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Article: Single-round, multiplexed antibody mimetic design through mRNA display

TitleSingle-round, multiplexed antibody mimetic design through mRNA display
Authors
Olson, C. AndersNie, JeffDiep, JonathanAl-Shyoukh, IbrahimTakahashi, Terry T.Al-Mawsawi, Laith Q.Bolin, Jennifer M.Elwell, Angela L.Swanson, ScottStewart, RonThomson, James A.Soh, H. TomRoberts, Richard W.Sun, Ren
KeywordsmRNA display
ligand design
antibody mimetics
directed evolution
selection methods
Issue Date2012
Citation
Angewandte Chemie - International Edition, 2012, v. 51, n. 50, p. 12449-12453 How to Cite?
DOI: http://dx.doi.org/10.1002/anie.201207005
AbstractIn a single round: By combining the high-efficiency enrichment through the continuous-flow magnetic separation (CFMS) technique with the analytical power of next-generation sequencing, the generation of antibody mimetics with a single round of mRNA display is made possible. This approach eliminates iterative selection cycles and provides a path to fully automated ligand generation (see picture). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/285929
ISSN
1433-7851
2023 Impact Factor: 16.1
2023 SCImago Journal Rankings: 5.300
PubMed Central ID
PMC3832244
ISI Accession Number ID
WOS:000312213800008

 

DC FieldValueLanguage
dc.contributor.authorOlson, C. Anders-
dc.contributor.authorNie, Jeff-
dc.contributor.authorDiep, Jonathan-
dc.contributor.authorAl-Shyoukh, Ibrahim-
dc.contributor.authorTakahashi, Terry T.-
dc.contributor.authorAl-Mawsawi, Laith Q.-
dc.contributor.authorBolin, Jennifer M.-
dc.contributor.authorElwell, Angela L.-
dc.contributor.authorSwanson, Scott-
dc.contributor.authorStewart, Ron-
dc.contributor.authorThomson, James A.-
dc.contributor.authorSoh, H. Tom-
dc.contributor.authorRoberts, Richard W.-
dc.contributor.authorSun, Ren-
dc.date.accessioned2020-08-18T04:57:00Z-
dc.date.available2020-08-18T04:57:00Z-
dc.date.issued2012-
dc.identifier.citationAngewandte Chemie - International Edition, 2012, v. 51, n. 50, p. 12449-12453-
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/10722/285929-
dc.description.abstractIn a single round: By combining the high-efficiency enrichment through the continuous-flow magnetic separation (CFMS) technique with the analytical power of next-generation sequencing, the generation of antibody mimetics with a single round of mRNA display is made possible. This approach eliminates iterative selection cycles and provides a path to fully automated ligand generation (see picture). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.-
dc.languageeng-
dc.relation.ispartofAngewandte Chemie - International Edition-
dc.subjectmRNA display-
dc.subjectligand design-
dc.subjectantibody mimetics-
dc.subjectdirected evolution-
dc.subjectselection methods-
dc.titleSingle-round, multiplexed antibody mimetic design through mRNA display-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/anie.201207005-
dc.identifier.pmid23125174-
dc.identifier.pmcidPMC3832244-
dc.identifier.scopuseid_2-s2.0-84870621677-
dc.identifier.volume51-
dc.identifier.issue50-
dc.identifier.spage12449-
dc.identifier.epage12453-
dc.identifier.eissn1521-3773-
dc.identifier.isiWOS:000312213800008-
dc.identifier.issnl1433-7851-

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