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Article: The Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases

TitleThe Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases
Authors
Keywordslung diseases
allergy
asthma
chronic obstructive pulmonary disease
cystic fibrosis
Issue Date2020
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/microbiology/
Citation
Frontiers in Microbiology, 2020, v. 11, p. article no. 301 How to Cite?
AbstractEmerging findings indicate there is a vital cross-talk between gut microbiota and the lungs, which is known as gut–lung axis. The gut disturbances in lung diseases including allergy, asthma, chronic obstructive pulmonary disease, cystic fibrosis and lung cancer were observed by extensive studies. Investigating how gut microbiota impact other distant organs is of great interest in recent years. Although it has not been fully understood whether the disturbance is the cause or effect of lung diseases, alterations in the gut microbial species and metabolites have been linked to changes in immune responses and inflammation as well as the disease development in the lungs. In this article, we systemically review the role and mechanisms underlying the changes in the constituent of gut microbiota and metabolites in lung diseases. In particular, the roles of gut–lung axis in mediating immune responses and reshaping inflammation are highlighted. Furthermore, we discuss the potential of strategies to manipulate the gut microbiota and metabolites as the therapeutic approach for lung diseases.
Persistent Identifierhttp://hdl.handle.net/10722/282256
ISSN
2023 Impact Factor: 4.0
2023 SCImago Journal Rankings: 1.065
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, D-
dc.contributor.authorLi, S-
dc.contributor.authorWang, N-
dc.contributor.authorTan, H-Y-
dc.contributor.authorZhang, Z-
dc.contributor.authorFeng, Y-
dc.date.accessioned2020-05-05T14:32:47Z-
dc.date.available2020-05-05T14:32:47Z-
dc.date.issued2020-
dc.identifier.citationFrontiers in Microbiology, 2020, v. 11, p. article no. 301-
dc.identifier.issn1664-302X-
dc.identifier.urihttp://hdl.handle.net/10722/282256-
dc.description.abstractEmerging findings indicate there is a vital cross-talk between gut microbiota and the lungs, which is known as gut–lung axis. The gut disturbances in lung diseases including allergy, asthma, chronic obstructive pulmonary disease, cystic fibrosis and lung cancer were observed by extensive studies. Investigating how gut microbiota impact other distant organs is of great interest in recent years. Although it has not been fully understood whether the disturbance is the cause or effect of lung diseases, alterations in the gut microbial species and metabolites have been linked to changes in immune responses and inflammation as well as the disease development in the lungs. In this article, we systemically review the role and mechanisms underlying the changes in the constituent of gut microbiota and metabolites in lung diseases. In particular, the roles of gut–lung axis in mediating immune responses and reshaping inflammation are highlighted. Furthermore, we discuss the potential of strategies to manipulate the gut microbiota and metabolites as the therapeutic approach for lung diseases.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/microbiology/-
dc.relation.ispartofFrontiers in Microbiology-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectlung diseases-
dc.subjectallergy-
dc.subjectasthma-
dc.subjectchronic obstructive pulmonary disease-
dc.subjectcystic fibrosis-
dc.titleThe Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases-
dc.typeArticle-
dc.identifier.emailZhang, D: zpeng@hku.hk-
dc.identifier.emailLi, S: lishaha@hku.hk-
dc.identifier.emailWang, N: ckwang@hku.hk-
dc.identifier.emailTan, H-Y: hyhtan@hku.hk-
dc.identifier.emailFeng, Y: yfeng@hku.hk-
dc.identifier.authorityWang, N=rp02075-
dc.identifier.authorityFeng, Y=rp00466-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fmicb.2020.00301-
dc.identifier.scopuseid_2-s2.0-85082006063-
dc.identifier.hkuros309775-
dc.identifier.volume11-
dc.identifier.spagearticle no. 301-
dc.identifier.epagearticle no. 301-
dc.identifier.isiWOS:000526664200001-
dc.publisher.placeSwitzerland-
dc.identifier.issnl1664-302X-

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