File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.chom.2007.05.008
- Scopus: eid_2-s2.0-34249910944
- PMID: 18005708
- WOS: WOS:000250203300007
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: γ-Herpesvirus Kinase Actively Initiates a DNA Damage Response by Inducing Phosphorylation of H2AX to Foster Viral Replication
Title | γ-Herpesvirus Kinase Actively Initiates a DNA Damage Response by Inducing Phosphorylation of H2AX to Foster Viral Replication |
---|---|
Authors | |
Keywords | DNA MICROBIO |
Issue Date | 2007 |
Citation | Cell Host and Microbe, 2007, v. 1, n. 4, p. 275-286 How to Cite? |
Abstract | DNA virus infection can elicit the DNA damage response in host cells, including ATM kinase activation and H2AX phosphorylation. This is considered to be the host cell response to replicating viral DNA. In contrast, we show that during infection of macrophages murine γ-herpesvirus 68 (γHV68) actively induces H2AX phosphorylation by expressing a viral kinase (orf36). γHV68-encoded orf36 kinase and its EBV homolog, BGLF4, induce H2AX phosphorylation independently of other viral genes. The process requires the kinase domain of Orf36 and is enhanced by ATM. Orf36 is important for γHV68 replication in infected animals, and orf36, H2AX, and ATM are all critical for efficient γHV68 replication in primary macrophages. Thus, activation of proximal components of the DNA damage signaling response is an active viral kinase-driven strategy required for efficient γ-herpesvirus replication. © 2007 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/285601 |
ISSN | 2023 Impact Factor: 20.6 2023 SCImago Journal Rankings: 7.760 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tarakanova, Vera L. | - |
dc.contributor.author | Leung-Pineda, Van | - |
dc.contributor.author | Hwang, Seungmin | - |
dc.contributor.author | Yang, Chiao Wen | - |
dc.contributor.author | Matatall, Katie | - |
dc.contributor.author | Basson, Mickael | - |
dc.contributor.author | Sun, Ren | - |
dc.contributor.author | Piwnica-Worms, Helen | - |
dc.contributor.author | Sleckman, Barry P. | - |
dc.contributor.author | Virgin IV, Herbert W. | - |
dc.date.accessioned | 2020-08-18T04:56:10Z | - |
dc.date.available | 2020-08-18T04:56:10Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Cell Host and Microbe, 2007, v. 1, n. 4, p. 275-286 | - |
dc.identifier.issn | 1931-3128 | - |
dc.identifier.uri | http://hdl.handle.net/10722/285601 | - |
dc.description.abstract | DNA virus infection can elicit the DNA damage response in host cells, including ATM kinase activation and H2AX phosphorylation. This is considered to be the host cell response to replicating viral DNA. In contrast, we show that during infection of macrophages murine γ-herpesvirus 68 (γHV68) actively induces H2AX phosphorylation by expressing a viral kinase (orf36). γHV68-encoded orf36 kinase and its EBV homolog, BGLF4, induce H2AX phosphorylation independently of other viral genes. The process requires the kinase domain of Orf36 and is enhanced by ATM. Orf36 is important for γHV68 replication in infected animals, and orf36, H2AX, and ATM are all critical for efficient γHV68 replication in primary macrophages. Thus, activation of proximal components of the DNA damage signaling response is an active viral kinase-driven strategy required for efficient γ-herpesvirus replication. © 2007 Elsevier Inc. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Cell Host and Microbe | - |
dc.subject | DNA | - |
dc.subject | MICROBIO | - |
dc.title | γ-Herpesvirus Kinase Actively Initiates a DNA Damage Response by Inducing Phosphorylation of H2AX to Foster Viral Replication | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.chom.2007.05.008 | - |
dc.identifier.pmid | 18005708 | - |
dc.identifier.pmcid | PMC2034359 | - |
dc.identifier.scopus | eid_2-s2.0-34249910944 | - |
dc.identifier.volume | 1 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 275 | - |
dc.identifier.epage | 286 | - |
dc.identifier.isi | WOS:000250203300007 | - |
dc.identifier.issnl | 1931-3128 | - |