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Article: FTY720 suppresses liver tumor growth and metastasis by reducing circulating regulating T cells and enhancing the anti-tumor effect of rapamycin

TitleFTY720 suppresses liver tumor growth and metastasis by reducing circulating regulating T cells and enhancing the anti-tumor effect of rapamycin
Authors
KeywordsFTY720
Rapamycin
Regulatory T cells
Hepatic ischemia/reperfusion
Tumor recurrence
Issue Date2020
PublisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/oncotargets-and-therapy-journal
Citation
OncoTargets and Therapy, 2020, v. 13, p. 4743-4754 How to Cite?
AbstractBackground: In this study, we aimed to study the effect of FTY720 treatment in reducing circulating Tregs level and then suppressing liver tumor metastasis after hepatectomy and I/R injury in animal models. Furthermore, we also investigated the synergistic anti-tumor effect of FTY720 combined with rapamycin on hepatocellular carcinoma. Methods: The effect of FTY720 on suppressing Tregs mobilization and tumor metastasis after hepatectomy was investigated in an orthotopic liver tumor rat model with hepatectomy and hepatic ischemia/reperfusion (I/R) injury. The synergistic anti-tumor effect of FTY720 combined with rapamycin was further explored both in in vitro functional study and in orthotopic liver tumor mouse model. Results: In rat model, hepatic I/R promoted tumor metastasis and increased circulating Tregs after hepatectomy. The treatment of FTY720 reduced liver tumor metastasis and the number of circulating Tregs. Furthermore, FTY720 enhanced the anti-tumor capacity of rapamycin by inhibiting tumor cell proliferation and migration in vitro and reducing tumor growth in vivo through suppressing hepatic stellate cell activation and tumor angiogenesis. Conclusion: FTY720 suppressed liver tumor growth and metastasis by reducing the population of circulating Tregs and enhancing the anti-tumor effect of rapamycin. It was suggested that FTY720 single or combined with rapamycin might provide novel insight for suppressing tumor growth and metastasis for HCC patients.
Persistent Identifierhttp://hdl.handle.net/10722/286358
ISSN
2019 Impact Factor: 3.337
2015 SCImago Journal Rankings: 1.133
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, CX-
dc.contributor.authorYang, XX-
dc.contributor.authorWang, HW-
dc.contributor.authorLi, XC-
dc.contributor.authorNg, KTP-
dc.contributor.authorLo, CM-
dc.contributor.authorMan, K-
dc.date.accessioned2020-08-31T07:02:44Z-
dc.date.available2020-08-31T07:02:44Z-
dc.date.issued2020-
dc.identifier.citationOncoTargets and Therapy, 2020, v. 13, p. 4743-4754-
dc.identifier.issn1178-6930-
dc.identifier.urihttp://hdl.handle.net/10722/286358-
dc.description.abstractBackground: In this study, we aimed to study the effect of FTY720 treatment in reducing circulating Tregs level and then suppressing liver tumor metastasis after hepatectomy and I/R injury in animal models. Furthermore, we also investigated the synergistic anti-tumor effect of FTY720 combined with rapamycin on hepatocellular carcinoma. Methods: The effect of FTY720 on suppressing Tregs mobilization and tumor metastasis after hepatectomy was investigated in an orthotopic liver tumor rat model with hepatectomy and hepatic ischemia/reperfusion (I/R) injury. The synergistic anti-tumor effect of FTY720 combined with rapamycin was further explored both in in vitro functional study and in orthotopic liver tumor mouse model. Results: In rat model, hepatic I/R promoted tumor metastasis and increased circulating Tregs after hepatectomy. The treatment of FTY720 reduced liver tumor metastasis and the number of circulating Tregs. Furthermore, FTY720 enhanced the anti-tumor capacity of rapamycin by inhibiting tumor cell proliferation and migration in vitro and reducing tumor growth in vivo through suppressing hepatic stellate cell activation and tumor angiogenesis. Conclusion: FTY720 suppressed liver tumor growth and metastasis by reducing the population of circulating Tregs and enhancing the anti-tumor effect of rapamycin. It was suggested that FTY720 single or combined with rapamycin might provide novel insight for suppressing tumor growth and metastasis for HCC patients.-
dc.languageeng-
dc.publisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/oncotargets-and-therapy-journal-
dc.relation.ispartofOncoTargets and Therapy-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectFTY720-
dc.subjectRapamycin-
dc.subjectRegulatory T cells-
dc.subjectHepatic ischemia/reperfusion-
dc.subjectTumor recurrence-
dc.titleFTY720 suppresses liver tumor growth and metastasis by reducing circulating regulating T cells and enhancing the anti-tumor effect of rapamycin-
dc.typeArticle-
dc.identifier.emailNg, KTP: ledodes@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.emailMan, K: kwanman@hku.hk-
dc.identifier.authorityNg, KTP=rp01720-
dc.identifier.authorityLo, CM=rp00412-
dc.identifier.authorityMan, K=rp00417-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.2147/OTT.S234394-
dc.identifier.pmid32547103-
dc.identifier.pmcidPMC7262652-
dc.identifier.scopuseid_2-s2.0-85085556010-
dc.identifier.hkuros313695-
dc.identifier.volume13-
dc.identifier.spage4743-
dc.identifier.epage4754-
dc.identifier.isiWOS:000535240700001-
dc.publisher.placeUnited Kingdom-

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