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Article: Synthesis and Characterization of Fluoridated Silver Nanoparticles and Their Potential as a Non-Staining Anti-Caries Agent

TitleSynthesis and Characterization of Fluoridated Silver Nanoparticles and Their Potential as a Non-Staining Anti-Caries Agent
Authors
Keywordssilver
nanoparticles
fluoride
dentin
caries
Issue Date2020
PublisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=5
Citation
International Journal of Nanomedicine, 2020, v. 15, p. 3207-3215 How to Cite?
AbstractObjectives: The first objective of this study was to prepare sodium fluoride (NaF) solution with various concentrations of polyethylene glycol-coated silver nanoparticles (PEG-AgNPs). The second objective was to study the antibacterial activity against Streptococcus mutans and the tooth-staining effect of the solution. Methods: PEG-AgNPs were prepared via the one-step chemical reduction of silver acetate with thiolated polyethylene glycol. The PEG-AgNPs were characterized with ultraviolet-visible spectrometry and transmission electron microscopy. The half maximal inhibitory concentration (IC50) for the PEG-AgNPs against Streptococcus mutans and human gingival fibroblasts (HGF-1) were determined. The staining effect on dentin and enamel for the 2.5% NaF solutions with PEG-AgNPs at 12,800, 6400, 1600, and 400 ppm was investigated using digital spectrophotometry. The IC50 of the fluoridated silver nanoparticles against Streptococcus mutans were measured. Results: The PEG-AgNPs have an average diameter of 2.56± 0.43 nm and showed excellent stability at high ionic strength (2.5% NaF) for 18 months. The IC50 of PEG-AgNPs against Streptococcus mutans was found to be 21.16± 1.08 ppm silver, which was half of IC50 against HGF-1 cells (42.36± 1.12 ppm), providing a working range to kill bacteria with no harm to human cells. The formulations with different concentrations of PEG-AgNPs showed no significant staining of teeth. Combining PEG-AgNPs with NaF significantly expanded the therapeutic window against Streptococcus mutans by reducing its IC50. Conclusion: A biocompatible solution of NaF with PEG-AgNPs was developed. Because it has antibacterial activity against Streptococcus mutans and no tooth-staining effect, it can be used as an anti-caries agent.
Persistent Identifierhttp://hdl.handle.net/10722/286145
ISSN
2010 Impact Factor: 4.976
2015 SCImago Journal Rankings: 1.351
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorYin, IX-
dc.contributor.authorZhao, IS-
dc.contributor.authorMei, ML-
dc.contributor.authorLo, ECM-
dc.contributor.authorTang, J-
dc.contributor.authorLi, Q-
dc.contributor.authorSo, LY-
dc.contributor.authorChu, CH-
dc.date.accessioned2020-08-31T06:59:46Z-
dc.date.available2020-08-31T06:59:46Z-
dc.date.issued2020-
dc.identifier.citationInternational Journal of Nanomedicine, 2020, v. 15, p. 3207-3215-
dc.identifier.issn1176-9114-
dc.identifier.urihttp://hdl.handle.net/10722/286145-
dc.description.abstractObjectives: The first objective of this study was to prepare sodium fluoride (NaF) solution with various concentrations of polyethylene glycol-coated silver nanoparticles (PEG-AgNPs). The second objective was to study the antibacterial activity against Streptococcus mutans and the tooth-staining effect of the solution. Methods: PEG-AgNPs were prepared via the one-step chemical reduction of silver acetate with thiolated polyethylene glycol. The PEG-AgNPs were characterized with ultraviolet-visible spectrometry and transmission electron microscopy. The half maximal inhibitory concentration (IC50) for the PEG-AgNPs against Streptococcus mutans and human gingival fibroblasts (HGF-1) were determined. The staining effect on dentin and enamel for the 2.5% NaF solutions with PEG-AgNPs at 12,800, 6400, 1600, and 400 ppm was investigated using digital spectrophotometry. The IC50 of the fluoridated silver nanoparticles against Streptococcus mutans were measured. Results: The PEG-AgNPs have an average diameter of 2.56± 0.43 nm and showed excellent stability at high ionic strength (2.5% NaF) for 18 months. The IC50 of PEG-AgNPs against Streptococcus mutans was found to be 21.16± 1.08 ppm silver, which was half of IC50 against HGF-1 cells (42.36± 1.12 ppm), providing a working range to kill bacteria with no harm to human cells. The formulations with different concentrations of PEG-AgNPs showed no significant staining of teeth. Combining PEG-AgNPs with NaF significantly expanded the therapeutic window against Streptococcus mutans by reducing its IC50. Conclusion: A biocompatible solution of NaF with PEG-AgNPs was developed. Because it has antibacterial activity against Streptococcus mutans and no tooth-staining effect, it can be used as an anti-caries agent.-
dc.languageeng-
dc.publisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=5-
dc.relation.ispartofInternational Journal of Nanomedicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectsilver-
dc.subjectnanoparticles-
dc.subjectfluoride-
dc.subjectdentin-
dc.subjectcaries-
dc.titleSynthesis and Characterization of Fluoridated Silver Nanoparticles and Their Potential as a Non-Staining Anti-Caries Agent-
dc.typeArticle-
dc.identifier.emailLo, ECM: edward-lo@hku.hk-
dc.identifier.emailTang, J: jinyao@hku.hk-
dc.identifier.emailChu, CH: chchu@hku.hk-
dc.identifier.authorityLo, ECM=rp00015-
dc.identifier.authorityTang, J=rp01677-
dc.identifier.authorityChu, CH=rp00022-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.2147/IJN.S243202-
dc.identifier.pmid32440119-
dc.identifier.pmcidPMC7212993-
dc.identifier.scopuseid_2-s2.0-85085049833-
dc.identifier.hkuros313558-
dc.identifier.volume15-
dc.identifier.spage3207-
dc.identifier.epage3215-
dc.publisher.placeNew Zealand-

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