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Article: Trends in oral anticoagulant prescribing in individuals with type 2 diabetes mellitus: a population-based study in the UK

TitleTrends in oral anticoagulant prescribing in individuals with type 2 diabetes mellitus: a population-based study in the UK
Authors
Keywordsage
aged
atrial fibrillation
cohort analysis
controlled study
Issue Date2020
PublisherBMJ Publishing Group: BMJ Open. The Journal's web site is located at http://bmjopen.bmj.com
Citation
BMJ Open, 2020, v. 10 n. 5, p. article no. e034573 How to Cite?
AbstractObjective: To evaluate oral anticoagulant (OAC) prescribing trends in type 2 diabetes mellitus (T2DM) in the UK from 2001 to 2015. Design: A cross-sectional drug utilisation study. Setting: Electronic health records from The Health Improvement Network primary care database in the UK. Participants: Individuals with T2DM who received a record of OAC prescription. Outcome measures: The prescribing trends of OAC medications in individuals with T2DM were examined from 2001 to 2015, stratified by age, gender and therapeutic classifications. Results A total of 361 635 individuals with T2DM were identified, of whom 36 570 were prescribed OAC from 2001 to 2015. The prevalence of OAC prescribing increased by 50.0%, from 1781 individuals receiving OAC prescriptions (IROACP) (4.4 (95% CI 4.2 to 4.6) per 100 persons) in 2001, to 17 070 IROACP (6.6 (95% CI 6.5 to 6.7) per 100 persons) in 2015. The prevalence of warfarin prescribing decreased by 14.0%, from 1761 individuals receiving warfarin prescriptions (IRWP) (98.9 (95% CI 98.4 to 99.4) per 100 persons) in 2001, to 14 533 IRWP (85.1 (95% CI 84.6 to 85.7) per 100 persons) in 2015. This corresponded with increased prescribing of direct oral anticoagulants (DOACs), from 18 individuals receiving DOAC prescriptions (IRDOACP) (0.1 (95% CI 0.08 to 0.23) per 100 persons) in 2010, to 3016 IRDOACP (17.6 (95% CI 17.1 to 18.2) per 100 persons) in 2015, during the same period. Conclusions Prescribing of OACs in individuals with T2DM increased from 2001 to 2015. Since the introduction of DOACs, there has been a clear shift in prescribing towards these agents. Future studies are needed to assess the safety of coadministration of OAC medications and antidiabetic therapy with T2DM.
Persistent Identifierhttp://hdl.handle.net/10722/284681
ISSN
2020 Impact Factor: 2.692
2015 SCImago Journal Rankings: 1.448
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorAlwafi, H-
dc.contributor.authorWei, L-
dc.contributor.authorNaser, AY-
dc.contributor.authorMongkhon, P-
dc.contributor.authorTse, G-
dc.contributor.authorMan, KKC-
dc.contributor.authorBell, JS-
dc.contributor.authorIlomaki, J-
dc.contributor.authorFang, G-
dc.contributor.authorWong, ICK-
dc.date.accessioned2020-08-07T09:01:10Z-
dc.date.available2020-08-07T09:01:10Z-
dc.date.issued2020-
dc.identifier.citationBMJ Open, 2020, v. 10 n. 5, p. article no. e034573-
dc.identifier.issn2044-6055-
dc.identifier.urihttp://hdl.handle.net/10722/284681-
dc.description.abstractObjective: To evaluate oral anticoagulant (OAC) prescribing trends in type 2 diabetes mellitus (T2DM) in the UK from 2001 to 2015. Design: A cross-sectional drug utilisation study. Setting: Electronic health records from The Health Improvement Network primary care database in the UK. Participants: Individuals with T2DM who received a record of OAC prescription. Outcome measures: The prescribing trends of OAC medications in individuals with T2DM were examined from 2001 to 2015, stratified by age, gender and therapeutic classifications. Results A total of 361 635 individuals with T2DM were identified, of whom 36 570 were prescribed OAC from 2001 to 2015. The prevalence of OAC prescribing increased by 50.0%, from 1781 individuals receiving OAC prescriptions (IROACP) (4.4 (95% CI 4.2 to 4.6) per 100 persons) in 2001, to 17 070 IROACP (6.6 (95% CI 6.5 to 6.7) per 100 persons) in 2015. The prevalence of warfarin prescribing decreased by 14.0%, from 1761 individuals receiving warfarin prescriptions (IRWP) (98.9 (95% CI 98.4 to 99.4) per 100 persons) in 2001, to 14 533 IRWP (85.1 (95% CI 84.6 to 85.7) per 100 persons) in 2015. This corresponded with increased prescribing of direct oral anticoagulants (DOACs), from 18 individuals receiving DOAC prescriptions (IRDOACP) (0.1 (95% CI 0.08 to 0.23) per 100 persons) in 2010, to 3016 IRDOACP (17.6 (95% CI 17.1 to 18.2) per 100 persons) in 2015, during the same period. Conclusions Prescribing of OACs in individuals with T2DM increased from 2001 to 2015. Since the introduction of DOACs, there has been a clear shift in prescribing towards these agents. Future studies are needed to assess the safety of coadministration of OAC medications and antidiabetic therapy with T2DM.-
dc.languageeng-
dc.publisherBMJ Publishing Group: BMJ Open. The Journal's web site is located at http://bmjopen.bmj.com-
dc.relation.ispartofBMJ Open-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectage-
dc.subjectaged-
dc.subjectatrial fibrillation-
dc.subjectcohort analysis-
dc.subjectcontrolled study-
dc.titleTrends in oral anticoagulant prescribing in individuals with type 2 diabetes mellitus: a population-based study in the UK-
dc.typeArticle-
dc.identifier.emailMan, KKC: mkckth@hku.hk-
dc.identifier.emailWong, ICK: wongick@hku.hk-
dc.identifier.authorityWong, ICK=rp01480-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1136/bmjopen-2019-034573-
dc.identifier.pmid32414823-
dc.identifier.pmcidPMC7232627-
dc.identifier.scopuseid_2-s2.0-85084785760-
dc.identifier.hkuros311742-
dc.identifier.volume10-
dc.identifier.issue5-
dc.identifier.spagearticle no. e034573-
dc.identifier.epagearticle no. e034573-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl2044-6055-

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