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Article: Discovering the Potentials of Medicinal Mushrooms in Combating Depression – A Review

TitleDiscovering the Potentials of Medicinal Mushrooms in Combating Depression – A Review
Authors
KeywordsDepression
pathophysiology
synthetic drug
traditional medicine
medicinal mushroom
Issue Date2020
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/mrmc/index.htm
Citation
Mini-Reviews in Medicinal Chemistry, 2020, v. 20 n. 15, p. 1518-1531 How to Cite?
AbstractDepression is the most common form of mental illness and the major cause of disability worldwide. Symptoms of depression, including feelings of intense sadness and hopelessness, may occur after a specific event or in response to a gradual decline in health and functional status, often associated with aging. Current therapies for treating these symptoms include antidepressant drugs, counseling and behavioral therapy. However, antidepressant drugs are associated with mild to severe adverse effects, which has prompted the need for better treatment options. Medicinal mushrooms are valuable sources of food and medicine and are increasingly being used as supplements or as alternative medicines in standard healthcare. Numerous studies have provided insights into the neuroprotective effects of medicinal mushrooms, which are attributed to their antioxidant, anti-neuroinflammatory, cholinesterase inhibitory and neuroprotective properties. In this review, we comprehensively examine the role of these medicinal mushrooms in the treatment of depression. However, to apply these natural products in clinical settings, the therapeutic agent needs to be properly evaluated, including the active ingredients, the presence of synergistic effects, efficient extraction methods, and stabilization of the active ingredients for delivery into the body as well as crossing the blood-brain barrier.
Persistent Identifierhttp://hdl.handle.net/10722/285054
ISSN
2023 Impact Factor: 3.3
2023 SCImago Journal Rankings: 0.597
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLew, SY-
dc.contributor.authorTeoh, SL-
dc.contributor.authorLim, SH-
dc.contributor.authorLim, LW-
dc.contributor.authorWong, KH-
dc.date.accessioned2020-08-07T09:06:07Z-
dc.date.available2020-08-07T09:06:07Z-
dc.date.issued2020-
dc.identifier.citationMini-Reviews in Medicinal Chemistry, 2020, v. 20 n. 15, p. 1518-1531-
dc.identifier.issn1389-5575-
dc.identifier.urihttp://hdl.handle.net/10722/285054-
dc.description.abstractDepression is the most common form of mental illness and the major cause of disability worldwide. Symptoms of depression, including feelings of intense sadness and hopelessness, may occur after a specific event or in response to a gradual decline in health and functional status, often associated with aging. Current therapies for treating these symptoms include antidepressant drugs, counseling and behavioral therapy. However, antidepressant drugs are associated with mild to severe adverse effects, which has prompted the need for better treatment options. Medicinal mushrooms are valuable sources of food and medicine and are increasingly being used as supplements or as alternative medicines in standard healthcare. Numerous studies have provided insights into the neuroprotective effects of medicinal mushrooms, which are attributed to their antioxidant, anti-neuroinflammatory, cholinesterase inhibitory and neuroprotective properties. In this review, we comprehensively examine the role of these medicinal mushrooms in the treatment of depression. However, to apply these natural products in clinical settings, the therapeutic agent needs to be properly evaluated, including the active ingredients, the presence of synergistic effects, efficient extraction methods, and stabilization of the active ingredients for delivery into the body as well as crossing the blood-brain barrier.-
dc.languageeng-
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/mrmc/index.htm-
dc.relation.ispartofMini-Reviews in Medicinal Chemistry-
dc.subjectDepression-
dc.subjectpathophysiology-
dc.subjectsynthetic drug-
dc.subjecttraditional medicine-
dc.subjectmedicinal mushroom-
dc.titleDiscovering the Potentials of Medicinal Mushrooms in Combating Depression – A Review-
dc.typeArticle-
dc.identifier.emailLim, LW: limlw@hku.hk-
dc.identifier.authorityLim, LW=rp02088-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/1389557520666200526125534-
dc.identifier.scopuseid_2-s2.0-85090607124-
dc.identifier.hkuros311511-
dc.identifier.volume20-
dc.identifier.issue15-
dc.identifier.spage1518-
dc.identifier.epage1531-
dc.identifier.isiWOS:000581711100005-
dc.publisher.placeNetherlands-
dc.identifier.issnl1389-5575-

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