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Article: Effects of fasting on the expression pattern of FGFs in different skeletal muscle fibre types and sexes in mice

TitleEffects of fasting on the expression pattern of FGFs in different skeletal muscle fibre types and sexes in mice
Authors
KeywordsFasting
Fibroblast growth factor
Skeletal muscle
Fibre type
Sex
Issue Date2020
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.bsd-journal.com
Citation
Biology of Sex Differences, 2020, v. 11, p. article no. 9 How to Cite?
AbstractFibroblast growth factors (FGFs) belong to a large family comprising 22 FGF polypeptides that are widely expressed in tissues. Most of the FGFs can be secreted and involved in the regulation of skeletal muscle function and structure. However, the role of fasting on FGF expression pattern in skeletal muscles remains unknown. In this study, we combined bioinformatics analysis and in vivo studies to explore the effect of 24-h fasting on the expression of Fgfs in slow-twitch soleus and fast-twitch tibialis anterior (TA) muscle from male and female C57BL/6 mice. We found that fasting significantly affected the expression of many Fgfs in mouse skeletal muscle. Furthermore, skeletal muscle fibre type and sex also influenced Fgf expression and response to fasting. We observed that in both male and female mice fasting reduced Fgf6 and Fgf11 in the TA muscle rather than the soleus. Moreover, fasting reduced Fgf8 expression in the soleus and TA muscles in female mice rather than in male mice. Fasting also increased Fgf21 expression in female soleus muscle and female and male plasma. Fasting reduced Fgf2 and Fgf18 expression levels without fibre-type and sex-dependent effects in mice. We further found that fasting decreased the expression of an FGF activation marker gene—Flrt2 in the TA muscle but not in the soleus muscle in both male and female mice. This study revealed the expression profile of Fgfs in different skeletal muscle fibre types and different sexes and provides clues to the interaction between the skeletal muscle and other organs, which deserves future investigations.
Persistent Identifierhttp://hdl.handle.net/10722/282545
ISSN
2018 Impact Factor: 3.188
2015 SCImago Journal Rankings: 2.250
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorJia, W-H-
dc.contributor.authorWang, N-Q-
dc.contributor.authorYin, L-
dc.contributor.authorChen, X-
dc.contributor.authorHou, B-Y-
dc.contributor.authorWang, J-H-
dc.contributor.authorQiang, G-F-
dc.contributor.authorChan, CB-
dc.contributor.authorYang, X-Y-
dc.contributor.authorDu, G-H-
dc.date.accessioned2020-05-15T05:29:30Z-
dc.date.available2020-05-15T05:29:30Z-
dc.date.issued2020-
dc.identifier.citationBiology of Sex Differences, 2020, v. 11, p. article no. 9-
dc.identifier.issn2042-6410-
dc.identifier.urihttp://hdl.handle.net/10722/282545-
dc.description.abstractFibroblast growth factors (FGFs) belong to a large family comprising 22 FGF polypeptides that are widely expressed in tissues. Most of the FGFs can be secreted and involved in the regulation of skeletal muscle function and structure. However, the role of fasting on FGF expression pattern in skeletal muscles remains unknown. In this study, we combined bioinformatics analysis and in vivo studies to explore the effect of 24-h fasting on the expression of Fgfs in slow-twitch soleus and fast-twitch tibialis anterior (TA) muscle from male and female C57BL/6 mice. We found that fasting significantly affected the expression of many Fgfs in mouse skeletal muscle. Furthermore, skeletal muscle fibre type and sex also influenced Fgf expression and response to fasting. We observed that in both male and female mice fasting reduced Fgf6 and Fgf11 in the TA muscle rather than the soleus. Moreover, fasting reduced Fgf8 expression in the soleus and TA muscles in female mice rather than in male mice. Fasting also increased Fgf21 expression in female soleus muscle and female and male plasma. Fasting reduced Fgf2 and Fgf18 expression levels without fibre-type and sex-dependent effects in mice. We further found that fasting decreased the expression of an FGF activation marker gene—Flrt2 in the TA muscle but not in the soleus muscle in both male and female mice. This study revealed the expression profile of Fgfs in different skeletal muscle fibre types and different sexes and provides clues to the interaction between the skeletal muscle and other organs, which deserves future investigations.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.bsd-journal.com-
dc.relation.ispartofBiology of Sex Differences-
dc.rightsBiology of Sex Differences. Copyright © BioMed Central Ltd.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectFasting-
dc.subjectFibroblast growth factor-
dc.subjectSkeletal muscle-
dc.subjectFibre type-
dc.subjectSex-
dc.titleEffects of fasting on the expression pattern of FGFs in different skeletal muscle fibre types and sexes in mice-
dc.typeArticle-
dc.identifier.emailChan, CB: chancb@hku.hk-
dc.identifier.authorityChan, CB=rp02140-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s13293-020-00287-7-
dc.identifier.pmid32156311-
dc.identifier.pmcidPMC7063800-
dc.identifier.scopuseid_2-s2.0-85081657949-
dc.identifier.hkuros309977-
dc.identifier.volume11-
dc.identifier.spagearticle no. 9-
dc.identifier.epagearticle no. 9-
dc.publisher.placeUnited Kingdom-

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