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Article: Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease

TitleCellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease
Authors
Issue Date1999
Citation
Journal of Virology, 1999, v. 73, n. 5, p. 4181-4187 How to Cite?
AbstractHuman herpesvirus 8 (HHV-8) infection has been implicated in the etiology of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD), three diseases that frequently develop in immunocompromised, human immunodeficiency virus-positive individuals. One hypothesis that would account for different pathological manifestations of infection by the same virus is that viral genes are differentially expressed in heterogeneous cell types. To test this hypothesis, we analyzed the localization and levels of expression of two viral genes expressed in latent and lytic infections and the viral homologue of interleukin-6 (vIL-6). We show that PEL parallels KS in the pattern of latent and lytic cycle viral gene expression but that the predominant infected cell type is a B cell. We also show that MCD differs from KS not only in the infected cell type (B-cell and T-cell lineage) but also in the pattern of viral gene expression. Only a few cells in the lesion are infected and all of these cells express lyric-cycle genes. Of possibly greater significance is the fact that in a comparison of KS, PEL, and MCD, we found dramatic differences in the levels of expression of vIL-6. Interleukin-6 is a B-cell growth and differentiation factor whose altered expression has been linked to plasma cell abnormalities, as well as myeloid and lymphoid malignancies. Our findings support the hypothesis that HHV-8 plays an important role in the pathogenesis of PEL and MCD, in which vIL-6 acts as an autocrine or paracrine factor in the lymphoproliferative processes common to both.
Persistent Identifierhttp://hdl.handle.net/10722/285566
ISSN
2020 Impact Factor: 5.103
2020 SCImago Journal Rankings: 2.617
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorStaskus, Katherine A.-
dc.contributor.authorSun, Ren-
dc.contributor.authorMiller, George-
dc.contributor.authorRacz, Paul-
dc.contributor.authorJaslowski, Anthony-
dc.contributor.authorMetroka, Craig-
dc.contributor.authorBrett-Smith, Helena-
dc.contributor.authorHaase, Ashley T.-
dc.date.accessioned2020-08-18T04:56:04Z-
dc.date.available2020-08-18T04:56:04Z-
dc.date.issued1999-
dc.identifier.citationJournal of Virology, 1999, v. 73, n. 5, p. 4181-4187-
dc.identifier.issn0022-538X-
dc.identifier.urihttp://hdl.handle.net/10722/285566-
dc.description.abstractHuman herpesvirus 8 (HHV-8) infection has been implicated in the etiology of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD), three diseases that frequently develop in immunocompromised, human immunodeficiency virus-positive individuals. One hypothesis that would account for different pathological manifestations of infection by the same virus is that viral genes are differentially expressed in heterogeneous cell types. To test this hypothesis, we analyzed the localization and levels of expression of two viral genes expressed in latent and lytic infections and the viral homologue of interleukin-6 (vIL-6). We show that PEL parallels KS in the pattern of latent and lytic cycle viral gene expression but that the predominant infected cell type is a B cell. We also show that MCD differs from KS not only in the infected cell type (B-cell and T-cell lineage) but also in the pattern of viral gene expression. Only a few cells in the lesion are infected and all of these cells express lyric-cycle genes. Of possibly greater significance is the fact that in a comparison of KS, PEL, and MCD, we found dramatic differences in the levels of expression of vIL-6. Interleukin-6 is a B-cell growth and differentiation factor whose altered expression has been linked to plasma cell abnormalities, as well as myeloid and lymphoid malignancies. Our findings support the hypothesis that HHV-8 plays an important role in the pathogenesis of PEL and MCD, in which vIL-6 acts as an autocrine or paracrine factor in the lymphoproliferative processes common to both.-
dc.languageeng-
dc.relation.ispartofJournal of Virology-
dc.titleCellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/jvi.73.5.4181-4187.1999-
dc.identifier.pmid10196314-
dc.identifier.pmcidPMC104197-
dc.identifier.scopuseid_2-s2.0-0032899921-
dc.identifier.volume73-
dc.identifier.issue5-
dc.identifier.spage4181-
dc.identifier.epage4187-
dc.identifier.isiWOS:000079701100076-
dc.identifier.issnl0022-538X-

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