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Article: B cell terminal differentiation factor XBP-1 induces reactivation of Kaposi's sarcoma-associated herpesvirus

TitleB cell terminal differentiation factor XBP-1 induces reactivation of Kaposi's sarcoma-associated herpesvirus
Authors
KeywordsKSHV
XBP-1
Reactivation
Issue Date2007
Citation
FEBS Letters, 2007, v. 581, n. 18, p. 3485-3488 How to Cite?
AbstractThe herpesvirus life cycle has two distinct phases: latency and lytic replication. The viral immediate early protein replication and transcription activator (RTA) plays a central role in mediating the balance between these two phases. Here, we demonstrate that a B cell terminal differentiation factor X-box binding protein 1 (XBP-1) can effectively initiates Kaposi's sarcoma-associated herpesvirus (KSHV) reactivation by activating the RTA promoter, which results in the induction of other viral lytic transcripts. We also showed splicing of the XBP-1 mRNA which specifically occurs during B cell differentiation is critical in triggering KSHV reactivation. This work demonstrates the integration of KSHV reactivation mechanisms with host cell differentiation. © 2007 Federation of European Biochemical Societies.
Persistent Identifierhttp://hdl.handle.net/10722/285603
ISSN
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 1.208
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYu, Fuqu-
dc.contributor.authorFeng, Jiaying-
dc.contributor.authorHarada, Josephine N.-
dc.contributor.authorChanda, Sumit K.-
dc.contributor.authorKenney, Shannon C.-
dc.contributor.authorSun, Ren-
dc.date.accessioned2020-08-18T04:56:10Z-
dc.date.available2020-08-18T04:56:10Z-
dc.date.issued2007-
dc.identifier.citationFEBS Letters, 2007, v. 581, n. 18, p. 3485-3488-
dc.identifier.issn0014-5793-
dc.identifier.urihttp://hdl.handle.net/10722/285603-
dc.description.abstractThe herpesvirus life cycle has two distinct phases: latency and lytic replication. The viral immediate early protein replication and transcription activator (RTA) plays a central role in mediating the balance between these two phases. Here, we demonstrate that a B cell terminal differentiation factor X-box binding protein 1 (XBP-1) can effectively initiates Kaposi's sarcoma-associated herpesvirus (KSHV) reactivation by activating the RTA promoter, which results in the induction of other viral lytic transcripts. We also showed splicing of the XBP-1 mRNA which specifically occurs during B cell differentiation is critical in triggering KSHV reactivation. This work demonstrates the integration of KSHV reactivation mechanisms with host cell differentiation. © 2007 Federation of European Biochemical Societies.-
dc.languageeng-
dc.relation.ispartofFEBS Letters-
dc.subjectKSHV-
dc.subjectXBP-1-
dc.subjectReactivation-
dc.titleB cell terminal differentiation factor XBP-1 induces reactivation of Kaposi's sarcoma-associated herpesvirus-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.febslet.2007.06.056-
dc.identifier.pmid17617410-
dc.identifier.scopuseid_2-s2.0-34447285052-
dc.identifier.volume581-
dc.identifier.issue18-
dc.identifier.spage3485-
dc.identifier.epage3488-
dc.identifier.isiWOS:000248473200027-
dc.identifier.issnl0014-5793-

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