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Article: Vascular resection and reconstruction in hilar cholangiocarcinoma

TitleVascular resection and reconstruction in hilar cholangiocarcinoma
Authors
Keywordshepatectomy
hepatopancreaticobiliary surgery
hilar cholangiocarcinoma
vascular reconstruction
vascular resection
Issue Date2020
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ANS
Citation
ANZ Journal of Surgery, 2020, v. 90 n. 9, p. 1653-1659 How to Cite?
AbstractBackground: The aggressive approach of vascular resection plus reconstruction in curative resection of hilar cholangiocarcinoma (HC) remains controversial. This retrospective study investigated its short‐ and long‐term outcomes. Methods: Data of HC patients from 1989 to 2016 were reviewed. Operated patients were divided into two groups (with and without vascular resection) and compared in terms of perioperative results. Patients who had unresectable HC were also compared with patients who had been operated. Results: Ninety patients underwent curative HC resection. They were divided into group A (without aggressive approach, n = 68) and group B (with aggressive approach, n = 22). The groups were comparable in all parameters including rates of overall and major complication and in‐hospital, 30‐day and 90‐day mortality except that group B had more patients with more advanced disease (P = 0.008), more patients with tumour invasion of the vasculature (40.9% versus 7.4%, P = 0.001), and fewer patients with blood transfusion (27.3% versus 52.9%, P = 0.036). The groups had similar disease‐free survival (group A: median, 17.9 months, 5 years, 27.4%; group B: median, 11.7 months, 5 years, 14.3%; P = 0.427) and overall survival (group A: median, 22.0 months, 5 years, 26.5%; group B: median, 26.5 months, 5 years, 14.7%; P = 0.90). Two hundred patients with unresectable HC were compared with patients who had received operation and found to have worse survival outcomes (P < 0.001). Conclusions: Vascular resection plus reconstruction in HC resection was feasible and safe and might improve the long‐term survival of patients with advanced HC. This aggressive approach should be adopted if the expertise is available and the patient's condition allows.
Persistent Identifierhttp://hdl.handle.net/10722/285315
ISSN
2023 Impact Factor: 1.5
2023 SCImago Journal Rankings: 0.453
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShe, WH-
dc.contributor.authorCheung, TT-
dc.contributor.authorMa, KW-
dc.contributor.authorTsang, SHY-
dc.contributor.authorDai, WC-
dc.contributor.authorChan, ACY-
dc.contributor.authorLo, CM-
dc.date.accessioned2020-08-18T03:52:20Z-
dc.date.available2020-08-18T03:52:20Z-
dc.date.issued2020-
dc.identifier.citationANZ Journal of Surgery, 2020, v. 90 n. 9, p. 1653-1659-
dc.identifier.issn1445-1433-
dc.identifier.urihttp://hdl.handle.net/10722/285315-
dc.description.abstractBackground: The aggressive approach of vascular resection plus reconstruction in curative resection of hilar cholangiocarcinoma (HC) remains controversial. This retrospective study investigated its short‐ and long‐term outcomes. Methods: Data of HC patients from 1989 to 2016 were reviewed. Operated patients were divided into two groups (with and without vascular resection) and compared in terms of perioperative results. Patients who had unresectable HC were also compared with patients who had been operated. Results: Ninety patients underwent curative HC resection. They were divided into group A (without aggressive approach, n = 68) and group B (with aggressive approach, n = 22). The groups were comparable in all parameters including rates of overall and major complication and in‐hospital, 30‐day and 90‐day mortality except that group B had more patients with more advanced disease (P = 0.008), more patients with tumour invasion of the vasculature (40.9% versus 7.4%, P = 0.001), and fewer patients with blood transfusion (27.3% versus 52.9%, P = 0.036). The groups had similar disease‐free survival (group A: median, 17.9 months, 5 years, 27.4%; group B: median, 11.7 months, 5 years, 14.3%; P = 0.427) and overall survival (group A: median, 22.0 months, 5 years, 26.5%; group B: median, 26.5 months, 5 years, 14.7%; P = 0.90). Two hundred patients with unresectable HC were compared with patients who had received operation and found to have worse survival outcomes (P < 0.001). Conclusions: Vascular resection plus reconstruction in HC resection was feasible and safe and might improve the long‐term survival of patients with advanced HC. This aggressive approach should be adopted if the expertise is available and the patient's condition allows.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ANS-
dc.relation.ispartofANZ Journal of Surgery-
dc.subjecthepatectomy-
dc.subjecthepatopancreaticobiliary surgery-
dc.subjecthilar cholangiocarcinoma-
dc.subjectvascular reconstruction-
dc.subjectvascular resection-
dc.titleVascular resection and reconstruction in hilar cholangiocarcinoma-
dc.typeArticle-
dc.identifier.emailShe, WH: brianshe@hku.hk-
dc.identifier.emailCheung, TT: cheung68@hku.hk-
dc.identifier.emailDai, WC: daiwc@hku.hk-
dc.identifier.emailChan, ACY: acchan@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.authorityCheung, TT=rp02129-
dc.identifier.authorityChan, ACY=rp00310-
dc.identifier.authorityLo, CM=rp00412-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/ans.15969-
dc.identifier.pmid32458528-
dc.identifier.scopuseid_2-s2.0-85085491700-
dc.identifier.hkuros312941-
dc.identifier.volume90-
dc.identifier.issue9-
dc.identifier.spage1653-
dc.identifier.epage1659-
dc.identifier.isiWOS:000535372400001-
dc.publisher.placeAustralia-
dc.identifier.issnl1445-1433-

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