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- Publisher Website: 10.3389/fphar.2020.00548
- Scopus: eid_2-s2.0-85084760490
- PMID: 32425789
- WOS: WOS:000536107300001
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Article: Targeting Hepatic Stellate Cells for the Treatment of Liver Fibrosis by Natural Products: Is It the Dawning of a New Era?
Title | Targeting Hepatic Stellate Cells for the Treatment of Liver Fibrosis by Natural Products: Is It the Dawning of a New Era? |
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Authors | |
Keywords | apoptosis cell activation cell aging Chinese medicine drug efficacy |
Issue Date | 2020 |
Publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/pharmacology |
Citation | Frontiers in Pharmacology, 2020, v. 11, p. article no. 548 How to Cite? |
Abstract | Liver fibrosis is a progressive liver damage condition that is worth studying widely. It is important to target and alleviate the disease at an early stage before turning into later cirrhosis or liver cancer. There are currently no direct medicines targeting the attenuation or reversal of liver fibrosis, and so there is an urgent need to look into this area. Traditional Chinese Medicine has a long history in using herbal medicines to treat liver diseases including fibrosis. It is time to integrate the ancient wisdom with modern science and technology to look for the best solution to the disease. In this review, the principal concept of the pathology of liver fibrosis will be described, and then some of the single compounds isolated from herbal medicines, including salvianolic acids, oxymatrine, curcumin, tetrandrine, etc. will be discussed from their effects to the molecular mechanism behind. Molecular targets of the compounds are analyzed by network pharmacology approach, and TGFβ/SMAD was identified as the most common pathway. This review serves to summarize the current findings of herbal medicines combining with modern medicines in the area of fibrosis. It hopefully provides insights in further pharmaceutical research directions. |
Persistent Identifier | http://hdl.handle.net/10722/284279 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 1.066 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chan, YT | - |
dc.contributor.author | Wang, N | - |
dc.contributor.author | Tan, HY | - |
dc.contributor.author | Li, S | - |
dc.contributor.author | Feng, Y | - |
dc.date.accessioned | 2020-07-20T05:57:28Z | - |
dc.date.available | 2020-07-20T05:57:28Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Frontiers in Pharmacology, 2020, v. 11, p. article no. 548 | - |
dc.identifier.issn | 1663-9812 | - |
dc.identifier.uri | http://hdl.handle.net/10722/284279 | - |
dc.description.abstract | Liver fibrosis is a progressive liver damage condition that is worth studying widely. It is important to target and alleviate the disease at an early stage before turning into later cirrhosis or liver cancer. There are currently no direct medicines targeting the attenuation or reversal of liver fibrosis, and so there is an urgent need to look into this area. Traditional Chinese Medicine has a long history in using herbal medicines to treat liver diseases including fibrosis. It is time to integrate the ancient wisdom with modern science and technology to look for the best solution to the disease. In this review, the principal concept of the pathology of liver fibrosis will be described, and then some of the single compounds isolated from herbal medicines, including salvianolic acids, oxymatrine, curcumin, tetrandrine, etc. will be discussed from their effects to the molecular mechanism behind. Molecular targets of the compounds are analyzed by network pharmacology approach, and TGFβ/SMAD was identified as the most common pathway. This review serves to summarize the current findings of herbal medicines combining with modern medicines in the area of fibrosis. It hopefully provides insights in further pharmaceutical research directions. | - |
dc.language | eng | - |
dc.publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/pharmacology | - |
dc.relation.ispartof | Frontiers in Pharmacology | - |
dc.rights | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | apoptosis | - |
dc.subject | cell activation | - |
dc.subject | cell aging | - |
dc.subject | Chinese medicine | - |
dc.subject | drug efficacy | - |
dc.title | Targeting Hepatic Stellate Cells for the Treatment of Liver Fibrosis by Natural Products: Is It the Dawning of a New Era? | - |
dc.type | Article | - |
dc.identifier.email | Chan, YT: ecyt1@hku.hk | - |
dc.identifier.email | Wang, N: ckwang@hku.hk | - |
dc.identifier.email | Tan, HY: hyhtan@hku.hk | - |
dc.identifier.email | Li, S: lishaha@hku.hk | - |
dc.identifier.email | Feng, Y: yfeng@hku.hk | - |
dc.identifier.authority | Wang, N=rp02075 | - |
dc.identifier.authority | Feng, Y=rp00466 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3389/fphar.2020.00548 | - |
dc.identifier.pmid | 32425789 | - |
dc.identifier.pmcid | PMC7212390 | - |
dc.identifier.scopus | eid_2-s2.0-85084760490 | - |
dc.identifier.hkuros | 311482 | - |
dc.identifier.volume | 11 | - |
dc.identifier.spage | article no. 548 | - |
dc.identifier.epage | article no. 548 | - |
dc.identifier.isi | WOS:000536107300001 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 1663-9812 | - |