File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Saliva electrolyte analysis and xerostomia-related quality of life in nasopharyngeal carcinoma patients following intensity-modulated radiation therapy

TitleSaliva electrolyte analysis and xerostomia-related quality of life in nasopharyngeal carcinoma patients following intensity-modulated radiation therapy
Authors
KeywordsNasopharyngeal carcinoma
Radiotherapy
Xerostomia
Saliva electrolytes
Issue Date2020
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/radonc
Citation
Radiotherapy & Oncology, 2020, v. 150, p. 97-103 How to Cite?
AbstractBackground and purpose Nasopharyngeal carcinoma (NPC) is one of the most common cancers in southern China and the first-line treatment is radiotherapy. Intensity-modulated radiation therapy (IMRT) can deliver high dose to cancer and low dose to normal tissue, but xerostomia is still one of the complications after IMRT. However, how the concentration of saliva electrolytes be affected by IMRT and the effects on the quality of life are still unknown. In this prospective study, 76 NPC patients were recruited from hospitals in Hong Kong to identify the change of saliva electrolytes and xerostomia-related quality of life before and after IMRT. Methods and materials Saliva and questionnaire were collected before IMRT, 1 month, 3 months, 6 months and 12 months after IMRT. The concentration of saliva electrolytes was detected using inductively coupled plasma-optical emission spectroscopy (ICP-OES). Results Saliva flow rate significantly decreased after IMRT. Decrease in the mean value of pH was observed but the difference is not statistically significant. The concentrations of potassium, iodine, and calcium decreased and chloride concentration increased after IMRT, while the concentrations of sodium, magnesium, copper or zinc were kept at the same level before and after treatment. Xerostomia-related quality of life was adversely affected by IMRT, but partially recovered after 1 year. Conclusions Our study revealed the change of saliva electrolytes and xerostomia-related quality of life in patients undergone IMRT for NPC.
Persistent Identifierhttp://hdl.handle.net/10722/286734
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.702
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLan, X-
dc.contributor.authorChan, JYK-
dc.contributor.authorPu, JJ-
dc.contributor.authorQiao, W-
dc.contributor.authorPang, S-
dc.contributor.authorYang, WF-
dc.contributor.authorWong, KCW-
dc.contributor.authorKwong, DLW-
dc.contributor.authorSu, YX-
dc.date.accessioned2020-09-04T13:29:35Z-
dc.date.available2020-09-04T13:29:35Z-
dc.date.issued2020-
dc.identifier.citationRadiotherapy & Oncology, 2020, v. 150, p. 97-103-
dc.identifier.issn0167-8140-
dc.identifier.urihttp://hdl.handle.net/10722/286734-
dc.description.abstractBackground and purpose Nasopharyngeal carcinoma (NPC) is one of the most common cancers in southern China and the first-line treatment is radiotherapy. Intensity-modulated radiation therapy (IMRT) can deliver high dose to cancer and low dose to normal tissue, but xerostomia is still one of the complications after IMRT. However, how the concentration of saliva electrolytes be affected by IMRT and the effects on the quality of life are still unknown. In this prospective study, 76 NPC patients were recruited from hospitals in Hong Kong to identify the change of saliva electrolytes and xerostomia-related quality of life before and after IMRT. Methods and materials Saliva and questionnaire were collected before IMRT, 1 month, 3 months, 6 months and 12 months after IMRT. The concentration of saliva electrolytes was detected using inductively coupled plasma-optical emission spectroscopy (ICP-OES). Results Saliva flow rate significantly decreased after IMRT. Decrease in the mean value of pH was observed but the difference is not statistically significant. The concentrations of potassium, iodine, and calcium decreased and chloride concentration increased after IMRT, while the concentrations of sodium, magnesium, copper or zinc were kept at the same level before and after treatment. Xerostomia-related quality of life was adversely affected by IMRT, but partially recovered after 1 year. Conclusions Our study revealed the change of saliva electrolytes and xerostomia-related quality of life in patients undergone IMRT for NPC.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/radonc-
dc.relation.ispartofRadiotherapy & Oncology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectNasopharyngeal carcinoma-
dc.subjectRadiotherapy-
dc.subjectXerostomia-
dc.subjectSaliva electrolytes-
dc.titleSaliva electrolyte analysis and xerostomia-related quality of life in nasopharyngeal carcinoma patients following intensity-modulated radiation therapy-
dc.typeArticle-
dc.identifier.emailKwong, DLW: dlwkwong@hku.hk-
dc.identifier.emailSu, YX: richsu@hku.hk-
dc.identifier.authorityKwong, DLW=rp00414-
dc.identifier.authoritySu, YX=rp01916-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.radonc.2020.06.016-
dc.identifier.pmid32544605-
dc.identifier.scopuseid_2-s2.0-85086937388-
dc.identifier.hkuros314045-
dc.identifier.hkuros316099-
dc.identifier.volume150-
dc.identifier.spage97-
dc.identifier.epage103-
dc.identifier.isiWOS:000629605200019-
dc.publisher.placeIreland-
dc.identifier.issnl0167-8140-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats