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Article: Time‐Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE‐Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation

TitleTime‐Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE‐Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation
Authors
Keywordsaggregation-induced emission
anion–π+ interactions
antibacterial cancer cells
multiple and ordered targeting
Issue Date2020
PublisherWiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
Citation
Angewandte Chemie (International Edition), 2020, v. 59 n. 24, p. 9470-9477 How to Cite?
AbstractPathogen infections and cancer are two major human health problems. Herein, we report the synthesis of an organic salt photosensitizer (PS), called 4TPA‐BQ, by a one‐step reaction. 4TPA‐BQ presents aggregation‐induced emission features. Owing to the aggregation‐induced reactive oxygen species generated and a sufficiently small ΔEST, 4TPA‐BQ shows a satisfactorily high 1O2 generation efficiency of 97.8 %. In vitro and in vivo experiments confirmed that 4TPA‐BQ exhibited potent photodynamic antibacterial performance against ampicillin‐resistant Escherichia coli with good biocompatibility in a short time (15 minutes). When the incubation duration persisted long enough (12 hours), cancer cells were ablated efficiently, leaving normal cells essentially unaffected. This is the first reported time‐dependent fluorescence‐guided photodynamic therapy in one individual PS, which achieves ordered and multiple targeting simply by varying the external conditions. 4TPA‐BQ reveals new design principles for the implementation of efficient PSs in clinical applications.
Persistent Identifierhttp://hdl.handle.net/10722/286174
ISSN
2020 Impact Factor: 15.336
2015 SCImago Journal Rankings: 6.229
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Q-
dc.contributor.authorLi, Y-
dc.contributor.authorMin, T-
dc.contributor.authorGong, J-
dc.contributor.authorDu, L-
dc.contributor.authorPhillips, DL-
dc.contributor.authorLiu, J-
dc.contributor.authorLam, JWY-
dc.contributor.authorSung, HHY-
dc.contributor.authorWilliams, ID-
dc.contributor.authorKwok, RTK-
dc.contributor.authorHo, CL-
dc.contributor.authorLi, K-
dc.contributor.authorWang, J-
dc.contributor.authorTang, BZ-
dc.date.accessioned2020-08-31T07:00:11Z-
dc.date.available2020-08-31T07:00:11Z-
dc.date.issued2020-
dc.identifier.citationAngewandte Chemie (International Edition), 2020, v. 59 n. 24, p. 9470-9477-
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/10722/286174-
dc.description.abstractPathogen infections and cancer are two major human health problems. Herein, we report the synthesis of an organic salt photosensitizer (PS), called 4TPA‐BQ, by a one‐step reaction. 4TPA‐BQ presents aggregation‐induced emission features. Owing to the aggregation‐induced reactive oxygen species generated and a sufficiently small ΔEST, 4TPA‐BQ shows a satisfactorily high 1O2 generation efficiency of 97.8 %. In vitro and in vivo experiments confirmed that 4TPA‐BQ exhibited potent photodynamic antibacterial performance against ampicillin‐resistant Escherichia coli with good biocompatibility in a short time (15 minutes). When the incubation duration persisted long enough (12 hours), cancer cells were ablated efficiently, leaving normal cells essentially unaffected. This is the first reported time‐dependent fluorescence‐guided photodynamic therapy in one individual PS, which achieves ordered and multiple targeting simply by varying the external conditions. 4TPA‐BQ reveals new design principles for the implementation of efficient PSs in clinical applications.-
dc.languageeng-
dc.publisherWiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home-
dc.relation.ispartofAngewandte Chemie (International Edition)-
dc.rightsThis is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectaggregation-induced emission-
dc.subjectanion–π+ interactions-
dc.subjectantibacterial cancer cells-
dc.subjectmultiple and ordered targeting-
dc.titleTime‐Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE‐Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation-
dc.typeArticle-
dc.identifier.emailDu, L: ailleen@hku.hk-
dc.identifier.emailPhillips, DL: phillips@hku.hk-
dc.identifier.authorityPhillips, DL=rp00770-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/anie.201909706-
dc.identifier.pmid31557385-
dc.identifier.scopuseid_2-s2.0-85074501946-
dc.identifier.hkuros313835-
dc.identifier.volume59-
dc.identifier.issue24-
dc.identifier.spage9470-
dc.identifier.epage9477-
dc.identifier.isiWOS:000491834500001-
dc.publisher.placeGermany-
dc.identifier.issnl1433-7851-

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