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Article: The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism
Title | The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism |
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Authors | |
Keywords | herbal medicines natural products lipid metabolism fatty liver lipolysis |
Issue Date | 2020 |
Publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/pharmacology |
Citation | Frontiers in Pharmacology, 2020, v. 11, p. article no. 351 How to Cite? |
Abstract | The dysregulation of hepatic lipid metabolism is one of the hallmarks in many liver diseases including alcoholic liver diseases (ALD) and non-alcoholic fatty liver diseases (NAFLD). Hepatic inflammation, lipoperoxidative stress as well as the imbalance between lipid availability and lipid disposal, are direct causes of liver steatosis. The application of herbal medicines with anti-oxidative stress and lipid-balancing properties has been extensively attempted as pharmaceutical intervention for liver disorders in experimental and clinical studies. Although the molecular mechanisms underlying their hepatoprotective effects warrant further exploration, increasing evidence demonstrated that many herbal medicines are involved in regulating lipid accumulation processes including hepatic lipolytic and lipogenic pathways, such as mitochondrial and peroxisomal β-oxidation, the secretion of very low density lipoprotein (VLDL), the non-esterified fatty acid (NEFA) uptake, and some vital hepatic lipogenic enzymes. Therefore, in this review, the pathways or crucial mediators participated in the dysregulation of hepatic lipid metabolism are systematically summarized, followed by the current evidences and advances in the positive impacts of herbal medicines and natural products on the lipid metabolism pathways are detailed. Furthermore, several herbal formulas, herbs or herbal derivatives, such as Erchen Dection, Danshen, resveratrol, and berberine, which have been extensively studied for their promising potential in mediating lipid metabolism, are particularly highlighted in this review. |
Persistent Identifier | http://hdl.handle.net/10722/282253 |
ISSN | 2021 Impact Factor: 5.988 2020 SCImago Journal Rankings: 1.384 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, S | - |
dc.contributor.author | XU, Y | - |
dc.contributor.author | GUO, W | - |
dc.contributor.author | CHEN, F | - |
dc.contributor.author | ZHANG, C | - |
dc.contributor.author | Tan, HY | - |
dc.contributor.author | Wang, N | - |
dc.contributor.author | Feng, Y | - |
dc.date.accessioned | 2020-05-05T14:32:45Z | - |
dc.date.available | 2020-05-05T14:32:45Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Frontiers in Pharmacology, 2020, v. 11, p. article no. 351 | - |
dc.identifier.issn | 1663-9812 | - |
dc.identifier.uri | http://hdl.handle.net/10722/282253 | - |
dc.description.abstract | The dysregulation of hepatic lipid metabolism is one of the hallmarks in many liver diseases including alcoholic liver diseases (ALD) and non-alcoholic fatty liver diseases (NAFLD). Hepatic inflammation, lipoperoxidative stress as well as the imbalance between lipid availability and lipid disposal, are direct causes of liver steatosis. The application of herbal medicines with anti-oxidative stress and lipid-balancing properties has been extensively attempted as pharmaceutical intervention for liver disorders in experimental and clinical studies. Although the molecular mechanisms underlying their hepatoprotective effects warrant further exploration, increasing evidence demonstrated that many herbal medicines are involved in regulating lipid accumulation processes including hepatic lipolytic and lipogenic pathways, such as mitochondrial and peroxisomal β-oxidation, the secretion of very low density lipoprotein (VLDL), the non-esterified fatty acid (NEFA) uptake, and some vital hepatic lipogenic enzymes. Therefore, in this review, the pathways or crucial mediators participated in the dysregulation of hepatic lipid metabolism are systematically summarized, followed by the current evidences and advances in the positive impacts of herbal medicines and natural products on the lipid metabolism pathways are detailed. Furthermore, several herbal formulas, herbs or herbal derivatives, such as Erchen Dection, Danshen, resveratrol, and berberine, which have been extensively studied for their promising potential in mediating lipid metabolism, are particularly highlighted in this review. | - |
dc.language | eng | - |
dc.publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/pharmacology | - |
dc.relation.ispartof | Frontiers in Pharmacology | - |
dc.rights | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | herbal medicines | - |
dc.subject | natural products | - |
dc.subject | lipid metabolism | - |
dc.subject | fatty liver | - |
dc.subject | lipolysis | - |
dc.title | The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism | - |
dc.type | Article | - |
dc.identifier.email | Li, S: lishaha@hku.hk | - |
dc.identifier.email | Tan, HY: hyhtan@hku.hk | - |
dc.identifier.email | Wang, N: ckwang@hku.hk | - |
dc.identifier.email | Feng, Y: yfeng@hku.hk | - |
dc.identifier.authority | Wang, N=rp02075 | - |
dc.identifier.authority | Feng, Y=rp00466 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3389/fphar.2020.00351 | - |
dc.identifier.scopus | eid_2-s2.0-85083093093 | - |
dc.identifier.hkuros | 309770 | - |
dc.identifier.volume | 11 | - |
dc.identifier.spage | article no. 351 | - |
dc.identifier.epage | article no. 351 | - |
dc.identifier.isi | WOS:000596907000001 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 1663-9812 | - |