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Article: Interaction of Polyphenols as Antioxidant and Anti-Inflammatory Compounds in Brain–Liver–Gut Axis

TitleInteraction of Polyphenols as Antioxidant and Anti-Inflammatory Compounds in Brain–Liver–Gut Axis
Authors
Keywordsoxidative stress
inflammation
polyphenols
antioxidant
Issue Date2020
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/antioxidants
Citation
Antioxidants, 2020, v. 9, p. article no. 669 How to Cite?
AbstractOxidative stress plays an important role in the onset as well as the progression of inflammation. Without proper intervention, acute inflammation could progress to chronic inflammation, resulting in the development of inflammatory diseases. Antioxidants, such as polyphenols, have been known to possess anti-oxidative properties which promote redox homeostasis. This has encouraged research on polyphenols as potential therapeutics for inflammation through anti-oxidative and anti-inflammatory pathways. In this review, the ability of polyphenols to modulate the activation of major pathways of inflammation and oxidative stress, and their potential to regulate the activity of immune cells are examined. In addition, in this review, special emphasis has been placed on the effects of polyphenols on inflammation in the brain–liver–gut axis. The data derived from in vitro cell studies, animal models and human intervention studies are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/284706
ISSN

 

DC FieldValueLanguage
dc.contributor.authorSingh, A-
dc.contributor.authorYAU, YF-
dc.contributor.authorLeung, KS-
dc.contributor.authorEl-Nezamy, HS-
dc.contributor.authorLee, JCY-
dc.date.accessioned2020-08-07T09:01:34Z-
dc.date.available2020-08-07T09:01:34Z-
dc.date.issued2020-
dc.identifier.citationAntioxidants, 2020, v. 9, p. article no. 669-
dc.identifier.issn2076-3921-
dc.identifier.urihttp://hdl.handle.net/10722/284706-
dc.description.abstractOxidative stress plays an important role in the onset as well as the progression of inflammation. Without proper intervention, acute inflammation could progress to chronic inflammation, resulting in the development of inflammatory diseases. Antioxidants, such as polyphenols, have been known to possess anti-oxidative properties which promote redox homeostasis. This has encouraged research on polyphenols as potential therapeutics for inflammation through anti-oxidative and anti-inflammatory pathways. In this review, the ability of polyphenols to modulate the activation of major pathways of inflammation and oxidative stress, and their potential to regulate the activity of immune cells are examined. In addition, in this review, special emphasis has been placed on the effects of polyphenols on inflammation in the brain–liver–gut axis. The data derived from in vitro cell studies, animal models and human intervention studies are discussed.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/antioxidants-
dc.relation.ispartofAntioxidants-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectoxidative stress-
dc.subjectinflammation-
dc.subjectpolyphenols-
dc.subjectantioxidant-
dc.titleInteraction of Polyphenols as Antioxidant and Anti-Inflammatory Compounds in Brain–Liver–Gut Axis-
dc.typeArticle-
dc.identifier.emailLeung, KS: lks612@hku.hk-
dc.identifier.emailEl-Nezamy, HS: elnezami@hkucc.hku.hk-
dc.identifier.emailLee, JCY: jettylee@hku.hk-
dc.identifier.authorityEl-Nezamy, HS=rp00694-
dc.identifier.authorityLee, JCY=rp01511-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/antiox9080669-
dc.identifier.scopuseid_2-s2.0-85090691918-
dc.identifier.hkuros311978-
dc.identifier.volume9-
dc.identifier.spagearticle no. 669-
dc.identifier.epagearticle no. 669-
dc.publisher.placeSwitzerland-

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