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Article: Identification of Proteins Associated with Murine Gammaherpesvirus 68 Virions

TitleIdentification of Proteins Associated with Murine Gammaherpesvirus 68 Virions
Authors
Issue Date2003
Citation
Journal of Virology, 2003, v. 77, n. 24, p. 13425-13432 How to Cite?
AbstractMurine gammaherpesvirus 68 (MHV68 [also known as γHV-68]) is distinguished by its ability to replicate to high titers in cultured cells, making it an excellent candidate for studying gammaherpesvirus virion composition. Extracellular MHV68 virions were isolated, and abundant virion-associated proteins were identified by mass spectrometry. Five nucleocapsid protein homologues, the tegument protein homologue encoded by open reading frame (ORF) 75c, and envelope glycoproteins B and H were detected. In addition, gene products from MHV68 ORF20, ORF24, ORF28, ORF45, ORF48, and ORF52 were identified in association with virions, suggesting that these gammaherpesvirus genes are involved in the early phase of infection or virion assembly and egress.
Persistent Identifierhttp://hdl.handle.net/10722/285582
ISSN
2023 Impact Factor: 4.0
2023 SCImago Journal Rankings: 1.378
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBortz, Eric-
dc.contributor.authorWhitelegge, Julian P.-
dc.contributor.authorJia, Qingmei-
dc.contributor.authorZhou, Z. Hong-
dc.contributor.authorStewart, James P.-
dc.contributor.authorWu, Ting Ting-
dc.contributor.authorSun, Ren-
dc.date.accessioned2020-08-18T04:56:07Z-
dc.date.available2020-08-18T04:56:07Z-
dc.date.issued2003-
dc.identifier.citationJournal of Virology, 2003, v. 77, n. 24, p. 13425-13432-
dc.identifier.issn0022-538X-
dc.identifier.urihttp://hdl.handle.net/10722/285582-
dc.description.abstractMurine gammaherpesvirus 68 (MHV68 [also known as γHV-68]) is distinguished by its ability to replicate to high titers in cultured cells, making it an excellent candidate for studying gammaherpesvirus virion composition. Extracellular MHV68 virions were isolated, and abundant virion-associated proteins were identified by mass spectrometry. Five nucleocapsid protein homologues, the tegument protein homologue encoded by open reading frame (ORF) 75c, and envelope glycoproteins B and H were detected. In addition, gene products from MHV68 ORF20, ORF24, ORF28, ORF45, ORF48, and ORF52 were identified in association with virions, suggesting that these gammaherpesvirus genes are involved in the early phase of infection or virion assembly and egress.-
dc.languageeng-
dc.relation.ispartofJournal of Virology-
dc.titleIdentification of Proteins Associated with Murine Gammaherpesvirus 68 Virions-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/JVI.77.24.13425-13432.2003-
dc.identifier.pmid14645600-
dc.identifier.pmcidPMC296060-
dc.identifier.scopuseid_2-s2.0-0344736795-
dc.identifier.volume77-
dc.identifier.issue24-
dc.identifier.spage13425-
dc.identifier.epage13432-
dc.identifier.isiWOS:000187025500052-
dc.identifier.issnl0022-538X-

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