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Article: The pontine-driven somatic gaze tract contributes to affective processing in humans

TitleThe pontine-driven somatic gaze tract contributes to affective processing in humans
Authors
KeywordsPons
Emotion
Affective processing
fMRIDTI
Functional connectivity
Issue Date2020
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
NeuroImage, 2020, v. 213, p. article no. 116692 How to Cite?
AbstractThe relevance of subcortical structures for affective processing is not fully understood. Inspired by the gerbil retino-raphe pathway that has been shown to regulate affective behavior and previous human work showing that the pontine region is important for processing emotion, we asked whether well-established tracts in humans traveling between the eye and the brain stem contribute to functions beyond their conventionally understood roles. Here we report neuroimaging findings showing that optic chiasm-brain stem diffusivity predict responses reflecting perceived arousal and valence. Analyses of subsequent task-evoked connectivity further revealed that visual affective processing implicates the brain stem, particularly the pontine region at an early stage of the cascade, projecting to cortico-limbic regions in a feedforward manner. The optimal model implies that all intrinsic connections between the regions of interest are unidirectional and outwards from the pontine region. These findings suggest that affective processing implicates regions outside the cortico-limbic network. The involvement of a phylogenetically older locus in the pons that has consequences in oculomotor control may imply adaptive consequences of affect detection.
Persistent Identifierhttp://hdl.handle.net/10722/284664
ISSN
2020 Impact Factor: 6.556
2015 SCImago Journal Rankings: 4.464
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWONG, JJ-
dc.contributor.authorChang, DHF-
dc.contributor.authorQI, D-
dc.contributor.authorMen, W-
dc.contributor.authorGao, JH-
dc.contributor.authorLee, TMC-
dc.date.accessioned2020-08-07T09:00:55Z-
dc.date.available2020-08-07T09:00:55Z-
dc.date.issued2020-
dc.identifier.citationNeuroImage, 2020, v. 213, p. article no. 116692-
dc.identifier.issn1053-8119-
dc.identifier.urihttp://hdl.handle.net/10722/284664-
dc.description.abstractThe relevance of subcortical structures for affective processing is not fully understood. Inspired by the gerbil retino-raphe pathway that has been shown to regulate affective behavior and previous human work showing that the pontine region is important for processing emotion, we asked whether well-established tracts in humans traveling between the eye and the brain stem contribute to functions beyond their conventionally understood roles. Here we report neuroimaging findings showing that optic chiasm-brain stem diffusivity predict responses reflecting perceived arousal and valence. Analyses of subsequent task-evoked connectivity further revealed that visual affective processing implicates the brain stem, particularly the pontine region at an early stage of the cascade, projecting to cortico-limbic regions in a feedforward manner. The optimal model implies that all intrinsic connections between the regions of interest are unidirectional and outwards from the pontine region. These findings suggest that affective processing implicates regions outside the cortico-limbic network. The involvement of a phylogenetically older locus in the pons that has consequences in oculomotor control may imply adaptive consequences of affect detection.-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg-
dc.relation.ispartofNeuroImage-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectPons-
dc.subjectEmotion-
dc.subjectAffective processing-
dc.subjectfMRIDTI-
dc.subjectFunctional connectivity-
dc.titleThe pontine-driven somatic gaze tract contributes to affective processing in humans-
dc.typeArticle-
dc.identifier.emailChang, DHF: changd@hku.hk-
dc.identifier.emailLee, TMC: tmclee@hku.hk-
dc.identifier.authorityChang, DHF=rp02272-
dc.identifier.authorityLee, TMC=rp00564-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.neuroimage.2020.116692-
dc.identifier.pmid32135263-
dc.identifier.scopuseid_2-s2.0-85081113565-
dc.identifier.hkuros311911-
dc.identifier.volume213-
dc.identifier.spagearticle no. 116692-
dc.identifier.epagearticle no. 116692-
dc.identifier.isiWOS:000525321000037-
dc.publisher.placeUnited States-
dc.identifier.issnl1053-8119-

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