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Article: New insights on brain-derived neurotrophic factor epigenetics: from depression to memory extinction

TitleNew insights on brain-derived neurotrophic factor epigenetics: from depression to memory extinction
Authors
Keywordsdepression
brain‐derived neurotrophic factor
DNA methylation
histone modification
memory extinction
Issue Date2020
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1
Citation
Annals of the New York Academy of Sciences, 2020, Epub 2020-08-17 How to Cite?
AbstractAdvances in characterizing molecular profiles provide valuable insights and opportunities for deciphering the neuropathology of depression. Although abnormal brain-derived neurotrophic factor (BDNF) expression in depression has gained much support from preclinical and clinical research, how it mediates behavioral alterations in the depressed state remains largely obscure. Environmental factors contribute significantly to the onset of depression and produce robust epigenetic changes. Epigenetic regulation of BDNF, as one of the most characterized gene loci in epigenetics, has recently emerged as a target in research on memory and psychiatric disorders. Specifically, epigenetic alterations of BDNF exons are heavily involved in mediating memory functions and antidepressant effects. In this review, we discuss key research on stress-induced depression from both preclinical and clinical studies, which revealed that differential epigenetic regulation of specific BDNF exons was associated with depression pathophysiology. Considering that BDNF has a central role in depression, we argue that memory extinction, an adaptive response to fear exposure, is dependent on BDNF modulation and holds promise as a prospective target for alleviating or treating depression and anxiety disorders.
Persistent Identifierhttp://hdl.handle.net/10722/284779
ISSN
2019 Impact Factor: 4.728
2015 SCImago Journal Rankings: 2.389
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPOON, CH-
dc.contributor.authorHeng, BC-
dc.contributor.authorLim, LW-
dc.date.accessioned2020-08-07T09:02:31Z-
dc.date.available2020-08-07T09:02:31Z-
dc.date.issued2020-
dc.identifier.citationAnnals of the New York Academy of Sciences, 2020, Epub 2020-08-17-
dc.identifier.issn0077-8923-
dc.identifier.urihttp://hdl.handle.net/10722/284779-
dc.description.abstractAdvances in characterizing molecular profiles provide valuable insights and opportunities for deciphering the neuropathology of depression. Although abnormal brain-derived neurotrophic factor (BDNF) expression in depression has gained much support from preclinical and clinical research, how it mediates behavioral alterations in the depressed state remains largely obscure. Environmental factors contribute significantly to the onset of depression and produce robust epigenetic changes. Epigenetic regulation of BDNF, as one of the most characterized gene loci in epigenetics, has recently emerged as a target in research on memory and psychiatric disorders. Specifically, epigenetic alterations of BDNF exons are heavily involved in mediating memory functions and antidepressant effects. In this review, we discuss key research on stress-induced depression from both preclinical and clinical studies, which revealed that differential epigenetic regulation of specific BDNF exons was associated with depression pathophysiology. Considering that BDNF has a central role in depression, we argue that memory extinction, an adaptive response to fear exposure, is dependent on BDNF modulation and holds promise as a prospective target for alleviating or treating depression and anxiety disorders.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1-
dc.relation.ispartofAnnals of the New York Academy of Sciences-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectdepression-
dc.subjectbrain‐derived neurotrophic factor-
dc.subjectDNA methylation-
dc.subjecthistone modification-
dc.subjectmemory extinction-
dc.titleNew insights on brain-derived neurotrophic factor epigenetics: from depression to memory extinction-
dc.typeArticle-
dc.identifier.emailLim, LW: limlw@hku.hk-
dc.identifier.authorityLim, LW=rp02088-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/nyas.14458-
dc.identifier.pmid32808327-
dc.identifier.hkuros311494-
dc.identifier.volumeEpub 2020-08-17-
dc.identifier.isiWOS:000559914300001-
dc.publisher.placeUnited States-

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