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Article: A minimal mechanosensing model predicts keratocyte evolution on flexible substrates

TitleA minimal mechanosensing model predicts keratocyte evolution on flexible substrates
Authors
Keywordscellular locomotion
mechanosensing
keratocytes
level set method
Issue Date2020
PublisherThe Royal Society. The Journal's web site is located at http://publishing.royalsociety.org/index.cfm?page=1572
Citation
Journal of the Royal Society Interface, 2020, v. 17 n. 166, p. article no. 20200175 How to Cite?
AbstractA mathematical model is proposed for shape evolution and locomotion of fish epidermal keratocytes on elastic substrates. The model is based on mechanosensing concepts: cells apply contractile forces onto the elastic substrate, while cell shape evolution depends locally on the substrate stress generated by themselves or external mechanical stimuli acting on the substrate. We use the level set method to study the behaviour of the model numerically, and predict a number of distinct phenomena observed in experiments, such as (i) symmetry breaking from the stationary centrosymmetric to the well-known steadily propagating crescent shape, (ii) asymmetric bipedal oscillations and travelling waves in the lamellipodium leading edge, (iii) response to remote mechanical stress externally applied to the substrate (tensotaxis) and (iv) changing direction of motion towards an interface with a rigid substrate (durotaxis).
Persistent Identifierhttp://hdl.handle.net/10722/284979
ISSN
2023 Impact Factor: 3.7
2023 SCImago Journal Rankings: 1.101
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Z-
dc.contributor.authorRosakis, P-
dc.contributor.authorHou, T-
dc.contributor.authorRavichandran, G-
dc.date.accessioned2020-08-07T09:05:08Z-
dc.date.available2020-08-07T09:05:08Z-
dc.date.issued2020-
dc.identifier.citationJournal of the Royal Society Interface, 2020, v. 17 n. 166, p. article no. 20200175-
dc.identifier.issn1742-5689-
dc.identifier.urihttp://hdl.handle.net/10722/284979-
dc.description.abstractA mathematical model is proposed for shape evolution and locomotion of fish epidermal keratocytes on elastic substrates. The model is based on mechanosensing concepts: cells apply contractile forces onto the elastic substrate, while cell shape evolution depends locally on the substrate stress generated by themselves or external mechanical stimuli acting on the substrate. We use the level set method to study the behaviour of the model numerically, and predict a number of distinct phenomena observed in experiments, such as (i) symmetry breaking from the stationary centrosymmetric to the well-known steadily propagating crescent shape, (ii) asymmetric bipedal oscillations and travelling waves in the lamellipodium leading edge, (iii) response to remote mechanical stress externally applied to the substrate (tensotaxis) and (iv) changing direction of motion towards an interface with a rigid substrate (durotaxis).-
dc.languageeng-
dc.publisherThe Royal Society. The Journal's web site is located at http://publishing.royalsociety.org/index.cfm?page=1572-
dc.relation.ispartofJournal of the Royal Society Interface-
dc.subjectcellular locomotion-
dc.subjectmechanosensing-
dc.subjectkeratocytes-
dc.subjectlevel set method-
dc.titleA minimal mechanosensing model predicts keratocyte evolution on flexible substrates-
dc.typeArticle-
dc.identifier.emailZhang, Z: zhangzw@hku.hk-
dc.identifier.authorityZhang, Z=rp02087-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1098/rsif.2020.0175-
dc.identifier.pmid32370690-
dc.identifier.pmcidPMC7276546-
dc.identifier.scopuseid_2-s2.0-85084328737-
dc.identifier.hkuros311585-
dc.identifier.volume17-
dc.identifier.issue166-
dc.identifier.spagearticle no. 20200175-
dc.identifier.epagearticle no. 20200175-
dc.identifier.isiWOS:000532489600005-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1742-5662-

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