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Article: Short communication: HIV-1 gag genetic variation in a single acutely infected participant defined by high-resolution deep sequencing

TitleShort communication: HIV-1 gag genetic variation in a single acutely infected participant defined by high-resolution deep sequencing
Authors
Issue Date2014
Citation
AIDS Research and Human Retroviruses, 2014, v. 30, n. 8, p. 806-811 How to Cite?
AbstractAcute HIV-1 infection is characterized by the rapid generation of highly diverse genetic variants to adapt to the new host environment. Understanding the dynamics of viral genetic variation at this stage of infection is critical for vaccine design efforts and early drug treatment. Here, using a high-resolution deep sequencing approach targeting the HIV-1 gag region, we reveal very early immune pressure with dramatic subpopulation shifts in a single acutely infected participant providing further insight into the genetic dynamics of acute HIV-1 infection. © 2014, Mary Ann Liebert, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/285946
ISSN
2023 Impact Factor: 1.5
2023 SCImago Journal Rankings: 0.542
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAl-Mawsawi, Laith Q.-
dc.contributor.authorWu, Nicholas C.-
dc.contributor.authorDe La Cruz, Justin-
dc.contributor.authorShi, Vivian Cai-
dc.contributor.authorWu, Ting Ting-
dc.contributor.authorDaar, Eric S.-
dc.contributor.authorLewis, Martha J.-
dc.contributor.authorYang, Otto O.-
dc.contributor.authorSun, Ren-
dc.date.accessioned2020-08-18T04:57:03Z-
dc.date.available2020-08-18T04:57:03Z-
dc.date.issued2014-
dc.identifier.citationAIDS Research and Human Retroviruses, 2014, v. 30, n. 8, p. 806-811-
dc.identifier.issn0889-2229-
dc.identifier.urihttp://hdl.handle.net/10722/285946-
dc.description.abstractAcute HIV-1 infection is characterized by the rapid generation of highly diverse genetic variants to adapt to the new host environment. Understanding the dynamics of viral genetic variation at this stage of infection is critical for vaccine design efforts and early drug treatment. Here, using a high-resolution deep sequencing approach targeting the HIV-1 gag region, we reveal very early immune pressure with dramatic subpopulation shifts in a single acutely infected participant providing further insight into the genetic dynamics of acute HIV-1 infection. © 2014, Mary Ann Liebert, Inc.-
dc.languageeng-
dc.relation.ispartofAIDS Research and Human Retroviruses-
dc.titleShort communication: HIV-1 gag genetic variation in a single acutely infected participant defined by high-resolution deep sequencing-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1089/aid.2014.0097-
dc.identifier.pmid24914638-
dc.identifier.pmcidPMC4118717-
dc.identifier.scopuseid_2-s2.0-84905442673-
dc.identifier.volume30-
dc.identifier.issue8-
dc.identifier.spage806-
dc.identifier.epage811-
dc.identifier.eissn1931-8405-
dc.identifier.isiWOS:000340538900013-
dc.identifier.issnl0889-2229-

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