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Article: Local application of enamel matrix derivative prevents acute systemic inflammation after periodontal regenerative surgery: A randomized controlled clinical trial

TitleLocal application of enamel matrix derivative prevents acute systemic inflammation after periodontal regenerative surgery: A randomized controlled clinical trial
Authors
KeywordsC‐reactive protein
enamel matrix derivative
periodontitis
Issue Date2020
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-051X
Citation
Journal of Clinical Periodontology, 2020, v. 47 n. 6, p. 747-755 How to Cite?
AbstractAim: The aim of this study was to compare surgical treatment of periodontal intra‐bony defects (IBD) with or without the adjunct of enamel matrix derivative (EMD) in terms of acute‐phase responses in healthy patients. Methods: Thirty‐eight periodontitis‐affected subjects, one IDB each, were randomized to minimally invasive periodontal surgery (MIS) with or without EMD. Periodontal parameters were recorded at baseline and 6‐months. Blood samples were collected at baseline, 1, 7 and 180 days after treatment. Results: At 24 hr, the group treated MIS with EMD showed lower values of C‐reactive protein (CRP; p < .01) as no inflammatory perturbation was noticed. Conversely, MIS group resulted in an acute inflammatory response at 24 hr (p < .05) that regressed to its baseline values at day 7. The EMD group showed a higher number of cases without residual BOP or PPD ≥ 5mm 6 months after surgery (p < .05), and post‐surgical gingival recession was lower (p < .05). Conclusions: The adjunctive application of EMD during surgical treatment resulted in a minor increase in serum CRP 24‐hr after surgery. These findings suggest a possible systemic anti‐inflammatory effect of EMD. Within its limitations, this pilot trial confirmed better clinical periodontal outcomes in the EMD group. NCT03590093.
Persistent Identifierhttp://hdl.handle.net/10722/283357
ISSN
2023 Impact Factor: 5.8
2023 SCImago Journal Rankings: 2.249
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGraziani, F-
dc.contributor.authorPeric, M-
dc.contributor.authorMarhl, U-
dc.contributor.authorPetrini, M-
dc.contributor.authorBettini, L-
dc.contributor.authorTonetti, M-
dc.contributor.authorGennai, S-
dc.date.accessioned2020-06-22T02:55:26Z-
dc.date.available2020-06-22T02:55:26Z-
dc.date.issued2020-
dc.identifier.citationJournal of Clinical Periodontology, 2020, v. 47 n. 6, p. 747-755-
dc.identifier.issn0303-6979-
dc.identifier.urihttp://hdl.handle.net/10722/283357-
dc.description.abstractAim: The aim of this study was to compare surgical treatment of periodontal intra‐bony defects (IBD) with or without the adjunct of enamel matrix derivative (EMD) in terms of acute‐phase responses in healthy patients. Methods: Thirty‐eight periodontitis‐affected subjects, one IDB each, were randomized to minimally invasive periodontal surgery (MIS) with or without EMD. Periodontal parameters were recorded at baseline and 6‐months. Blood samples were collected at baseline, 1, 7 and 180 days after treatment. Results: At 24 hr, the group treated MIS with EMD showed lower values of C‐reactive protein (CRP; p < .01) as no inflammatory perturbation was noticed. Conversely, MIS group resulted in an acute inflammatory response at 24 hr (p < .05) that regressed to its baseline values at day 7. The EMD group showed a higher number of cases without residual BOP or PPD ≥ 5mm 6 months after surgery (p < .05), and post‐surgical gingival recession was lower (p < .05). Conclusions: The adjunctive application of EMD during surgical treatment resulted in a minor increase in serum CRP 24‐hr after surgery. These findings suggest a possible systemic anti‐inflammatory effect of EMD. Within its limitations, this pilot trial confirmed better clinical periodontal outcomes in the EMD group. NCT03590093.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-051X-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectC‐reactive protein-
dc.subjectenamel matrix derivative-
dc.subjectperiodontitis-
dc.titleLocal application of enamel matrix derivative prevents acute systemic inflammation after periodontal regenerative surgery: A randomized controlled clinical trial-
dc.typeArticle-
dc.identifier.emailTonetti, M: tonetti@hku.hk-
dc.identifier.authorityTonetti, M=rp02178-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/jcpe.13270-
dc.identifier.pmid32163634-
dc.identifier.scopuseid_2-s2.0-85081729956-
dc.identifier.hkuros310426-
dc.identifier.volume47-
dc.identifier.issue6-
dc.identifier.spage747-
dc.identifier.epage755-
dc.identifier.isiWOS:000536490300010-
dc.publisher.placeUnited States-
dc.identifier.issnl0303-6979-

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