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Article: Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer's disease detected by dynamic glucose-enhanced MRI

TitleAltered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer's disease detected by dynamic glucose-enhanced MRI
Authors
Issue Date2020
PublisherAmerican Association for the Advancement of Science: Science Advances. The Journal's web site is located at http://www.scienceadvances.org/
Citation
Science Advances, 2020, v. 6 n. 20, p. article no. eaba3884 How to Cite?
AbstractAltered cerebral glucose uptake is one of the hallmarks of Alzheimer’s disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor D-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher uptake in parenchyma of young (6 months) transgenic AD mice compared to age-matched wild-type (WT) mice. Notably lower uptakes were observed in parenchyma and CSF of old (16 months) AD mice. Both young and old AD mice had an obviously slower CSF clearance than age-matched WT mice. This resembles recent reports of the hampered CSF clearance that leads to protein accumulation in the brain. These findings suggest that DGE MRI can identify altered glucose uptake and clearance in young AD mice upon the emergence of amyloid plaques. DGE MRI of brain parenchyma and CSF has potential for early AD stratification, especially at 3T clinical field strength MRI.
Persistent Identifierhttp://hdl.handle.net/10722/284068
ISSN
2019 Impact Factor: 13.116

 

DC FieldValueLanguage
dc.contributor.authorHuang, J-
dc.contributor.authorvan Zijl, PCM-
dc.contributor.authorHan, X-
dc.contributor.authorDong, M-
dc.contributor.authorCheung, GWY-
dc.contributor.authorTse, KH-
dc.contributor.authorKnutsson, L-
dc.contributor.authorChen, L-
dc.contributor.authorLai, JHC-
dc.contributor.authorWu, EX-
dc.contributor.authorXu, J-
dc.contributor.authorChan, KWY-
dc.date.accessioned2020-07-20T05:55:50Z-
dc.date.available2020-07-20T05:55:50Z-
dc.date.issued2020-
dc.identifier.citationScience Advances, 2020, v. 6 n. 20, p. article no. eaba3884-
dc.identifier.issn2375-2548-
dc.identifier.urihttp://hdl.handle.net/10722/284068-
dc.description.abstractAltered cerebral glucose uptake is one of the hallmarks of Alzheimer’s disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor D-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher uptake in parenchyma of young (6 months) transgenic AD mice compared to age-matched wild-type (WT) mice. Notably lower uptakes were observed in parenchyma and CSF of old (16 months) AD mice. Both young and old AD mice had an obviously slower CSF clearance than age-matched WT mice. This resembles recent reports of the hampered CSF clearance that leads to protein accumulation in the brain. These findings suggest that DGE MRI can identify altered glucose uptake and clearance in young AD mice upon the emergence of amyloid plaques. DGE MRI of brain parenchyma and CSF has potential for early AD stratification, especially at 3T clinical field strength MRI.-
dc.languageeng-
dc.publisherAmerican Association for the Advancement of Science: Science Advances. The Journal's web site is located at http://www.scienceadvances.org/-
dc.relation.ispartofScience Advances-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleAltered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer's disease detected by dynamic glucose-enhanced MRI-
dc.typeArticle-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.identifier.authorityWu, EX=rp00193-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1126/sciadv.aba3884-
dc.identifier.scopuseid_2-s2.0-85084787075-
dc.identifier.hkuros311199-
dc.identifier.volume6-
dc.identifier.issue20-
dc.identifier.spagearticle no. eaba3884-
dc.identifier.epagearticle no. eaba3884-
dc.publisher.placeUnited States-

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