated with oral valganciclovir were reviewed. Diagnosis of CMV infection was confirmed by polymerase chain reaction of the aqueous aspirate prior to commencement of oral valganciclovir. All patients were treated with an oral loading dose of 900 mg valganciclovir twice daily for at least 2 weeks, followed by an additional 450 mg valganciclovir twice-daily maintenance therapy. Changes in visual acuity, intraocular pressure (IOP), use of antiglaucomatous eye drops, and recurrence were analyzed. Results: Thirteen eyes of 11 patients were followed for a mean of 17.2 months. Two patients had bilateral corneal endotheliitis. All eyes had absence of anterior segment inflammation within 3 weeks after treatment. Following treatment, the mean logMAR visual acuity improved significantly from 0.58 at baseline to 0.37 at the last follow-up (P = 0.048). The mean IOP and number of antiglaucomatous eye drops also decreased significantly (P = 0.021 and P = 0.004, respectively). Five (38.5%) eyes had recurrence of anterior uveitis after valganciclovir was stopped and required retreatment with oral valganciclovir. Conclusion: Oral valganciclovir appeared to be effective in controlling CMV anterior uveitis, resulting in visual improvement and IOP reduction following control of inflammation. However, despite the initial clinical response in all cases, recurrence after cessation of oral valganciclovir could occur. © 2012 Wong et al, publisher and licensee Dove Medical Press Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/286802
ISSN
2023 SCImago Journal Rankings: 0.911
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, Victoria W.Y.-
dc.contributor.authorChan, Carmen K.M.-
dc.contributor.authorLeung, Dexter Y.L.-
dc.contributor.authorLai, Timothy Y.Y.-
dc.date.accessioned2020-09-07T11:45:42Z-
dc.date.available2020-09-07T11:45:42Z-
dc.date.issued2012-
dc.identifier.citationClinical Ophthalmology, 2012, v. 6, n. 1, p. 595-600-
dc.identifier.issn1177-5467-
dc.identifier.urihttp://hdl.handle.net/10722/286802-
dc.description.abstractBackground: The purpose of this study was to assess the efficacy of oral valganciclovir in the treatment of anterior segment inflammation caused by cytomegalovirus (CMV) infection. Methods: Consecutive patients with anterior segment inflammation due to CMV causing anterior uveitis or corneal endotheliitis treated with oral valganciclovir were reviewed. Diagnosis of CMV infection was confirmed by polymerase chain reaction of the aqueous aspirate prior to commencement of oral valganciclovir. All patients were treated with an oral loading dose of 900 mg valganciclovir twice daily for at least 2 weeks, followed by an additional 450 mg valganciclovir twice-daily maintenance therapy. Changes in visual acuity, intraocular pressure (IOP), use of antiglaucomatous eye drops, and recurrence were analyzed. Results: Thirteen eyes of 11 patients were followed for a mean of 17.2 months. Two patients had bilateral corneal endotheliitis. All eyes had absence of anterior segment inflammation within 3 weeks after treatment. Following treatment, the mean logMAR visual acuity improved significantly from 0.58 at baseline to 0.37 at the last follow-up (P = 0.048). The mean IOP and number of antiglaucomatous eye drops also decreased significantly (P = 0.021 and P = 0.004, respectively). Five (38.5%) eyes had recurrence of anterior uveitis after valganciclovir was stopped and required retreatment with oral valganciclovir. Conclusion: Oral valganciclovir appeared to be effective in controlling CMV anterior uveitis, resulting in visual improvement and IOP reduction following control of inflammation. However, despite the initial clinical response in all cases, recurrence after cessation of oral valganciclovir could occur. © 2012 Wong et al, publisher and licensee Dove Medical Press Ltd.-
dc.languageeng-
dc.relation.ispartofClinical Ophthalmology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectValganciclovir-
dc.subjectAnterior uveitis-
dc.subjectAntiviral-
dc.subjectCytomegalovirus infection-
dc.subjectEndotheliitis-
dc.subjectInflammation-
dc.subjectOcular hypertension-
dc.titleLong-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.2147/OPTH.S30476-
dc.identifier.pmid22553419-
dc.identifier.pmcidPMC3340120-
dc.identifier.scopuseid_2-s2.0-84863491361-
dc.identifier.volume6-
dc.identifier.issue1-
dc.identifier.spage595-
dc.identifier.epage600-
dc.identifier.eissn1177-5483-
dc.identifier.isiWOS:000215903500095-
dc.identifier.issnl1177-5467-

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