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- Publisher Website: 10.1073/pnas.95.18.10866
- Scopus: eid_2-s2.0-0032167919
- PMID: 9724796
- WOS: WOS:000075730500094
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Article: A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus
Title | A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus |
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Authors | |
Issue Date | 1998 |
Citation | Proceedings of the National Academy of Sciences of the United States of America, 1998, v. 95, n. 18, p. 10866-10871 How to Cite? |
Abstract | Herpesviruses exist in two states, latency and a lytic productive cycle. Here we identify an immediate-early gene encoded by Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus eight (HHV8) that activates lytic cycle gene expression from the latent viral genome. The gene is a homologue of Rta, a transcriptional activator encoded by Epstein-Barr virus (EBV). KSHV/Rta activated KSHV early lytic genes, including virus-encoded interleukin 6 and polyadenylated nuclear RNA, and a late gene, small viral capsid antigen. In cells dually infected with Epstein-Barr virus and KSHV, each Rta activated only autologous lytic cycle genes. Expression of viral cytokines under control of the KSHV/Rta gene is likely to contribute to the pathogenesis of KSHV-associated diseases. |
Persistent Identifier | http://hdl.handle.net/10722/285562 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Sun, Ren | - |
dc.contributor.author | Lin, Su Fang | - |
dc.contributor.author | Gradoville, Lyndle | - |
dc.contributor.author | Yuan, Yan | - |
dc.contributor.author | Zhu, Fanxiu | - |
dc.contributor.author | Miller, George | - |
dc.date.accessioned | 2020-08-18T04:56:04Z | - |
dc.date.available | 2020-08-18T04:56:04Z | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, 1998, v. 95, n. 18, p. 10866-10871 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10722/285562 | - |
dc.description.abstract | Herpesviruses exist in two states, latency and a lytic productive cycle. Here we identify an immediate-early gene encoded by Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus eight (HHV8) that activates lytic cycle gene expression from the latent viral genome. The gene is a homologue of Rta, a transcriptional activator encoded by Epstein-Barr virus (EBV). KSHV/Rta activated KSHV early lytic genes, including virus-encoded interleukin 6 and polyadenylated nuclear RNA, and a late gene, small viral capsid antigen. In cells dually infected with Epstein-Barr virus and KSHV, each Rta activated only autologous lytic cycle genes. Expression of viral cytokines under control of the KSHV/Rta gene is likely to contribute to the pathogenesis of KSHV-associated diseases. | - |
dc.language | eng | - |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.title | A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1073/pnas.95.18.10866 | - |
dc.identifier.pmid | 9724796 | - |
dc.identifier.pmcid | PMC27987 | - |
dc.identifier.scopus | eid_2-s2.0-0032167919 | - |
dc.identifier.volume | 95 | - |
dc.identifier.issue | 18 | - |
dc.identifier.spage | 10866 | - |
dc.identifier.epage | 10871 | - |
dc.identifier.isi | WOS:000075730500094 | - |
dc.identifier.issnl | 0027-8424 | - |