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Article: Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

TitleIdentification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants
Authors
KeywordsAsian
breast cancer
cancer risk
controlled study
European
Issue Date2020
PublisherNature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html
Citation
Nature Communications, 2020, v. 11, p. article no. 1217 How to Cite?
AbstractKnown risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P < 5 × 10−8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P < 0.05). In addition, we replicated the associations for 78 of the 166 known risk variants at P < 0.05 in Asians. These findings improve our understanding of breast cancer genetics and etiology and extend previous findings from studies of European descendants to Asian women.
Persistent Identifierhttp://hdl.handle.net/10722/282535
ISSN
2019 Impact Factor: 12.121
2015 SCImago Journal Rankings: 6.539
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorShu, X-
dc.contributor.authorLong, J-
dc.contributor.authorCai, Q-
dc.contributor.authorKweon, S-S-
dc.contributor.authorChoi, J-Y-
dc.contributor.authorKubo, M-
dc.contributor.authorPark, SK-
dc.contributor.authorBolla, MK-
dc.contributor.authorDennis, J-
dc.contributor.authorWang, Q-
dc.contributor.authorYang, Y-H-
dc.contributor.authorShi, J-J-
dc.contributor.authorGuo, X-Y-
dc.contributor.authorLi, B-S-
dc.contributor.authorTao, R-
dc.contributor.authorAronson, KJ-
dc.contributor.authorChan, KYK-
dc.contributor.authorChan, TL-
dc.contributor.authorGao, Y-T-
dc.contributor.authorHartman, M-
dc.contributor.authorKee Ho, W-
dc.contributor.authorIto, H-
dc.contributor.authorIwasaki, M-
dc.contributor.authorIwata, H-
dc.contributor.authorJohn, EM-
dc.contributor.authorKasuga, Y-
dc.contributor.authorKhoo, US-
dc.contributor.authorKim, M-K-
dc.contributor.authorKong, S-Y-
dc.contributor.authorKurian, AW-
dc.contributor.authorKwong, A-
dc.contributor.authorLee, E-S-
dc.contributor.authorLi, J-M-
dc.contributor.authorLophatananon, A-
dc.contributor.authorLow, S-K-
dc.contributor.authorMariapun, S-
dc.contributor.authorMatsuda, K-
dc.contributor.authorMatsuo, K-
dc.contributor.authorMuir, K-
dc.contributor.authorNoh, D-Y-
dc.contributor.authorPark, B-Y-
dc.contributor.authorPark, M-H-
dc.contributor.authorShen, C-Y-
dc.contributor.authorShin, M-H-
dc.contributor.authorSpinelli, JJ-
dc.contributor.authorTakahashi, A-
dc.contributor.authorTseng, C-
dc.contributor.authorTsugane, S-
dc.contributor.authorWu, AH-
dc.contributor.authorXiang, Y-B-
dc.contributor.authorYamaji, T-
dc.contributor.authorZheng, Y-
dc.contributor.authorMilne, RL-
dc.contributor.authorDunning, AM-
dc.contributor.authorPharoah, PDP-
dc.contributor.authorGarcía-Closas, M-
dc.contributor.authorTeo, S-H-
dc.contributor.authorShu, X-O-
dc.contributor.authorKang, D-H-
dc.contributor.authorEaston, DF-
dc.contributor.authorSimard, J-
dc.contributor.authorZheng, W-
dc.date.accessioned2020-05-15T05:29:23Z-
dc.date.available2020-05-15T05:29:23Z-
dc.date.issued2020-
dc.identifier.citationNature Communications, 2020, v. 11, p. article no. 1217-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/282535-
dc.description.abstractKnown risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P < 5 × 10−8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P < 0.05). In addition, we replicated the associations for 78 of the 166 known risk variants at P < 0.05 in Asians. These findings improve our understanding of breast cancer genetics and etiology and extend previous findings from studies of European descendants to Asian women.-
dc.languageeng-
dc.publisherNature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html-
dc.relation.ispartofNature Communications-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAsian-
dc.subjectbreast cancer-
dc.subjectcancer risk-
dc.subjectcontrolled study-
dc.subjectEuropean-
dc.titleIdentification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants-
dc.typeArticle-
dc.identifier.emailChan, KYK: ykchanc@hku.hk-
dc.identifier.emailKhoo, US: uskhoo@hku.hk-
dc.identifier.emailKwong, A: avakwong@hku.hk-
dc.identifier.authorityChan, KYK=rp00453-
dc.identifier.authorityKhoo, US=rp00362-
dc.identifier.authorityKwong, A=rp01734-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41467-020-15046-w-
dc.identifier.pmid32139696-
dc.identifier.pmcidPMC7057957-
dc.identifier.scopuseid_2-s2.0-85081226881-
dc.identifier.hkuros309909-
dc.identifier.volume11-
dc.identifier.spagearticle no. 1217-
dc.identifier.epagearticle no. 1217-
dc.publisher.placeUnited Kingdom-

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