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Article: Protracted morphological changes in the corticospinal tract within the cervical spinal cord after intracerebral hemorrhage in the right striatum of mice

TitleProtracted morphological changes in the corticospinal tract within the cervical spinal cord after intracerebral hemorrhage in the right striatum of mice
Authors
Keywordsintracerebral hemorrhage
hemorrhagic stroke
corticospinal tract integrity
spinal cord changes
collagenase mice model
Issue Date2020
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/neuroscience
Citation
Frontiers in Neuroscience, 2020, v. 14, p. article no. 506 How to Cite?
AbstractIntracerebral hemorrhage (ICH) is associated with high morbidity and mortality rates. Currently, there is no promising treatment that improves prognosis significantly. While a thorough investigation of the pathological process within the primary site of injury in the brain has been conducted by the research field, the focus was mainly on gray matter injury, which partly accounted for the failure of discovery of clinically efficacious treatments. It is not until recent years that white matter (WM) injury in the brain after subcortical ICH was examined. As WM tracts form networks between different regions, damage to fibers should impair brain connectivity, resulting in functional impairment. Although WM changes have been demonstrated in the brain after ICH, alterations distant from the initial injury site down in the spinal cord are unclear. This longitudinal study, for the first time, revealed prolonged morphological changes of the contralesional dorsal corticospinal tract (CST) in the spinal cord 5 weeks after experimental ICH in mice by confocal microscopy and transmission electron microscopy, implying that the structural integrity of the CST was compromised extensively after ICH. Given the important role of CST in motor function, future translational studies targeting motor recovery should delineate the treatment effects on CST integrity.
Persistent Identifierhttp://hdl.handle.net/10722/283243
ISSN
2018 Impact Factor: 3.648

 

DC FieldValueLanguage
dc.contributor.authorNG, ACK-
dc.contributor.authorYAO, M-
dc.contributor.authorCHENG, SY-
dc.contributor.authorLI, J-
dc.contributor.authorHuang, JD-
dc.contributor.authorWu, W-
dc.contributor.authorLeung, GKK-
dc.contributor.authorSun, H-
dc.date.accessioned2020-06-22T02:54:02Z-
dc.date.available2020-06-22T02:54:02Z-
dc.date.issued2020-
dc.identifier.citationFrontiers in Neuroscience, 2020, v. 14, p. article no. 506-
dc.identifier.issn1662-453X-
dc.identifier.urihttp://hdl.handle.net/10722/283243-
dc.description.abstractIntracerebral hemorrhage (ICH) is associated with high morbidity and mortality rates. Currently, there is no promising treatment that improves prognosis significantly. While a thorough investigation of the pathological process within the primary site of injury in the brain has been conducted by the research field, the focus was mainly on gray matter injury, which partly accounted for the failure of discovery of clinically efficacious treatments. It is not until recent years that white matter (WM) injury in the brain after subcortical ICH was examined. As WM tracts form networks between different regions, damage to fibers should impair brain connectivity, resulting in functional impairment. Although WM changes have been demonstrated in the brain after ICH, alterations distant from the initial injury site down in the spinal cord are unclear. This longitudinal study, for the first time, revealed prolonged morphological changes of the contralesional dorsal corticospinal tract (CST) in the spinal cord 5 weeks after experimental ICH in mice by confocal microscopy and transmission electron microscopy, implying that the structural integrity of the CST was compromised extensively after ICH. Given the important role of CST in motor function, future translational studies targeting motor recovery should delineate the treatment effects on CST integrity.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/neuroscience-
dc.relation.ispartofFrontiers in Neuroscience-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectintracerebral hemorrhage-
dc.subjecthemorrhagic stroke-
dc.subjectcorticospinal tract integrity-
dc.subjectspinal cord changes-
dc.subjectcollagenase mice model-
dc.titleProtracted morphological changes in the corticospinal tract within the cervical spinal cord after intracerebral hemorrhage in the right striatum of mice-
dc.typeArticle-
dc.identifier.emailHuang, JD: jdhuang@hku.hk-
dc.identifier.emailLeung, GKK: gkkleung@hku.hk-
dc.identifier.emailSun, H: haitao88@hku.hk-
dc.identifier.authorityHuang, JD=rp00451-
dc.identifier.authorityWu, W=rp00419-
dc.identifier.authorityLeung, GKK=rp00522-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fnins.2020.00506-
dc.identifier.scopuseid_2-s2.0-85086775728-
dc.identifier.hkuros310392-
dc.identifier.volume14-
dc.identifier.spagearticle no. 506-
dc.identifier.epagearticle no. 506-
dc.publisher.placeSwitzerland-

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