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- Publisher Website: 10.1073/pnas.93.21.11883
- Scopus: eid_2-s2.0-0029966233
- PMID: 8876232
- WOS: WOS:A1996VM68100106
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Article: Polyadenylylated nuclear RNA encoded by Kaposi sarcoma-associated herpesvirus
Title | Polyadenylylated nuclear RNA encoded by Kaposi sarcoma-associated herpesvirus |
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Authors | |
Keywords | splicing snRNA Sm antigen mRNA polyadenylylation human herpesvirus 8 U1 RNA U RNA |
Issue Date | 1996 |
Citation | Proceedings of the National Academy of Sciences of the United States of America, 1996, v. 93, n. 21, p. 11883-11888 How to Cite? |
Abstract | A newly recognized γ herpesvirus known as Kaposi sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8) is present in Kaposi sarcomas and body-cavity-based lymphomas. Here we identify a novel abundant 1.2-kb RNA, polyadenylated nuclear RNA (PAN RNA), encoded by the virus. The majority of cDNAs produced from poly(A)-selected RNA isolated from a human body cavity lymphoma cell line 48 hr after butyrate induction of KSHV lytic replication represented PAN RNA. Within PAN RNA were two 9 and 16 nt stretches with 89% and 94% identity to U1 RNA. A third stretch of 14 nt was 93% complementary to U1. The 5' upstream region of PAN RNA contained both proximal and distal sequence elements characteristic of regulatory regions of U snRNAs, whereas the 3' end was polyadenylylated. PAN RNA was transcribed by RNA polymerase II, lacked a trimethylguanosine cap, and did not associate with polyribosomes. PAN RNA formed a speckled pattern in the nucleus typical of U snRNAs and colocalized with Sm protein. Therefore, PAN represents a new type of RNA, possessing features of both U snRNA and mRNA. |
Persistent Identifier | http://hdl.handle.net/10722/285556 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Sun, Ren | - |
dc.contributor.author | Lin, Su Fang | - |
dc.contributor.author | Gradoville, Lyn | - |
dc.contributor.author | Miller, George | - |
dc.date.accessioned | 2020-08-18T04:56:03Z | - |
dc.date.available | 2020-08-18T04:56:03Z | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, 1996, v. 93, n. 21, p. 11883-11888 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10722/285556 | - |
dc.description.abstract | A newly recognized γ herpesvirus known as Kaposi sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8) is present in Kaposi sarcomas and body-cavity-based lymphomas. Here we identify a novel abundant 1.2-kb RNA, polyadenylated nuclear RNA (PAN RNA), encoded by the virus. The majority of cDNAs produced from poly(A)-selected RNA isolated from a human body cavity lymphoma cell line 48 hr after butyrate induction of KSHV lytic replication represented PAN RNA. Within PAN RNA were two 9 and 16 nt stretches with 89% and 94% identity to U1 RNA. A third stretch of 14 nt was 93% complementary to U1. The 5' upstream region of PAN RNA contained both proximal and distal sequence elements characteristic of regulatory regions of U snRNAs, whereas the 3' end was polyadenylylated. PAN RNA was transcribed by RNA polymerase II, lacked a trimethylguanosine cap, and did not associate with polyribosomes. PAN RNA formed a speckled pattern in the nucleus typical of U snRNAs and colocalized with Sm protein. Therefore, PAN represents a new type of RNA, possessing features of both U snRNA and mRNA. | - |
dc.language | eng | - |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.subject | splicing | - |
dc.subject | snRNA | - |
dc.subject | Sm antigen | - |
dc.subject | mRNA | - |
dc.subject | polyadenylylation | - |
dc.subject | human herpesvirus 8 | - |
dc.subject | U1 RNA | - |
dc.subject | U RNA | - |
dc.title | Polyadenylylated nuclear RNA encoded by Kaposi sarcoma-associated herpesvirus | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1073/pnas.93.21.11883 | - |
dc.identifier.pmid | 8876232 | - |
dc.identifier.pmcid | PMC38153 | - |
dc.identifier.scopus | eid_2-s2.0-0029966233 | - |
dc.identifier.volume | 93 | - |
dc.identifier.issue | 21 | - |
dc.identifier.spage | 11883 | - |
dc.identifier.epage | 11888 | - |
dc.identifier.isi | WOS:A1996VM68100106 | - |
dc.identifier.issnl | 0027-8424 | - |