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Conference Paper: Impact of silica nanoparticles-induced neurodegeneration and cognitive impairment, an example on the effect of environmental pollutant

TitleImpact of silica nanoparticles-induced neurodegeneration and cognitive impairment, an example on the effect of environmental pollutant
Authors
Issue Date2018
PublisherSociety for Neuroscience. The Journal's web site is located at https://www.sfn.org/annual-meeting/past-and-future-annual-meetings
Citation
Society for Neuroscience 2018 Annual Meeting, San Diego, USA, 3-7 November 2018. In Neuroscience 2018 Abstracts How to Cite?
AbstractSilica nanoparticles(SiO2-NPs) are one of the most broadly exploited nanomaterials and have been utilized in a variety of industries. They are also the most common component in a number of airborne pollutants, including mineral dust and particulate matter (PM),found in ambient air as well as circulated air in households and workplaces. Air pollution has been considered to be a risk factor for inducing Alzheimer’s disease (AD). After inhalation, SiO2-NPs penetrate the epithelium of the respiratory tract and are then translocated to the brain via either the circulatory system or the olfactory nerve. However, the role of SiO2-NPs in neurodegeneration is largely unknown. Here, we evaluated the effects of SiO2-NPs-exposure on behavior, neuropathology, and synapse in young adult mice and primary cortical neuron cultures. Male C57BL/6N mice (3 months old) were exposed to either vehicle (sterile PBS) or fluorescein isothiocyanate-tagged SiO2-NPs (NP) using intranasal instillation. Behavioral tests were performed after 1 and 2 months of exposure. We observed decreased social activity at both time points as well as anxiety and cognitive impairment after 2 months in the NP-exposed mice. NP deposition was primarily detected in the medial prefrontal cortex and the hippocampus. Neurodegeneration-like pathological changes, including reduced Nissl bodies, increased tau phosphorylation, and neuroinflammation, were also present in the brains of NP-exposed mice. Furthermore, we observed NP-induced impairment in exocytosis along with decreased synapsin I and increased synaptophysin expression in the synaptosome fractions isolated from the frontal cortex as well as primary neuronal cultures. Extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) were also activated in the frontal cortex of NP-exposed mice. Moreover, inhibition of ERK activation prevented NP-mediated changes in exocytosis in cultured neurons, highlighting a key role in the changes induced by NP exposure. In conclusion, intranasal instillation of SiO2-NPs results in mood dysfunction and cognitive impairment in young adult mice and causes neurodegeneration-like pathology and synaptic changes via ERK activation. The results may explain why air pollution can be a risk factor for developing AD.
DescriptionSession 188 - Alzheimer's Disease and Other Dementias: Tau and TDP-43 Proteinopathies - no. 188.08
Persistent Identifierhttp://hdl.handle.net/10722/282371
ISSN

 

DC FieldValueLanguage
dc.contributor.authorChang, RCC-
dc.contributor.authorYou, R-
dc.contributor.authorLiu, Y-
dc.contributor.authorHuang, C-
dc.contributor.authorLi, HW-
dc.contributor.authorHo, YS-
dc.date.accessioned2020-05-11T06:21:47Z-
dc.date.available2020-05-11T06:21:47Z-
dc.date.issued2018-
dc.identifier.citationSociety for Neuroscience 2018 Annual Meeting, San Diego, USA, 3-7 November 2018. In Neuroscience 2018 Abstracts-
dc.identifier.issn0190-5295-
dc.identifier.urihttp://hdl.handle.net/10722/282371-
dc.descriptionSession 188 - Alzheimer's Disease and Other Dementias: Tau and TDP-43 Proteinopathies - no. 188.08-
dc.description.abstractSilica nanoparticles(SiO2-NPs) are one of the most broadly exploited nanomaterials and have been utilized in a variety of industries. They are also the most common component in a number of airborne pollutants, including mineral dust and particulate matter (PM),found in ambient air as well as circulated air in households and workplaces. Air pollution has been considered to be a risk factor for inducing Alzheimer’s disease (AD). After inhalation, SiO2-NPs penetrate the epithelium of the respiratory tract and are then translocated to the brain via either the circulatory system or the olfactory nerve. However, the role of SiO2-NPs in neurodegeneration is largely unknown. Here, we evaluated the effects of SiO2-NPs-exposure on behavior, neuropathology, and synapse in young adult mice and primary cortical neuron cultures. Male C57BL/6N mice (3 months old) were exposed to either vehicle (sterile PBS) or fluorescein isothiocyanate-tagged SiO2-NPs (NP) using intranasal instillation. Behavioral tests were performed after 1 and 2 months of exposure. We observed decreased social activity at both time points as well as anxiety and cognitive impairment after 2 months in the NP-exposed mice. NP deposition was primarily detected in the medial prefrontal cortex and the hippocampus. Neurodegeneration-like pathological changes, including reduced Nissl bodies, increased tau phosphorylation, and neuroinflammation, were also present in the brains of NP-exposed mice. Furthermore, we observed NP-induced impairment in exocytosis along with decreased synapsin I and increased synaptophysin expression in the synaptosome fractions isolated from the frontal cortex as well as primary neuronal cultures. Extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) were also activated in the frontal cortex of NP-exposed mice. Moreover, inhibition of ERK activation prevented NP-mediated changes in exocytosis in cultured neurons, highlighting a key role in the changes induced by NP exposure. In conclusion, intranasal instillation of SiO2-NPs results in mood dysfunction and cognitive impairment in young adult mice and causes neurodegeneration-like pathology and synaptic changes via ERK activation. The results may explain why air pollution can be a risk factor for developing AD.-
dc.languageeng-
dc.publisherSociety for Neuroscience. The Journal's web site is located at https://www.sfn.org/annual-meeting/past-and-future-annual-meetings-
dc.relation.ispartofSociety for Neuroscience Abstracts-
dc.rightsSociety for Neuroscience Abstracts. Copyright © Society for Neuroscience.-
dc.titleImpact of silica nanoparticles-induced neurodegeneration and cognitive impairment, an example on the effect of environmental pollutant-
dc.typeConference_Paper-
dc.identifier.emailChang, RCC: rccchang@hku.hk-
dc.identifier.authorityChang, RCC=rp00470-
dc.identifier.hkuros304037-
dc.publisher.placeUnited States-
dc.identifier.issnl0190-5295-

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