File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1099/jmm.0.001013
- Scopus: eid_2-s2.0-85071782949
- PMID: 31329093
- WOS: WOS:000484370500015
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Structures of SCCmec elements in methicillin-resistant Staphylococcus lugdunensis are closely related to those harboured by community-associated methicillin-resistant Staphylococcus aureus
Title | Structures of SCCmec elements in methicillin-resistant Staphylococcus lugdunensis are closely related to those harboured by community-associated methicillin-resistant Staphylococcus aureus |
---|---|
Authors | |
Keywords | methicillin antimicrobial resistance epidemiology molecular epidemiology staphylococci |
Issue Date | 2019 |
Publisher | Microbiology Society. The Journal's web site is located at https://www.microbiologyresearch.org/content/journal/jmm |
Citation | Journal of Medical Microbiology, 2019, v. 68 n. 9, p. 1367-1372 How to Cite? |
Abstract | Methicillin-resistant Staphylococcus lugdunensis (MRSL) is increasingly recognized in healthcare and community settings. To obtain a better understanding of the emergence of MRSL, this study characterized the structure and content of the SCCmec elements harboured by 36 MRSL isolates obtained from diverse sources in Hong Kong from 2008 to 2017. The isolates were investigated by whole-genome sequencing. SCCmec types and subtypes were assigned according to the guidelines from the International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements. The sequence type (ST)–SCCmec combinations in the 36 MRSL isolates were as follows: ST3–SCCmec IV (n=2), ST3–SCCmec V (n=28), ST27–SCCmec V (n=5) and ST42–SCCmec V (n=1). The two SCCmec IV elements were highly similar to the SCCmec IV element harboured by the community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strain, JCSC6668. The J3–mec complex–J2 regions in the SCCmec V elements were highly similar to the corresponding regions in the CA-MRSA strains PM1 (n=13) or WIS (n=21). Based on the J1 to J3 sequences, the SCCmec V elements can be categorized into nine different subtypes. Our findings highlight the diversified structures of SCCmec elements among MRSL strains and their close relationship with SCCmec elements harboured by CA-MRSA. |
Persistent Identifier | http://hdl.handle.net/10722/284587 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.752 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liu, MCJ | - |
dc.contributor.author | Cao, H | - |
dc.contributor.author | Lau, A | - |
dc.contributor.author | Chow, KH | - |
dc.contributor.author | Lai, ELY | - |
dc.contributor.author | Tse, CWS | - |
dc.contributor.author | Wu, AKL | - |
dc.contributor.author | Ho, PL | - |
dc.date.accessioned | 2020-08-07T08:59:46Z | - |
dc.date.available | 2020-08-07T08:59:46Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Journal of Medical Microbiology, 2019, v. 68 n. 9, p. 1367-1372 | - |
dc.identifier.issn | 0022-2615 | - |
dc.identifier.uri | http://hdl.handle.net/10722/284587 | - |
dc.description.abstract | Methicillin-resistant Staphylococcus lugdunensis (MRSL) is increasingly recognized in healthcare and community settings. To obtain a better understanding of the emergence of MRSL, this study characterized the structure and content of the SCCmec elements harboured by 36 MRSL isolates obtained from diverse sources in Hong Kong from 2008 to 2017. The isolates were investigated by whole-genome sequencing. SCCmec types and subtypes were assigned according to the guidelines from the International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements. The sequence type (ST)–SCCmec combinations in the 36 MRSL isolates were as follows: ST3–SCCmec IV (n=2), ST3–SCCmec V (n=28), ST27–SCCmec V (n=5) and ST42–SCCmec V (n=1). The two SCCmec IV elements were highly similar to the SCCmec IV element harboured by the community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strain, JCSC6668. The J3–mec complex–J2 regions in the SCCmec V elements were highly similar to the corresponding regions in the CA-MRSA strains PM1 (n=13) or WIS (n=21). Based on the J1 to J3 sequences, the SCCmec V elements can be categorized into nine different subtypes. Our findings highlight the diversified structures of SCCmec elements among MRSL strains and their close relationship with SCCmec elements harboured by CA-MRSA. | - |
dc.language | eng | - |
dc.publisher | Microbiology Society. The Journal's web site is located at https://www.microbiologyresearch.org/content/journal/jmm | - |
dc.relation.ispartof | Journal of Medical Microbiology | - |
dc.rights | Journal of Medical Microbiology. Copyright © Microbiology Society. | - |
dc.rights | © Liu, MCJ; Cao, H; Lau, A ...(et al), 2019. The definitive peer reviewed, edited version of this article is published in Journal of Medical Microbiology, 2019, v. 68 n. 9, p. 1367-1372, DOI: http://dx.doi.org/10.1099/jmm.0.001013 | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | methicillin | - |
dc.subject | antimicrobial resistance epidemiology | - |
dc.subject | molecular epidemiology | - |
dc.subject | staphylococci | - |
dc.title | Structures of SCCmec elements in methicillin-resistant Staphylococcus lugdunensis are closely related to those harboured by community-associated methicillin-resistant Staphylococcus aureus | - |
dc.type | Article | - |
dc.identifier.email | Cao, H: hcao@hku.hk | - |
dc.identifier.email | Chow, KH: khchowb@hku.hk | - |
dc.identifier.email | Wu, AKL: alanklwu@hkucc.hku.hk | - |
dc.identifier.email | Ho, PL: plho@hku.hk | - |
dc.identifier.authority | Chow, KH=rp00370 | - |
dc.identifier.authority | Ho, PL=rp00406 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1099/jmm.0.001013 | - |
dc.identifier.pmid | 31329093 | - |
dc.identifier.scopus | eid_2-s2.0-85071782949 | - |
dc.identifier.hkuros | 312550 | - |
dc.identifier.volume | 68 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 1367 | - |
dc.identifier.epage | 1372 | - |
dc.identifier.isi | WOS:000484370500015 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0022-2615 | - |