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Article: Guardian genes ensuring subsistence of oral Streptococcus mutans

TitleGuardian genes ensuring subsistence of oral Streptococcus mutans
Authors
KeywordsAcid tolerance
Biofilm
Competence
Dental caries
OMICS
Streptococcus mutans
Issue Date2020
PublisherTaylor & Francis. The Journal's web site is located at https://www.tandfonline.com/imby/
Citation
Critical Reviews in Microbiology, 2020, v. 46 n. 4, p. 475-491 How to Cite?
AbstractDespite the substantial research advancements on oral diseases, dental caries remains a major healthcare burden. A disease of microbial dysbiosis, dental caries is characterised by the formation of biofilms that assist demineralisation and destruction of the dental hard tissues. While it is well understood that this is a multi-kingdom biofilm-mediated disease, it has been elucidated that acid producing and acid tolerant bacteria play pioneering roles in the process. Specifically, Streptococcus mutans houses major virulence pathways that enable it to thrive in the oral cavity and cause caries. This pathogen adheres to the tooth substrate, forms biofilms, resists external stress, produces acids, kills closely related species, and survives the acid as well as the host clearance mechanisms. For an organism to be able to confer such virulence, it requires a large and complex gene network which synergise to establish disease. In this review, we have charted how these multi-faceted genes control several caries-related functions of Streptococcus mutans. In a futuristic thinking approach, we also briefly discuss the potential roles of omics and machine learning, to ease the study of non-functional genes that may play a major role and enable the integration of experimental data.
Persistent Identifierhttp://hdl.handle.net/10722/286141
ISSN
2023 Impact Factor: 6.0
2023 SCImago Journal Rankings: 1.675
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShanmugam, K-
dc.contributor.authorSarveswari, HB-
dc.contributor.authorUdayashankar, A-
dc.contributor.authorSwamy, SS-
dc.contributor.authorPudipeddi, A-
dc.contributor.authorShanmugam, T-
dc.contributor.authorSolomon, AP-
dc.contributor.authorNeelakantan, P-
dc.date.accessioned2020-08-31T06:59:42Z-
dc.date.available2020-08-31T06:59:42Z-
dc.date.issued2020-
dc.identifier.citationCritical Reviews in Microbiology, 2020, v. 46 n. 4, p. 475-491-
dc.identifier.issn1040-841X-
dc.identifier.urihttp://hdl.handle.net/10722/286141-
dc.description.abstractDespite the substantial research advancements on oral diseases, dental caries remains a major healthcare burden. A disease of microbial dysbiosis, dental caries is characterised by the formation of biofilms that assist demineralisation and destruction of the dental hard tissues. While it is well understood that this is a multi-kingdom biofilm-mediated disease, it has been elucidated that acid producing and acid tolerant bacteria play pioneering roles in the process. Specifically, Streptococcus mutans houses major virulence pathways that enable it to thrive in the oral cavity and cause caries. This pathogen adheres to the tooth substrate, forms biofilms, resists external stress, produces acids, kills closely related species, and survives the acid as well as the host clearance mechanisms. For an organism to be able to confer such virulence, it requires a large and complex gene network which synergise to establish disease. In this review, we have charted how these multi-faceted genes control several caries-related functions of Streptococcus mutans. In a futuristic thinking approach, we also briefly discuss the potential roles of omics and machine learning, to ease the study of non-functional genes that may play a major role and enable the integration of experimental data.-
dc.languageeng-
dc.publisherTaylor & Francis. The Journal's web site is located at https://www.tandfonline.com/imby/-
dc.relation.ispartofCritical Reviews in Microbiology-
dc.subjectAcid tolerance-
dc.subjectBiofilm-
dc.subjectCompetence-
dc.subjectDental caries-
dc.subjectOMICS-
dc.subjectStreptococcus mutans-
dc.titleGuardian genes ensuring subsistence of oral Streptococcus mutans-
dc.typeArticle-
dc.identifier.emailNeelakantan, P: prasanna@hku.hk-
dc.identifier.authorityNeelakantan, P=rp02214-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/1040841X.2020.1796579-
dc.identifier.pmid32720594-
dc.identifier.scopuseid_2-s2.0-85088815755-
dc.identifier.hkuros313138-
dc.identifier.volume46-
dc.identifier.issue4-
dc.identifier.spage475-
dc.identifier.epage491-
dc.identifier.isiWOS:000553325000001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1040-841X-

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