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Article: Dual release of VEGF and PDGF from emulsion electrospun bilayer scaffolds consisting of orthogonally aligned nanofibers for gastrointestinal tract regeneration
Title | Dual release of VEGF and PDGF from emulsion electrospun bilayer scaffolds consisting of orthogonally aligned nanofibers for gastrointestinal tract regeneration |
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Authors | |
Keywords | Cell engineering Emulsification Endothelial cells Nanofibers Scaffolds (biology) |
Issue Date | 2019 |
Publisher | Cambridge University Press. The Journal's web site is located at https://www.cambridge.org/core/journals/mrs-communications |
Citation | MRS Communications, 2019, v. 9 n. 3, p. 1098-1104 How to Cite? |
Abstract | The regeneration of human tissues with complex anatomy such as gastrointestinal (GI) tract remains greatly challenging since it requires appropriate cell microenvironments with well-defined structural and biochemical cues. In this investigation, bilayer scaffolds consisting of different polymer nanofibers with orthogonal fiber orientations were prepared, in which vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) were encapsulated separately. The bilayer scaffolds have similar architecture to the anatomy of the GI tract and can achieve dual releases of VEGF and PDGF in sequential and sustained manners, which hold promise as appropriate cell microenvironments for promoting the regeneration of the GI tract. |
Persistent Identifier | http://hdl.handle.net/10722/286230 |
ISSN | 2023 Impact Factor: 1.8 2023 SCImago Journal Rankings: 0.390 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | ZHOU, Y | - |
dc.contributor.author | Zhao, Q | - |
dc.contributor.author | Wang, M | - |
dc.date.accessioned | 2020-08-31T07:01:00Z | - |
dc.date.available | 2020-08-31T07:01:00Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | MRS Communications, 2019, v. 9 n. 3, p. 1098-1104 | - |
dc.identifier.issn | 2159-6859 | - |
dc.identifier.uri | http://hdl.handle.net/10722/286230 | - |
dc.description.abstract | The regeneration of human tissues with complex anatomy such as gastrointestinal (GI) tract remains greatly challenging since it requires appropriate cell microenvironments with well-defined structural and biochemical cues. In this investigation, bilayer scaffolds consisting of different polymer nanofibers with orthogonal fiber orientations were prepared, in which vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) were encapsulated separately. The bilayer scaffolds have similar architecture to the anatomy of the GI tract and can achieve dual releases of VEGF and PDGF in sequential and sustained manners, which hold promise as appropriate cell microenvironments for promoting the regeneration of the GI tract. | - |
dc.language | eng | - |
dc.publisher | Cambridge University Press. The Journal's web site is located at https://www.cambridge.org/core/journals/mrs-communications | - |
dc.relation.ispartof | MRS Communications | - |
dc.rights | MRS Communications. Copyright © Cambridge University Press. | - |
dc.rights | This article has been published in a revised form in [Journal] [http://doi.org/XXX]. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © copyright holder. | - |
dc.subject | Cell engineering | - |
dc.subject | Emulsification | - |
dc.subject | Endothelial cells | - |
dc.subject | Nanofibers | - |
dc.subject | Scaffolds (biology) | - |
dc.title | Dual release of VEGF and PDGF from emulsion electrospun bilayer scaffolds consisting of orthogonally aligned nanofibers for gastrointestinal tract regeneration | - |
dc.type | Article | - |
dc.identifier.email | Wang, M: memwang@hku.hk | - |
dc.identifier.authority | Wang, M=rp00185 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1557/mrc.2019.104 | - |
dc.identifier.scopus | eid_2-s2.0-85070353517 | - |
dc.identifier.hkuros | 313800 | - |
dc.identifier.volume | 9 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 1098 | - |
dc.identifier.epage | 1104 | - |
dc.identifier.isi | WOS:000488237800041 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 2159-6867 | - |