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Article: Remineralising Dentine Caries Using Sodium Fluoride with Silver Nanoparticles: An In Vitro Study

TitleRemineralising Dentine Caries Using Sodium Fluoride with Silver Nanoparticles: An In Vitro Study
Authors
Keywordssilver
nanoparticles
fluoride
dentine
caries
Issue Date2020
PublisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=5
Citation
International Journal of Nanomedicine, 2020, v. 15, p. 2829-2839 How to Cite?
AbstractObjective: To investigate the remineralizing and staining effects of sodium fluoride (NaF) solution with polyethylene glycol-coated silver nanoparticles (PEG-AgNPs) on artificial dentine caries. Materials and Methods: Demineralized human dentine blocks were allocated to three groups. The blocks in group 1 underwent a topical application of a 12% silver diamine fluoride (SDF, 14,150 ppm fluoride) solution. The blocks in group 2 received a topical application of a 2.5% NaF (11,310 ppm fluoride) with PEG-AgNPs (400 ppm silver). The blocks in group 3 received deionized water. All blocks were subjected to pH cycling for 8 days. The surface morphology and cross-sectional features were investigated using scanning electron microscopy (SEM). The color parameters, crystal characteristics, lesion depth, and collagen degradation of the blocks were assessed using digital spectrophotometry, X-ray diffraction (XRD), micro-computed tomography, and spectrophotometry with a hydroxyproline assay, respectively. Results: The SEM showed that dentine collagen was exposed in group 3 but not in groups 1 and 2. The mean lesion depths in groups 1 to 3 were 118± 7 μm, 121± 14 μm, and 339± 20 μm, respectively (groups1,2< 3; p< 0.001). The data indicated that fluoridated PEG-AgNPs introduced no significant color effect on dentine, but SDF caused distinct discoloration. The XRD indicated that silver chloride was formed in group 1, and fluorapatite was detected in groups 1 and 2. The concentration of hydroxyproline liberated from collagen was significantly less in groups 1 and 2 than in group 3. Conclusion: The use of NaF solution with PEG-AgNPs can remineralize artificial dentine caries and inhibit collagen degradation without causing significant tooth staining.
Persistent Identifierhttp://hdl.handle.net/10722/286146
ISSN
2010 Impact Factor: 4.976
2023 SCImago Journal Rankings: 1.273
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhao, IS-
dc.contributor.authorYin, IX-
dc.contributor.authorMei, ML-
dc.contributor.authorLo, ECM-
dc.contributor.authorTang, J-
dc.contributor.authorLi, Q-
dc.contributor.authorSo, LY-
dc.contributor.authorChu, CH-
dc.date.accessioned2020-08-31T06:59:47Z-
dc.date.available2020-08-31T06:59:47Z-
dc.date.issued2020-
dc.identifier.citationInternational Journal of Nanomedicine, 2020, v. 15, p. 2829-2839-
dc.identifier.issn1176-9114-
dc.identifier.urihttp://hdl.handle.net/10722/286146-
dc.description.abstractObjective: To investigate the remineralizing and staining effects of sodium fluoride (NaF) solution with polyethylene glycol-coated silver nanoparticles (PEG-AgNPs) on artificial dentine caries. Materials and Methods: Demineralized human dentine blocks were allocated to three groups. The blocks in group 1 underwent a topical application of a 12% silver diamine fluoride (SDF, 14,150 ppm fluoride) solution. The blocks in group 2 received a topical application of a 2.5% NaF (11,310 ppm fluoride) with PEG-AgNPs (400 ppm silver). The blocks in group 3 received deionized water. All blocks were subjected to pH cycling for 8 days. The surface morphology and cross-sectional features were investigated using scanning electron microscopy (SEM). The color parameters, crystal characteristics, lesion depth, and collagen degradation of the blocks were assessed using digital spectrophotometry, X-ray diffraction (XRD), micro-computed tomography, and spectrophotometry with a hydroxyproline assay, respectively. Results: The SEM showed that dentine collagen was exposed in group 3 but not in groups 1 and 2. The mean lesion depths in groups 1 to 3 were 118± 7 μm, 121± 14 μm, and 339± 20 μm, respectively (groups1,2< 3; p< 0.001). The data indicated that fluoridated PEG-AgNPs introduced no significant color effect on dentine, but SDF caused distinct discoloration. The XRD indicated that silver chloride was formed in group 1, and fluorapatite was detected in groups 1 and 2. The concentration of hydroxyproline liberated from collagen was significantly less in groups 1 and 2 than in group 3. Conclusion: The use of NaF solution with PEG-AgNPs can remineralize artificial dentine caries and inhibit collagen degradation without causing significant tooth staining.-
dc.languageeng-
dc.publisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=5-
dc.relation.ispartofInternational Journal of Nanomedicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectsilver-
dc.subjectnanoparticles-
dc.subjectfluoride-
dc.subjectdentine-
dc.subjectcaries-
dc.titleRemineralising Dentine Caries Using Sodium Fluoride with Silver Nanoparticles: An In Vitro Study-
dc.typeArticle-
dc.identifier.emailLo, ECM: edward-lo@hku.hk-
dc.identifier.emailTang, J: jinyao@hku.hk-
dc.identifier.emailChu, CH: chchu@hku.hk-
dc.identifier.authorityLo, ECM=rp00015-
dc.identifier.authorityTang, J=rp01677-
dc.identifier.authorityChu, CH=rp00022-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.2147/IJN.S247550-
dc.identifier.pmid32368057-
dc.identifier.pmcidPMC7185692-
dc.identifier.scopuseid_2-s2.0-85083998034-
dc.identifier.hkuros313559-
dc.identifier.volume15-
dc.identifier.spage2829-
dc.identifier.epage2839-
dc.identifier.isiWOS:000527476500001-
dc.publisher.placeNew Zealand-
dc.identifier.issnl1176-9114-

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