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Article: Serotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation

TitleSerotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation
Authors
KeywordsDeep brain stimulation
Periaqueductal gray
Fear-like behaviour
Dopamine
Serotonergic system
Issue Date2020
PublisherSpringer. The Journal's web site is located at http://link.springer.de/link/service/journals/00429/index.htm
Citation
Brain Structure and Function, 2020, Epub 2020-06-27 How to Cite?
AbstractElectrical stimulation of the dorsolateral periaqueductal gray (dlPAG) in rats has been shown to elicit panic-like behaviour and can be a useful tool for modelling anticipatory fear and agoraphobia. In this study, we further analysed our previous data on the effects of escitalopram (a selective serotonin reuptake inhibitor, SSRI) and buspirone (a 5-HT1A receptor partial agonist) on dlPAG-induced anticipatory fear behaviour in a rat model using freezing as a measure. We then used tyrosine hydroxylase (TH) immunohistochemistry to probe the effects on dopaminergic neurons. We showed that acute treatment of escitalopram, but not buspirone, was effective in reducing anticipatory freezing behaviour, chronic administrations of both drugs were comparably effective. We found that the dlPAG stimulation induced increase number of dopaminergic neurons in the ventral tegmental area (VTA) was reversed in both chronic buspirone and escitalopram groups with a strong positive correlation between the number of dopaminergic neurons and freezing in the VTA. We further showed positive correlations between dopaminergic neurons in the VTA and substantia nigra pars compacta in escitalopram and buspirone groups, respectively. Overall, we showed that chronic treatment with an SSRI and a 5-HT1A agonist reverses the dlPAG stimulation induced increase in number of dopaminergic neurons in the VTA and these effects seem to be associated with reduced anticipatory freezing behaviour.
Persistent Identifierhttp://hdl.handle.net/10722/284515
ISSN
2019 Impact Factor: 3.298
2015 SCImago Journal Rankings: 2.035

 

DC FieldValueLanguage
dc.contributor.authorTAN, SZK-
dc.contributor.authorTemel, Y-
dc.contributor.authorChan, AY-
dc.contributor.authorMok, ATC-
dc.contributor.authorPERUCHO, JAU-
dc.contributor.authorBlokland, A-
dc.contributor.authorAquili, L-
dc.contributor.authorLim, WL-
dc.contributor.authorLim, LW-
dc.date.accessioned2020-08-07T08:58:45Z-
dc.date.available2020-08-07T08:58:45Z-
dc.date.issued2020-
dc.identifier.citationBrain Structure and Function, 2020, Epub 2020-06-27-
dc.identifier.issn1863-2653-
dc.identifier.urihttp://hdl.handle.net/10722/284515-
dc.description.abstractElectrical stimulation of the dorsolateral periaqueductal gray (dlPAG) in rats has been shown to elicit panic-like behaviour and can be a useful tool for modelling anticipatory fear and agoraphobia. In this study, we further analysed our previous data on the effects of escitalopram (a selective serotonin reuptake inhibitor, SSRI) and buspirone (a 5-HT1A receptor partial agonist) on dlPAG-induced anticipatory fear behaviour in a rat model using freezing as a measure. We then used tyrosine hydroxylase (TH) immunohistochemistry to probe the effects on dopaminergic neurons. We showed that acute treatment of escitalopram, but not buspirone, was effective in reducing anticipatory freezing behaviour, chronic administrations of both drugs were comparably effective. We found that the dlPAG stimulation induced increase number of dopaminergic neurons in the ventral tegmental area (VTA) was reversed in both chronic buspirone and escitalopram groups with a strong positive correlation between the number of dopaminergic neurons and freezing in the VTA. We further showed positive correlations between dopaminergic neurons in the VTA and substantia nigra pars compacta in escitalopram and buspirone groups, respectively. Overall, we showed that chronic treatment with an SSRI and a 5-HT1A agonist reverses the dlPAG stimulation induced increase in number of dopaminergic neurons in the VTA and these effects seem to be associated with reduced anticipatory freezing behaviour.-
dc.languageeng-
dc.publisherSpringer. The Journal's web site is located at http://link.springer.de/link/service/journals/00429/index.htm-
dc.relation.ispartofBrain Structure and Function-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI]-
dc.subjectDeep brain stimulation-
dc.subjectPeriaqueductal gray-
dc.subjectFear-like behaviour-
dc.subjectDopamine-
dc.subjectSerotonergic system-
dc.titleSerotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation-
dc.typeArticle-
dc.identifier.emailLim, LW: limlw@hku.hk-
dc.identifier.authorityLim, LW=rp02088-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00429-020-02102-w-
dc.identifier.scopuseid_2-s2.0-85087017591-
dc.identifier.hkuros311496-
dc.identifier.volumeEpub 2020-06-27-
dc.publisher.placeGermany-

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