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Article: Is the treatment outcome of hepatocellular carcinoma inferior in elderly patients?

TitleIs the treatment outcome of hepatocellular carcinoma inferior in elderly patients?
Authors
KeywordsHepatocellular carcinoma
Aged
Clinical outcome
Surgery
Hepatectomy
Issue Date2019
PublisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
Citation
World Journal of Gastroenterology, 2019, v. 25 n. 27, p. 3563-3571 How to Cite?
AbstractIn view of the increasing life expectancy in different parts of the world, a larger proportion of elderly patients with hepatocellular carcinoma (HCC) requiring oncological treatment is expected. The clinicopathological characteristics of HCC in elderly patients and in younger patients are different. Elderly patients, in general, also have more comorbidities. Evaluation of the efficacy of different HCC treatment options in elderly patients is necessary to optimize treatment outcomes for them. Treatment modalities for HCC include hepatectomy, liver transplantation, radiofrequency ablation, transarterial chemoembolization, and molecular-targeted therapy with sorafenib. In this review, current evidence on the risks and outcomes of the different HCC treatments for elderly patients are discussed. According to data in the literature, elderly patients and younger patients benefited similarly from HCC treatments. More clinical data are needed for the determination of selecting criteria on elderly HCC patients to maximize their chance of getting the most appropriate and effective treatments. As such, further studies evaluating the outcomes of different HCC treatment modalities in elderly patients are warranted.
Persistent Identifierhttp://hdl.handle.net/10722/285318
ISSN
2020 Impact Factor: 5.742
2015 SCImago Journal Rankings: 1.076
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChu, KWK-
dc.contributor.authorChok, KSH-
dc.date.accessioned2020-08-18T03:52:22Z-
dc.date.available2020-08-18T03:52:22Z-
dc.date.issued2019-
dc.identifier.citationWorld Journal of Gastroenterology, 2019, v. 25 n. 27, p. 3563-3571-
dc.identifier.issn1007-9327-
dc.identifier.urihttp://hdl.handle.net/10722/285318-
dc.description.abstractIn view of the increasing life expectancy in different parts of the world, a larger proportion of elderly patients with hepatocellular carcinoma (HCC) requiring oncological treatment is expected. The clinicopathological characteristics of HCC in elderly patients and in younger patients are different. Elderly patients, in general, also have more comorbidities. Evaluation of the efficacy of different HCC treatment options in elderly patients is necessary to optimize treatment outcomes for them. Treatment modalities for HCC include hepatectomy, liver transplantation, radiofrequency ablation, transarterial chemoembolization, and molecular-targeted therapy with sorafenib. In this review, current evidence on the risks and outcomes of the different HCC treatments for elderly patients are discussed. According to data in the literature, elderly patients and younger patients benefited similarly from HCC treatments. More clinical data are needed for the determination of selecting criteria on elderly HCC patients to maximize their chance of getting the most appropriate and effective treatments. As such, further studies evaluating the outcomes of different HCC treatment modalities in elderly patients are warranted.-
dc.languageeng-
dc.publisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm-
dc.relation.ispartofWorld Journal of Gastroenterology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectHepatocellular carcinoma-
dc.subjectAged-
dc.subjectClinical outcome-
dc.subjectSurgery-
dc.subjectHepatectomy-
dc.titleIs the treatment outcome of hepatocellular carcinoma inferior in elderly patients?-
dc.typeArticle-
dc.identifier.emailChok, KSH: chok6275@hku.hk-
dc.identifier.authorityChok, KSH=rp02110-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3748/wjg.v25.i27.3563-
dc.identifier.pmid31367157-
dc.identifier.pmcidPMC6658391-
dc.identifier.scopuseid_2-s2.0-85069976489-
dc.identifier.hkuros312948-
dc.identifier.volume25-
dc.identifier.issue27-
dc.identifier.spage3563-
dc.identifier.epage3571-
dc.identifier.isiWOS:000476473600007-
dc.publisher.placeUnited States-
dc.identifier.issnl1007-9327-

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