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Article: Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins

TitleIdentifying SARS-CoV-2-related coronaviruses in Malayan pangolins
Authors
KeywordsChina
human
metagenomics
nonhuman
Pholidota (animal)
Issue Date2020
PublisherNature Research (part of Springer Nature). The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 2020, Epub 2020-03-26 How to Cite?
AbstractThe ongoing outbreak of viral pneumonia in China and beyond is associated with a novel coronavirus, SARS-CoV-21. This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection2. Although bats are likely reservoir hosts for SARS-CoV-2, the identity of any intermediate host that might have facilitated transfer to humans is unknown. Here, we report the identification of SARS-CoV-2-related coronaviruses in Malayan pangolins (Manis javanica) seized in anti-smuggling operations in southern China. Metagenomic sequencing identified pangolin-associated coronaviruses that belong to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity to SARS-CoV-2 in the receptor-binding domain. The discovery of multiple lineages of pangolin coronavirus and their similarity to SARS-CoV-2 suggests that pangolins should be considered as possible hosts in the emergence of novel coronaviruses and should be removed from wet markets to prevent zoonotic transmission.
DescriptionLink to Free access
Persistent Identifierhttp://hdl.handle.net/10722/282816
ISSN
2019 Impact Factor: 42.778
2015 SCImago Journal Rankings: 21.936

 

DC FieldValueLanguage
dc.contributor.authorLam, TTY-
dc.contributor.authorJia, N-
dc.contributor.authorZhang, YW-
dc.contributor.authorSHUM, MHH-
dc.contributor.authorJiang, JF-
dc.contributor.authorZhu, HC-
dc.contributor.authorTong, YG-
dc.contributor.authorShi, YX-
dc.contributor.authorNI, XB-
dc.contributor.authorLIAO, YS-
dc.contributor.authorLi, WJ-
dc.contributor.authorJiang, BG-
dc.contributor.authorWei, W-
dc.contributor.authorYuan, TT-
dc.contributor.authorZheng, K-
dc.contributor.authorCui, XM-
dc.contributor.authorLi, J-
dc.contributor.authorPei, GQ-
dc.contributor.authorQiang, X-
dc.contributor.authorCheung, WYM-
dc.contributor.authorLi, LF-
dc.contributor.authorSun, FF-
dc.contributor.authorQin, Si-
dc.contributor.authorHuang, JC-
dc.contributor.authorLeung, GM-
dc.contributor.authorHolmes, EC-
dc.contributor.authorHu, YL-
dc.contributor.authorGuan, Y-
dc.contributor.authorCao, WC-
dc.date.accessioned2020-06-05T06:21:53Z-
dc.date.available2020-06-05T06:21:53Z-
dc.date.issued2020-
dc.identifier.citationNature, 2020, Epub 2020-03-26-
dc.identifier.issn0028-0836-
dc.identifier.urihttp://hdl.handle.net/10722/282816-
dc.descriptionLink to Free access-
dc.description.abstractThe ongoing outbreak of viral pneumonia in China and beyond is associated with a novel coronavirus, SARS-CoV-21. This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection2. Although bats are likely reservoir hosts for SARS-CoV-2, the identity of any intermediate host that might have facilitated transfer to humans is unknown. Here, we report the identification of SARS-CoV-2-related coronaviruses in Malayan pangolins (Manis javanica) seized in anti-smuggling operations in southern China. Metagenomic sequencing identified pangolin-associated coronaviruses that belong to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity to SARS-CoV-2 in the receptor-binding domain. The discovery of multiple lineages of pangolin coronavirus and their similarity to SARS-CoV-2 suggests that pangolins should be considered as possible hosts in the emergence of novel coronaviruses and should be removed from wet markets to prevent zoonotic transmission.-
dc.languageeng-
dc.publisherNature Research (part of Springer Nature). The Journal's web site is located at http://www.nature.com/nature-
dc.relation.ispartofNature-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI]-
dc.subjectChina-
dc.subjecthuman-
dc.subjectmetagenomics-
dc.subjectnonhuman-
dc.subjectPholidota (animal)-
dc.titleIdentifying SARS-CoV-2-related coronaviruses in Malayan pangolins-
dc.typeArticle-
dc.identifier.emailLam, TTY: ttylam@hku.hk-
dc.identifier.emailZhu, HC: zhuhch@hku.hk-
dc.identifier.emailCheung, WYM: cheungcl@hku.hk-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hk-
dc.identifier.authorityLam, TTY=rp01733-
dc.identifier.authorityZhu, HC=rp01535-
dc.identifier.authorityLeung, GM=rp00460-
dc.identifier.authorityGuan, Y=rp00397-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/s41586-020-2169-0-
dc.identifier.pmid32218527-
dc.identifier.scopuseid_2-s2.0-85082794498-
dc.identifier.hkuros309990-
dc.identifier.volumeEpub 2020-03-26-
dc.publisher.placeUnited Kingdom-
dc.identifier.f1000737621625-

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