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- Publisher Website: 10.1109/EMBC.2019.8856300
- Scopus: eid_2-s2.0-85077857054
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Conference Paper: Investigation of the Optic Nerve Head Morphology Influence to the Optic Nerve Head Biomechanics – Population Specific Model
Title | Investigation of the Optic Nerve Head Morphology Influence to the Optic Nerve Head Biomechanics – Population Specific Model |
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Authors | |
Keywords | Morphology Stress Surface morphology Computational modeling Mathematical model |
Issue Date | 2019 |
Publisher | Institute of Electrical and Electronics Engineers. The Journal's web site is located at https://ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269 |
Citation | Proceedings of the 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Berlin, Germany, 23-27 July 2019, p. 5374-5377 How to Cite? |
Abstract | Glaucoma is an eye disorder potentially leading to permanent blindness through the damage of optic nerves at the optic nerve head (ONH). As a critical region of optic nerve damage, the porous Lamina Cribrosa (LC) in the ONH plays a critical role in determining whether optic nerves passing through will experience apoptosis in response to shear stress. The primary cause of shear stress to the LC is the increase in intraocular pressure (IOP). Since morphology governs how mechanical stresses distributes, LC morphology could be an important factor in determining the risks of glaucoma development and progression. The current project aims at investigating how anterior LC surface morphology impacts its response to shear stress caused by IOP. Results of the current study show that steeper LC morphologies could be associated with increased average shear stress on the anterior LC surface. The effect of LC morphology was comparable to that of IOP. This highlights the potential significance of LC morphology on the distribution of IOP-induced shear stress and calls for further investigation in this area. |
Persistent Identifier | http://hdl.handle.net/10722/285356 |
ISSN | 2020 SCImago Journal Rankings: 0.282 |
DC Field | Value | Language |
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dc.contributor.author | Ko, WLM | - |
dc.contributor.author | Lai, CCC | - |
dc.contributor.author | Ng, PCK | - |
dc.contributor.author | Chow, BHY | - |
dc.contributor.author | Woo, MJS | - |
dc.contributor.author | Yim, KHC | - |
dc.contributor.author | Kim, JR | - |
dc.date.accessioned | 2020-08-18T03:52:43Z | - |
dc.date.available | 2020-08-18T03:52:43Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Proceedings of the 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Berlin, Germany, 23-27 July 2019, p. 5374-5377 | - |
dc.identifier.issn | 1557-170X | - |
dc.identifier.uri | http://hdl.handle.net/10722/285356 | - |
dc.description.abstract | Glaucoma is an eye disorder potentially leading to permanent blindness through the damage of optic nerves at the optic nerve head (ONH). As a critical region of optic nerve damage, the porous Lamina Cribrosa (LC) in the ONH plays a critical role in determining whether optic nerves passing through will experience apoptosis in response to shear stress. The primary cause of shear stress to the LC is the increase in intraocular pressure (IOP). Since morphology governs how mechanical stresses distributes, LC morphology could be an important factor in determining the risks of glaucoma development and progression. The current project aims at investigating how anterior LC surface morphology impacts its response to shear stress caused by IOP. Results of the current study show that steeper LC morphologies could be associated with increased average shear stress on the anterior LC surface. The effect of LC morphology was comparable to that of IOP. This highlights the potential significance of LC morphology on the distribution of IOP-induced shear stress and calls for further investigation in this area. | - |
dc.language | eng | - |
dc.publisher | Institute of Electrical and Electronics Engineers. The Journal's web site is located at https://ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269 | - |
dc.relation.ispartof | IEEE Engineering in Medicine and Biology Society (EMBC) Conference Proceedings | - |
dc.rights | IEEE Engineering in Medicine and Biology Society (EMBC) Conference Proceedings. Copyright © Institute of Electrical and Electronics Engineers. | - |
dc.rights | ©2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. | - |
dc.subject | Morphology | - |
dc.subject | Stress | - |
dc.subject | Surface morphology | - |
dc.subject | Computational modeling | - |
dc.subject | Mathematical model | - |
dc.title | Investigation of the Optic Nerve Head Morphology Influence to the Optic Nerve Head Biomechanics – Population Specific Model | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Ko, WLM: matchko@hku.hk | - |
dc.identifier.doi | 10.1109/EMBC.2019.8856300 | - |
dc.identifier.scopus | eid_2-s2.0-85077857054 | - |
dc.identifier.hkuros | 312858 | - |
dc.identifier.spage | 5374 | - |
dc.identifier.epage | 5377 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1557-170X | - |