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Article: M2 macrophages on tumour growth and metastasis in hepatocellular carcinoma
| Title | M2 macrophages on tumour growth and metastasis in hepatocellular carcinoma |
|---|---|
| Authors | |
| Issue Date | 2019 |
| Publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/ |
| Citation | Hong Kong Medical Journal, 2019, v. 25 n. 6, suppl. 9, p. S35-S39 How to Cite? |
| Abstract | 1. M2 macrophages contributed to poor survival outcome in liver cancer patients. An increase in the number of immune cells within the tumour correlated with reduction in the overall and relapse-free survival period.
2. An increase in M2 macrophages correlated with larger tumour size, increased venous infiltration, and higher tumour stage.
3. M2 macrophages secreted a chemokine CCL22 that promoted invasiveness of liver cancer cells and increased the incidence of metastasis.
4. Targeting the tumour-promoting macrophages is a potential therapeutic strategy against liver cancer. |
| Description | HMRF project number: 01122266 |
| Persistent Identifier | http://hdl.handle.net/10722/286357 |
| ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.261 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Man, K | - |
| dc.contributor.author | Lo, CM | - |
| dc.contributor.author | Liu, XB | - |
| dc.date.accessioned | 2020-08-31T07:02:44Z | - |
| dc.date.available | 2020-08-31T07:02:44Z | - |
| dc.date.issued | 2019 | - |
| dc.identifier.citation | Hong Kong Medical Journal, 2019, v. 25 n. 6, suppl. 9, p. S35-S39 | - |
| dc.identifier.issn | 1024-2708 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/286357 | - |
| dc.description | HMRF project number: 01122266 | - |
| dc.description.abstract | 1. M2 macrophages contributed to poor survival outcome in liver cancer patients. An increase in the number of immune cells within the tumour correlated with reduction in the overall and relapse-free survival period. 2. An increase in M2 macrophages correlated with larger tumour size, increased venous infiltration, and higher tumour stage. 3. M2 macrophages secreted a chemokine CCL22 that promoted invasiveness of liver cancer cells and increased the incidence of metastasis. 4. Targeting the tumour-promoting macrophages is a potential therapeutic strategy against liver cancer. | - |
| dc.language | eng | - |
| dc.publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/ | - |
| dc.relation.ispartof | Hong Kong Medical Journal | - |
| dc.title | M2 macrophages on tumour growth and metastasis in hepatocellular carcinoma | - |
| dc.type | Article | - |
| dc.identifier.email | Man, K: kwanman@hku.hk | - |
| dc.identifier.email | Lo, CM: chungmlo@hkucc.hku.hk | - |
| dc.identifier.email | Liu, XB: liuxb301@hku.hk | - |
| dc.identifier.authority | Man, K=rp00417 | - |
| dc.identifier.authority | Lo, CM=rp00412 | - |
| dc.description.nature | link_to_OA_fulltext | - |
| dc.identifier.pmid | 31889034 | - |
| dc.identifier.scopus | eid_2-s2.0-85077345678 | - |
| dc.identifier.hkuros | 313694 | - |
| dc.identifier.volume | 25 | - |
| dc.identifier.issue | 6, suppl. 9 | - |
| dc.identifier.spage | S35 | - |
| dc.identifier.epage | S39 | - |
| dc.publisher.place | Hong Kong | - |
| dc.identifier.issnl | 1024-2708 | - |