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Article: Inhibition of gammaherpesvirus replication by RNA interference

TitleInhibition of gammaherpesvirus replication by RNA interference
Authors
Jia, QingmeiSun, Ren
Issue Date2003
Citation
Journal of Virology, 2003, v. 77, n. 5, p. 3301-3306 How to Cite?
DOI: http://dx.doi.org/10.1128/JVI.77.5.3301-3306.2003
AbstractRNA interference (RNAi) is a conserved mechanism in which double-stranded, small interfering RNAs (siRNAs) trigger a sequence-specific gene-silencing process. Here we describe the inhibition of murine herpesvirus 68 replication by siRNAs targeted to sequences encoding Rta, an immediate-early protein known as an initiator of the lytic viral gene expression program, and open reading frame 45 (ORF 45), a conserved viral protein. Our results suggest that RNAi can block gammaherpesvirus replication and ORF 45 is required for efficient viral production.
Persistent Identifierhttp://hdl.handle.net/10722/285574
ISSN
0022-538X
2023 Impact Factor: 4.0
2023 SCImago Journal Rankings: 1.378
PubMed Central ID
PMC149755
ISI Accession Number ID
WOS:000180999700052

 

DC FieldValueLanguage
dc.contributor.authorJia, Qingmei-
dc.contributor.authorSun, Ren-
dc.date.accessioned2020-08-18T04:56:06Z-
dc.date.available2020-08-18T04:56:06Z-
dc.date.issued2003-
dc.identifier.citationJournal of Virology, 2003, v. 77, n. 5, p. 3301-3306-
dc.identifier.issn0022-538X-
dc.identifier.urihttp://hdl.handle.net/10722/285574-
dc.description.abstractRNA interference (RNAi) is a conserved mechanism in which double-stranded, small interfering RNAs (siRNAs) trigger a sequence-specific gene-silencing process. Here we describe the inhibition of murine herpesvirus 68 replication by siRNAs targeted to sequences encoding Rta, an immediate-early protein known as an initiator of the lytic viral gene expression program, and open reading frame 45 (ORF 45), a conserved viral protein. Our results suggest that RNAi can block gammaherpesvirus replication and ORF 45 is required for efficient viral production.-
dc.languageeng-
dc.relation.ispartofJournal of Virology-
dc.titleInhibition of gammaherpesvirus replication by RNA interference-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/JVI.77.5.3301-3306.2003-
dc.identifier.pmid12584354-
dc.identifier.pmcidPMC149755-
dc.identifier.scopuseid_2-s2.0-0037372313-
dc.identifier.volume77-
dc.identifier.issue5-
dc.identifier.spage3301-
dc.identifier.epage3306-
dc.identifier.isiWOS:000180999700052-
dc.identifier.issnl0022-538X-

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