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Article: Low-level laser-aided orthodontic treatment of periodontally compromised patients: a randomised controlled trial

TitleLow-level laser-aided orthodontic treatment of periodontally compromised patients: a randomised controlled trial
Authors
KeywordsLow-level laser irradiation
Orthodontic-periodontal joint treatment
Randomised clinical trial
Orthodontic pain
Periodontal inflammation
Issue Date2020
PublisherSpringer-Verlag London Ltd. The Journal's web site is located at http://link.springer-ny.com/link/service/journals/10103/index.htm
Citation
Lasers in Medical Science, 2020, v. 35 n. 3, p. 729-739 How to Cite?
AbstractLow-level laser irradiation (LLLI) shows effects in orthodontic pain relief and periodontal inflammation control. The aim of this article is to investigate the analgesic and inflammation-modulatory effects of low-level laser irradiation among orthodontic patients with compromised periodontium. A randomised controlled trial with split-mouth design was conducted in 27 adults with treated and controlled chronic periodontitis over 6 months. One side of the dental arch underwent repeated treatment under a 940-nm diode laser (EZlase; Biolase Technology Inc.) with a beam size of 2.8 cm2 for 60 seconds at 8.6 J/cm2, whilst the other side received pseudo-laser treatment. Laser irradiation was applied repeatedly for 8 times during the first 6 weeks after bracket bonding and monthly thereafter until the end of orthodontic treatment. Subjective pain (assessed by visual analogue scale in pain diary and by chairside archwire activation), periodontal status (assessed by periodontal clinical parameters), cytokines in gingival crevicular fluid (interleukin 1β, prostaglandin E2, substance P) and periodontopathic bacteria (Porphyromonas gingivalis and Treponema denticola) in supragingival plaque were assessed. The intensity of pain was lower on the laser-irradiated side at multiple follow-up visits (P < 0.05). The pain subsided 1 day earlier on the laser side, with a lower peak value during the first week after initial archwire placement (P < 0.05). The laser side exhibited a smaller reduction in bite force during the first month (mean difference = 3.17, 95% CI: 2.36–3.98, P < 0.05 at 1-week interval; mean difference = 3.09, 95% CI: 1.87–4.32, P < 0.05 at 1-month interval). A smaller increase was observed in the plaque index scores on the laser side at 1-month (mean difference = 0.19, 95% CI: 0.13–0.24, P < 0.05) and in the gingival index scores at the 3-month follow-up visit (mean difference = 0.18, 95% CI: 0.14–0.21, P < 0.05). Laser irradiation inhibited the elevation of interleukin-1β, prostaglandin E2 and substance P levels during the first month (P < 0.05). However, no intergroup difference was detected in the bacteria levels. Low-level laser irradiation exhibits benefits in pain relief and inflammation control during the early stage of adjunctive orthodontic treatment in periodontally compromised individuals.
Persistent Identifierhttp://hdl.handle.net/10722/286143
ISSN
2023 Impact Factor: 2.1
2023 SCImago Journal Rankings: 0.575
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRen, C-
dc.contributor.authorMcGrath, C-
dc.contributor.authorGu, M-
dc.contributor.authorJin, L-
dc.contributor.authorZhang, C-
dc.contributor.authorSum, FHKMH-
dc.contributor.authorWong, KWF-
dc.contributor.authorChau, ACM-
dc.contributor.authorYang, Y-
dc.date.accessioned2020-08-31T06:59:44Z-
dc.date.available2020-08-31T06:59:44Z-
dc.date.issued2020-
dc.identifier.citationLasers in Medical Science, 2020, v. 35 n. 3, p. 729-739-
dc.identifier.issn0268-8921-
dc.identifier.urihttp://hdl.handle.net/10722/286143-
dc.description.abstractLow-level laser irradiation (LLLI) shows effects in orthodontic pain relief and periodontal inflammation control. The aim of this article is to investigate the analgesic and inflammation-modulatory effects of low-level laser irradiation among orthodontic patients with compromised periodontium. A randomised controlled trial with split-mouth design was conducted in 27 adults with treated and controlled chronic periodontitis over 6 months. One side of the dental arch underwent repeated treatment under a 940-nm diode laser (EZlase; Biolase Technology Inc.) with a beam size of 2.8 cm2 for 60 seconds at 8.6 J/cm2, whilst the other side received pseudo-laser treatment. Laser irradiation was applied repeatedly for 8 times during the first 6 weeks after bracket bonding and monthly thereafter until the end of orthodontic treatment. Subjective pain (assessed by visual analogue scale in pain diary and by chairside archwire activation), periodontal status (assessed by periodontal clinical parameters), cytokines in gingival crevicular fluid (interleukin 1β, prostaglandin E2, substance P) and periodontopathic bacteria (Porphyromonas gingivalis and Treponema denticola) in supragingival plaque were assessed. The intensity of pain was lower on the laser-irradiated side at multiple follow-up visits (P < 0.05). The pain subsided 1 day earlier on the laser side, with a lower peak value during the first week after initial archwire placement (P < 0.05). The laser side exhibited a smaller reduction in bite force during the first month (mean difference = 3.17, 95% CI: 2.36–3.98, P < 0.05 at 1-week interval; mean difference = 3.09, 95% CI: 1.87–4.32, P < 0.05 at 1-month interval). A smaller increase was observed in the plaque index scores on the laser side at 1-month (mean difference = 0.19, 95% CI: 0.13–0.24, P < 0.05) and in the gingival index scores at the 3-month follow-up visit (mean difference = 0.18, 95% CI: 0.14–0.21, P < 0.05). Laser irradiation inhibited the elevation of interleukin-1β, prostaglandin E2 and substance P levels during the first month (P < 0.05). However, no intergroup difference was detected in the bacteria levels. Low-level laser irradiation exhibits benefits in pain relief and inflammation control during the early stage of adjunctive orthodontic treatment in periodontally compromised individuals.-
dc.languageeng-
dc.publisherSpringer-Verlag London Ltd. The Journal's web site is located at http://link.springer-ny.com/link/service/journals/10103/index.htm-
dc.relation.ispartofLasers in Medical Science-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectLow-level laser irradiation-
dc.subjectOrthodontic-periodontal joint treatment-
dc.subjectRandomised clinical trial-
dc.subjectOrthodontic pain-
dc.subjectPeriodontal inflammation-
dc.titleLow-level laser-aided orthodontic treatment of periodontally compromised patients: a randomised controlled trial-
dc.typeArticle-
dc.identifier.emailMcGrath, C: mcgrathc@hkucc.hku.hk-
dc.identifier.emailGu, M: drgumin@hku.hk-
dc.identifier.emailJin, L: ljjin@hkucc.hku.hk-
dc.identifier.emailZhang, C: zhangcf@hku.hk-
dc.identifier.emailYang, Y: yangyanq@hku.hk-
dc.identifier.authorityMcGrath, C=rp00037-
dc.identifier.authorityGu, M=rp01892-
dc.identifier.authorityJin, L=rp00028-
dc.identifier.authorityZhang, C=rp01408-
dc.identifier.authorityChau, ACM=rp00044-
dc.identifier.authorityYang, Y=rp00045-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1007/s10103-019-02923-0-
dc.identifier.pmid31833004-
dc.identifier.scopuseid_2-s2.0-85076615872-
dc.identifier.hkuros313506-
dc.identifier.volume35-
dc.identifier.issue3-
dc.identifier.spage729-
dc.identifier.epage739-
dc.identifier.isiWOS:000519666700023-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0268-8921-

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