File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model

Title25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model
Authors
Keywords25HC
antiviral immunity
CH25H
microcephaly
ZIKV
Issue Date2017
Citation
Immunity, 2017, v. 46, n. 3, p. 446-456 How to Cite?
Abstract© 2017 Zika virus (ZIKV) has become a public health threat due to its global transmission and link to severe congenital disorders. The host immune responses to ZIKV infection have not been fully elucidated, and effective therapeutics are not currently available. Herein, we demonstrated that cholesterol-25-hydroxylase (CH25H) was induced in response to ZIKV infection and that its enzymatic product, 25-hydroxycholesterol (25HC), was a critical mediator of host protection against ZIKV. Synthetic 25HC addition inhibited ZIKV infection in vitro by blocking viral entry, and treatment with 25HC reduced viremia and conferred protection against ZIKV in mice and rhesus macaques. 25HC suppressed ZIKV infection and reduced tissue damage in human cortical organoids and the embryonic brain of the ZIKV-induced mouse microcephaly model. Our findings highlight the protective role of CH25H during ZIKV infection and the potential use of 25HC as a natural antiviral agent to combat ZIKV infection and prevent ZIKV-associated outcomes, such as microcephaly.
Persistent Identifierhttp://hdl.handle.net/10722/285788
ISSN
2020 Impact Factor: 31.745
2020 SCImago Journal Rankings: 14.286
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Chunfeng-
dc.contributor.authorDeng, Yong Qiang-
dc.contributor.authorWang, Shuo-
dc.contributor.authorMa, Feng-
dc.contributor.authorAliyari, Roghiyh-
dc.contributor.authorHuang, Xing Yao-
dc.contributor.authorZhang, Na Na-
dc.contributor.authorWatanabe, Momoko-
dc.contributor.authorDong, Hao Long-
dc.contributor.authorLiu, Ping-
dc.contributor.authorLi, Xiao Feng-
dc.contributor.authorYe, Qing-
dc.contributor.authorTian, Min-
dc.contributor.authorHong, Shuai-
dc.contributor.authorFan, Junwan-
dc.contributor.authorZhao, Hui-
dc.contributor.authorLi, Lili-
dc.contributor.authorVishlaghi, Neda-
dc.contributor.authorButh, Jessie E.-
dc.contributor.authorAu, Connie-
dc.contributor.authorLiu, Ying-
dc.contributor.authorLu, Ning-
dc.contributor.authorDu, Peishuang-
dc.contributor.authorQin, F. Xiao Feng-
dc.contributor.authorZhang, Bo-
dc.contributor.authorGong, Danyang-
dc.contributor.authorDai, Xinghong-
dc.contributor.authorSun, Ren-
dc.contributor.authorNovitch, Bennett G.-
dc.contributor.authorXu, Zhiheng-
dc.contributor.authorQin, Cheng Feng-
dc.contributor.authorCheng, Genhong-
dc.date.accessioned2020-08-18T04:56:38Z-
dc.date.available2020-08-18T04:56:38Z-
dc.date.issued2017-
dc.identifier.citationImmunity, 2017, v. 46, n. 3, p. 446-456-
dc.identifier.issn1074-7613-
dc.identifier.urihttp://hdl.handle.net/10722/285788-
dc.description.abstract© 2017 Zika virus (ZIKV) has become a public health threat due to its global transmission and link to severe congenital disorders. The host immune responses to ZIKV infection have not been fully elucidated, and effective therapeutics are not currently available. Herein, we demonstrated that cholesterol-25-hydroxylase (CH25H) was induced in response to ZIKV infection and that its enzymatic product, 25-hydroxycholesterol (25HC), was a critical mediator of host protection against ZIKV. Synthetic 25HC addition inhibited ZIKV infection in vitro by blocking viral entry, and treatment with 25HC reduced viremia and conferred protection against ZIKV in mice and rhesus macaques. 25HC suppressed ZIKV infection and reduced tissue damage in human cortical organoids and the embryonic brain of the ZIKV-induced mouse microcephaly model. Our findings highlight the protective role of CH25H during ZIKV infection and the potential use of 25HC as a natural antiviral agent to combat ZIKV infection and prevent ZIKV-associated outcomes, such as microcephaly.-
dc.languageeng-
dc.relation.ispartofImmunity-
dc.subject25HC-
dc.subjectantiviral immunity-
dc.subjectCH25H-
dc.subjectmicrocephaly-
dc.subjectZIKV-
dc.title25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.immuni.2017.02.012-
dc.identifier.pmid28314593-
dc.identifier.pmcidPMC5957489-
dc.identifier.scopuseid_2-s2.0-85015784035-
dc.identifier.volume46-
dc.identifier.issue3-
dc.identifier.spage446-
dc.identifier.epage456-
dc.identifier.eissn1097-4180-
dc.identifier.isiWOS:000396818100016-
dc.identifier.f1000727423344-
dc.identifier.issnl1074-7613-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats