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Article: The ORF49 protein of murine gammaherpesvirus 68 cooperates with RTA in regulating virus replication

TitleThe ORF49 protein of murine gammaherpesvirus 68 cooperates with RTA in regulating virus replication
Authors
Lee, SangmiCho, Hye JeongPark, Jung JinKim, Yong SunHwang, SeungminSun, RenMoon, Jung Song
Issue Date2007
Citation
Journal of Virology, 2007, v. 81, n. 18, p. 9870-9877 How to Cite?
DOI: http://dx.doi.org/10.1128/JVI.00001-07
AbstractOur functional mapping study of murine gammaherpesvirus 68 (MHV-68, or γHV-68) revealed that a mutant harboring a transposon at the ORF49 locus (ORF49null) evidenced a highly attenuated in vitro growth. ORF49 resides adjacent to and in an opposite direction from RTA, the primary switch of the gammaherpesvirus life cycle. A FLAG-tagged ORF49 protein was able to transcomplement ORF49null, and a revertant of ORF49null restored its attenuated growth to a level comparable to that of the wild type. The FLAG-tagged ORF49 protein promoted the ability of RTA to activate downstream target promoters and enhanced virus replication from the ORF50null virus in the presence of RTA. Furthermore, ORF49 enhanced wild-type virus replication by increasing the RTA transcript levels. Our data indicate that ORF49 may perform an important function in MHV-68 replication in cooperation with RTA. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/285608
ISSN
0022-538X
2023 Impact Factor: 4.0
2023 SCImago Journal Rankings: 1.378
PubMed Central ID
PMC2045426
ISI Accession Number ID
WOS:000249315200024

 

DC FieldValueLanguage
dc.contributor.authorLee, Sangmi-
dc.contributor.authorCho, Hye Jeong-
dc.contributor.authorPark, Jung Jin-
dc.contributor.authorKim, Yong Sun-
dc.contributor.authorHwang, Seungmin-
dc.contributor.authorSun, Ren-
dc.contributor.authorMoon, Jung Song-
dc.date.accessioned2020-08-18T04:56:11Z-
dc.date.available2020-08-18T04:56:11Z-
dc.date.issued2007-
dc.identifier.citationJournal of Virology, 2007, v. 81, n. 18, p. 9870-9877-
dc.identifier.issn0022-538X-
dc.identifier.urihttp://hdl.handle.net/10722/285608-
dc.description.abstractOur functional mapping study of murine gammaherpesvirus 68 (MHV-68, or γHV-68) revealed that a mutant harboring a transposon at the ORF49 locus (ORF49null) evidenced a highly attenuated in vitro growth. ORF49 resides adjacent to and in an opposite direction from RTA, the primary switch of the gammaherpesvirus life cycle. A FLAG-tagged ORF49 protein was able to transcomplement ORF49null, and a revertant of ORF49null restored its attenuated growth to a level comparable to that of the wild type. The FLAG-tagged ORF49 protein promoted the ability of RTA to activate downstream target promoters and enhanced virus replication from the ORF50null virus in the presence of RTA. Furthermore, ORF49 enhanced wild-type virus replication by increasing the RTA transcript levels. Our data indicate that ORF49 may perform an important function in MHV-68 replication in cooperation with RTA. Copyright © 2007, American Society for Microbiology. All Rights Reserved.-
dc.languageeng-
dc.relation.ispartofJournal of Virology-
dc.titleThe ORF49 protein of murine gammaherpesvirus 68 cooperates with RTA in regulating virus replication-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/JVI.00001-07-
dc.identifier.pmid17634244-
dc.identifier.pmcidPMC2045426-
dc.identifier.scopuseid_2-s2.0-35348819393-
dc.identifier.volume81-
dc.identifier.issue18-
dc.identifier.spage9870-
dc.identifier.epage9877-
dc.identifier.isiWOS:000249315200024-
dc.identifier.issnl0022-538X-

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